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Tissue Microarrays for Miniaturized High-Throughput Molecular Profiling of Tumors

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Book cover Microarray Technology and Its Applications

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

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References

  1. Schweitzer, B. and Kingsmore, S. F. Measuring proteins on microarrays. Curr Opin Biotechnol, 13: 14–19, 2002

    Article  PubMed  CAS  Google Scholar 

  2. Belin, D. The use of RNA probes for the analysis of gene expression. Northern blot hybridization and ribonuclease protection assay. Methods Mol Biol, 86: 87–102, 1998

    PubMed  CAS  Google Scholar 

  3. Bichsel, V. E., Liotta, L. A., and Petricoin, E. F., 3rd Cancer proteomics: from biomarker discovery to signal pathway profiling. Cancer J, 7: 69–78, 2001

    PubMed  CAS  Google Scholar 

  4. Kallioniemi, O. P. Biochip technologies in cancer research. Ann Med, 33: 142–147, 2001

    PubMed  CAS  Google Scholar 

  5. Walker, N. J. Real-time and quantitative PCR: applications to mechanism-based toxicology. J Biochem Mol Toxicol, 15: 121–127, 2001

    Article  PubMed  CAS  Google Scholar 

  6. Kononen, J., Bubendorf, L., Kallioniemi, A., Bärlund, M., Schraml, P., Leighton, S., Torhorst, J., Mihatsch, M., Sauter, G., and Kallioniemi, O. Tissue microarrays for high-throughput molecular profiling of hundreds of specimens. Nat Med, 4: 844–847, 1998

    Article  PubMed  CAS  Google Scholar 

  7. Camp, R. L., Charette, L. A., and Rimm, D. L. Validation of tissue microarray technology in breast carcinoma. Lab Invest, 80: 1943–1949, 2000

    Article  PubMed  CAS  Google Scholar 

  8. Gancberg, D., Di Leo, A., Rouas, G., Jarvinen, T., Verhest, A., Isola, J., Piccart, M. J., and Larsimont, D. Reliability of the tissue microarray based FISH for evaluation of the HER-2 oncogene in breast carcinoma. J Clin Pathol, 55: 315–317, 2002

    Article  PubMed  CAS  Google Scholar 

  9. Hoos, A., Urist, M. J., Stojadinovic, A., Mastorides, S., Dudas, M. E., Leung, D. H., Kuo, D., Brennan, M. F., Lewis, J. J., and Cordon-Cardo, C. Validation of tissue microarrays for immunohistochemical profiling of cancer specimens using the example of human fibroblastic tumors. Am J Pathol, 158: 1245–1251, 2001

    PubMed  CAS  Google Scholar 

  10. Nocito, A., Bubendorf, L., Maria Tinner, E., Suess, K., Wagner, U., Forster, T., Kononen, J., Fijan, A., Bruderer, J., Schmid, U., Ackermann, D., Maurer, R., Alund, G., Knonagel, H., Rist, M., Anabitarte, M., Hering, F., Hardmeier, T., Schoenenberger, A. J., Flury, R., Jager, P., Luc Fehr, J., Schraml, P., Moch, H., Mihatsch, M. J., Gasser, T., and Sauter, G. Microarrays of bladder cancer tissue are highly representative of proliferation index and histological grade. J Pathol, 194: 349–357, 2001

    Article  PubMed  CAS  Google Scholar 

  11. Rimm, D. L., Camp, R. L., Charette, L. A., Costa, J., Olsen, D. A., and Reiss, M. Tissue microarray: a new technology for amplification of tissue resources. Cancer J, 7: 24–31, 2001

    PubMed  CAS  Google Scholar 

  12. Engellau, J., Akerman, M., Anderson, H., Domanski, H. A., Rambech, E., Alvegard, T. A., and Nilbert, M. Tissue microarray technique in soft tissue sarcoma: immunohisto-chemical Ki-67 expression in malignant fibrous histiocytoma. Appl Immunohistochem Mol Morphol, 9: 358–363, 2001

    Article  PubMed  CAS  Google Scholar 

  13. Fernebro, E., Dictor, M., Bendahl, P. O., Ferno, M., and Nilbert, M. Evaluation of the tissue microarray technique for immunohistochemical analysis in rectal cancer. Arch Pathol Lab Med, 126: 702–705, 2002

    PubMed  Google Scholar 

  14. Garcia, J. F., Camacho, F. I., Morente, M., Fraga, M., Montalban, C., Alavaro, T., Bellas, C., Castano, A., Diez, A., Flores, T., Martin, C., Martinez, M. A., Mazorra, F., Menarguez, J., Mestre, M. J., Mollejo, M., Saez, A. I., Sanchez, L., and Piris, M. A. Hodgkin's and Reed-Sternberg cells harbor alterations in the major tumor suppressor pathways and cell-cycle checkpoints: analyses using tissue-microarrays. Blood, 12: 12, 2002

