5 Conclusions
Separate theories of growth and remodeling have been outlined to illustrate that remodeling may occur at constant mass and is a configurational change whereas growth involves a change in the concentration of species. Engineered tendon constructs were generated for growth and remodeling studies. The constructs demonstrate mechanically responsive cells, grow and remain viable in culture for several weeks. They are excellent in vitro models for growth studies.
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References
Andrick, J. J., Mundy, K., Calve, S. C., Arruda, E. M., and Baar, K. (2005). Uniaxial stretch results in increased collagen in fibrin-based 3D engineered tendon. J. Appl. Physiol. submitted.
Arruda, E. M., Mundy, K., Calve, S. C., and Baar, K. (2005). Denervation decreases tendon extensibility and increases tendon stiffness. J. Physiol. submitted.
Bischoff, J. E., Arruda, E. M., and Grosh, K. (2002a). A microstructurally based orthotropic hyperelastic constitutive law. J. Appl. Mech. 69:570–579.
Bischoff, J. E., Arruda, E. M., and Grosh, K. (2002b). Orthotropic hyperelasticity in terms of an arbitrary molecular chain model. Tissue Eng. 10:755–761.
Calve, S. C., Dennis, R. G., Kosnik II, P. E., Baar, K., and Arruda, E. M. (2004). Engineering of functional tendon. J. Appl. Mech. 69:199–201.
Epstein, M., and Maugin, G. A. (2000). Thermomechanics of volumetric growth in uniform bodies. Int. J. Plasticity 16:951–978.
Garikipati, K., Arruda, E. M., Grosh, K., Narayanan, H., and Calve, S. C. (2004). A continuum treatment of growth in biological tissue: The coupling of mass transport and mechanics. J. Mech. Phys. Solids 52:1595–1625.
Garikipati, K., Narayanan, H., Arruda, E. M., Grosh, K., and Calve, S. C. (2005). Material forces in the context of biotissue remodelling. In Steinmann, P., and Maugin, G. A., eds., Mechanics of Material Forces. Dordrecht: Kluwer Academic Publishers. E-print available at http://arXiv.org/abs/q-bio.QM/0312002.
Humphrey, J. D., and Rajagopal, K. R. (2002). A constrained mixture model for growth and remodeling of soft tissues. Math. Model. Meth. Appl. Sci. 12:407–430.
Klisch, S. M., Van Dyke, T. J., and Hoger, A. (2001). A theory of volumetric growth for compressible elastic biological materials. Math. Mech. Solids 6:551–575.
Kuhl, E., and Steinmann, P. (2002). Geometrically nonlinear functional adaptation of biological microstructures. In Mang, H. A., Rammerstorfer, F. G., and Eberhardsteiner, J., eds., Proceedings of the Fifth World Congress on Computational Mechanics (WCCM V), 1–21. Vienna, Austria: International Association for Computational Mechanics.
Nordin, M., Lorenz, T., and Campello, M. (2001). Biomechanics of tendons and ligaments. In Nordin, M., and Frankel, V. H., eds., Basic Biomechanics of the Musculoskeletal System. New York: Lippincott Williams and Wilkins. 102–125.
Sengers, B. G., Oomens, C. W. J., and Baaijens, F. P. T. (2004). An integrated finite-element approach to mechanics, transport and biosynthesis in tissue engineering. J. Biomech. Eng. 126:82–91.
Taber, L. A., and Humphrey, J. D. (2001). Stress-modulated growth, residual stress, and vascular heterogeneity. J. Biomech. Eng. 123:528–535.
Woessner, J. F. (1961). The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. Arch. Biochem. Biophys. 93:440–447.
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Arruda, E.M., Calve, S.C., Garikipati, K., Grosh, K., Narayanan, H. (2006). Characterization and Modeling of Growth and Remodeling in Tendon and Soft Tissue Constructs. In: Holzapfel, G.A., Ogden, R.W. (eds) Mechanics of Biological Tissue. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-31184-X_5
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DOI: https://doi.org/10.1007/3-540-31184-X_5
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