    Google Scholar 

  15. Ginestier, C., Charafe-Jauffret, E., Bertucci, F., Eisinger, F., Geneix, J., Bechlian, D., Conte, N., Adelaide, J., Toiron, Y., Nguyen, C., Viens, P., Mozziconacci, M. J., Houlgatte, R., Birnbaum, D., and Jacquemier, J. Distinct and complementary information provided by use of tissue and DNA microarrays in the study of breast tumor markers. Am J Pathol, 161: 1223–1233, 2002

    PubMed  CAS  Google Scholar 

  16. Gulmann, C., Butler, D., Kay, E., Grace, A., and Leader, M. Biopsy of a biopsy: validation of immunoprofiling in gastric cancer biopsy tissue microarrays. Histopathology, 42: 70–76, 2003

    Article  PubMed  CAS  Google Scholar 

  17. Hedvat, C. V., Hegde, A., Chaganti, R. S., Chen, B., Qin, J., Filippa, D. A., Nimer, S. D., and Teruya-Feldstein, J. Application of tissue microarray technology to the study of non-Hodgkin's and Hodgkin's lymphoma. Hum Pathol, 33:968–974, 2002

    Article  PubMed  Google Scholar 

  18. Hendriks, Y., Franken, P., Dierssen, J. W., De Leeuw, W., Wijnen, J., Dreef, E., Tops, C., Breuning, M., Brocker-Vriends, A., Vasen, H., Fodde, R., and Morreau, H. Conventional and tissue microarray immunohistochemical expression analysis of mismatch repair in hereditary colorectal tumors. Am J Pathol, 162: 469–477, 2003

    PubMed  CAS  Google Scholar 

  19. Merseburger, A. S., Kuczyk, M. A., Serth, J., Bokemeyer, C., Young, D. Y., Sun, L., Connelly, R. R., McLeod, D. G., Mostofi, F. K., Srivastava, S. K., Stenzl, A., Moul, J. W., and Sesterhenn, I. A. Limitations of tissue microarrays in the evaluation of focal alterations of bcl-2 and p53 in whole mount derived prostate tissues. Oncol Rep, 10: 223–228, 2003

    PubMed  CAS  Google Scholar 

  20. Moch, H., Schraml, P., Bubendorf, L., Mirlacher, M., Kononen, J., Gasser, T., Mihatsch, M. J., Kallioniemi, O. P., and Sauter, G. High-throughput tissue microarray analysis to evaluate genes uncovered by cDNA microarray screening in renal cell carcinoma. Am J Pathol, 154: 981–986, 1999

    PubMed  CAS  Google Scholar 

  21. Mucci, N. R., Akdas, G., Manely, S., and Rubin, M. A. Neuroendocrine expression in metastatic prostate cancer: evaluation of high throughput tissue microarrays to detect heterogeneous protein expression. Hum Pathol, 31: 406–414, 2000

    Article  PubMed  CAS  Google Scholar 

  22. Natkunam, Y., Warnke, R. A., Montgomery, K., Falini, B., and van De Rijn, M. Analysis of mum1/irf4 protein expression using tissue microarrays and immunohistochemistry. Mod Pathol, 14: 686–694, 2001

    Article  PubMed  CAS  Google Scholar 

  23. Rassidakis, G. Z., Jones, D., Thomaides, A., Sen, F., Lai, R., Cabanillas, F., McDonnell, T. J., and Medeiros, L. J. Apoptotic rate in peripheral T-cell lymphomas. A study using a tissue microarray with validation on full tissue sections. Am J Clin Pathol, 118: 328–334, 2002

    Article  PubMed  Google Scholar 

  24. Rubin, M. A., Dunn, R., Strawderman, M., and Pienta, K. J. Tissue microarray sampling strategy for prostate cancer bio-marker analysis. Am J Surg Pathol, 26: 312–319, 2002

    Article  PubMed  Google Scholar 

  25. Sallinen, S. L., Sallinen, P. K., Haapasalo, H. K., Helin, H. J., Helen, P. T., Schraml, P., Kallioniemi, O. P., and Kononen, J. Identification of di erentially expressed genes in human gliomas by DNA microarray and tissue chip techniques. Cancer Res, 60: 6617–6622, 2000

    PubMed  CAS  Google Scholar 

  26. Torhorst, J., Bucher, C., Kononen, J., Haas, P., Zuber, M., Kochli, O. R., Mross, F., Dieterich, H., Moch, H., Mihatsch, M., Kallioniemi, O. P., and Sauter, G. Tissue microarrays for rapid linking of molecular changes to clinical endpoints. Am J Pathol, 159: 2249–2256, 2001

    PubMed  CAS  Google Scholar 

  27. Tzankov, A., Zimpfer, A., Lugli, A., Krugmann, J., Went, P., Schraml, P., Maurer, R., Ascani, S., Pileri, S., Geley, S., and Dirnhofer, S. High-throughput tissue microarray analysis of G1-cyclin alterations in classical Hodgkin's lymphoma indicates overexpression of cyclin E1. J Pathol, 199: 201–207, 2003

    Article  PubMed  CAS  Google Scholar 

  28. Yosepovich, A. and Kopolovic, J. Tissue microarray technology-a new and powerful tool for the molecular profiling of tumors. Harefuah, 141: 1039–1041, 1090, 2002

    PubMed  Google Scholar 

  29. Hoos, A., Stojadinovic, A., Mastorides, S., Urist, M. J., Polsky, D., Di Como, C. J., Brennan, M. F., and Cordon-Cardo, C. High Ki-67 proliferative index predicts disease specific survival in patients with high-risk soft tissue sarcomas. Cancer, 92: 869–874, 2001

    Article  PubMed  CAS  Google Scholar 

  30. Hoos, A., Stojadinovic, A., Singh, B., Dudas, M. E., Leung, D. H., Shaha, A. R., Shah, J. P., Brennan, M. F., Cordon-Cardo, C., and Ghossein, R. Clinical significance of molecular expression profiles of Hurthle cell tumors of the thyroid gland analyzed via tissue microarrays. Am J Pathol, 160: 175–183, 2002

    PubMed  CAS  Google Scholar 

  31. Barlund, M., Forozan, F., Kononen, J., Bubendorf, L., Chen, Y., Bittner, M. L., Torhorst, J., Haas, P., Bucher, C., Sauter, G., Kallioniemi, O. P., and Kallioniemi, A. Detecting activation of ribosomal protein S6 kinase by complementary DNA and tissue microarray analysis. J Natl Cancer Inst, 92: 1252–1259, 2000

    Article  PubMed  CAS  Google Scholar 

  32. Schraml, P., Kononen, J., Bubendorf, L., Moch, H., Bissig, H., Nocito, A., Mihatsch, M., Kallioniemi, O., and Sauter, G. Tissue microarrays for gene amplification surveys in many di erent tumor types. Clin Cancer Res, 5: 1966–1975, 1999

    PubMed  CAS  Google Scholar 

  33. Richter, J., Wagner, U., Kononen, J., Fijan, A., Bruderer, J., Schmid, U., Ackermann, D., Maurer, R., Alund, G., Knonagel, H., Rist, M., Wilber, K., Anabitarte, M., Hering, F., Hardmeier, T., Schonenberger, A., Flury, R., Jager, P., Fehr, J. L., Schraml, P., Moch, H., Mihatsch, M. J., Gasser, T., Kallioniemi, O. P., and Sauter, G. High-throughput tissue microarray analysis of cyclin E gene amplification and over-expression in urinary bladder cancer. Am J Pathol, 157: 787–794, 2000

    PubMed  CAS  Google Scholar 

  34. Simon, R., Richter, J., Wagner, U., Fijan, A., Bruderer, J., Schmid, U., Ackermann, D., Maurer, R., Alund, G., Knonagel, H., Rist, M., Wilber, K., Anabitarte, M., Hering, F., Hardmeier, T., Schonenberger, A., Flury, R., Jager, P., Fehr, J. L., Schraml, P., Moch, H., Mihatsch, M. J., Gasser, T., and Sauter, G. High-throughput tissue microarray analysis of 3p25 (RAF1) and 8p12 (FGFR1) copy number alterations in urinary bladder cancer. Cancer Res, 61: 4514–4519, 2001

    PubMed  CAS  Google Scholar 

  35. Simon, R., Struckmann, K., Schraml, P., Wagner, U., Forster, T., Moch, H., Fijan, A., Bruderer, J., Wilber, K., Mihatsch, M. J., Gasser, T., and Sauter, G. Amplification pattern of 12q13–q15 genes (MDM2, CDK4, GLI) in urinary bladder cancer. Oncogene, 21: 2476–2483, 2002

    Article  PubMed  CAS  Google Scholar 

  36. Kocher, T., Zheng, M., Bolli, M., Simon, R., Forster, T., Schultz-Thater, E., Remmel, E., Noppen, C., Schmid, U., Ackermann, D., Mihatsch, M. J., Gasser, T., Heberer, M., Sauter, G., and Spagnoli, G. C. Prognostic relevance of MAGE-A4 tumor antigen expression in transitional cell carcinoma of the urinary bladder: a tissue microarray study. Int J Cancer, 100: 702–705, 2002

    Article  PubMed  CAS  Google Scholar 

  37. Park, S. Y., Kim, H. S., Hong, E. K., and Kim, W. H. Expression of cytokeratins 7 and 20 in primary carcinomas of the stomach and colorectum and their value in the di erential diagnosis of metastatic carcinomas to the ovary. Hum Pathol, 33: 1078–1085, 2002

    Article  PubMed  CAS  Google Scholar 

  38. Bubendorf, L., Kolmer, M., Kononen, J., Koivisto, P., Mousses, S., Chen, Y., Mahlamaki, E., Schraml, P., Moch, H., Willi, N., Elkahloun, A. G., Pretlow, T. G., Gasser, T. C., Mihatsch, M. J., Sauter, G., and Kallioniemi, O. P. Hormone therapy failure in human prostate cancer: analysis by complementary DNA and tissue microarrays. J Natl Cancer Inst, 91: 1758–1764, 1999

    Article  PubMed  CAS  Google Scholar 

  39. Saramaki, O., Willi, N., Bratt, O., Gasser, T. C., Koivisto, P., Nupponen, N. N., Bubendorf, L., and Visakorpi, T. Amplification of EIF3S3 gene is associated with advanced stage in prostate cancer. Am J Pathol, 159: 2089–2094, 2001

    PubMed  CAS  Google Scholar 

  40. Skacel, M., Ormsby, A. H., Pettay, J. D., Tsiftsakis, E. K., Liou, L. S., Klein, E. A., Levin, H. S., Zippe, C. D., and Tubbs, R. R. Aneusomy of chromosomes 7, 8, and 17 and amplification of HER-2/neu and epidermal growth factor receptor in Gleason score 7 prostate carcinoma: a differential fluorescent in situ hybridization study of Gleason pattern 3 and 4 using tissue microarray. Hum Pathol, 32: 1392–1397, 2001

    Article  PubMed  CAS  Google Scholar 

  41. Rubin, M. A., Mucci, N. R., Figurski, J., Fecko, A., Pienta, K. J., and Day, M. L. E-cadherin expression in prostate cancer: a broad survey using high-density tissue microarray technology. Hum Pathol, 32: 690–697, 2001

    Article  PubMed  CAS  Google Scholar 

  42. Fuller, C. E., Wang, H., Zhang, W., Fuller, G. N., and Perry, A. High-throughput molecular profiling of high-grade astro-cytomas: the utility of fluorescence in situ hybridization on tissue microarrays (TMA-FISH). J Neuropathol Exp Neurol, 61: 1078–1084, 2002

    PubMed  CAS  Google Scholar 

  43. Korsching, E., Packeisen, J., Agelopoulos, K., Eisenacher, M., Voss, R., Isola, J., van Diest, P. J., Brandt, B., Boecker, W., and Buerger, H. Cytogenetic alterations and cytokeratin expression patterns in breast cancer: integrating a new model of breast di erentiation into cytogenetic pathways of breast carcinogenesis. Lab Invest, 82: 1525–1533, 2002

    PubMed  CAS  Google Scholar 

  44. Allander, S. V., Illei, P. B., Chen, Y., Antonescu, C. R., Bittner, M., Ladanyi, M., and Meltzer, P. S. Expression profiling of synovial sarcoma by cDNA microarrays: association of ERBB2, IGFBP2, and ELF3 with epithelial di erentiation. Am J Pathol, 161: 1587–1595, 2002

    PubMed  CAS  Google Scholar 

  45. Oka, T., Yoshino, T., Hayashi, K., Ohara, N., Nakanishi, T., Yamaai, Y., Hiraki, A., Sogawa, C. A., Kondo, E., Teramoto, N., Takahashi, K., Tsuchiyama, J., and Akagi, T. Reduction of hematopoietic cell-specific tyrosine phosphatase SHP-1 gene expression in natural killer cell lymphoma and various types of lymphomas/leukemias: combination analysis with cDNA expression array and tissue microarray. Am J Pathol, 159: 1495–1505, 2001

    PubMed  CAS  Google Scholar 

  46. Monni, O., Barlund, M., Mousses, S., Kononen, J., Sauter, G., Heiskanen, M., Paavola, P., Avela, K., Chen, Y., Bittner, M. L., and Kallioniemi, A. Comprehensive copy number and gene expression profiling of the 17q23 amplicon in human breast cancer. Proc Natl Acad Sci U S A, 98: 5711–5716, 2001

    Article  PubMed  CAS  Google Scholar 

  47. Andersen, C. L., Monni, O., Wagner, U., Kononen, J., Barlund, M., Bucher, C., Haas, P., Nocito, A., Bissig, H., Sauter, G., and Kallioniemi, A. High-throughput copy number analysis of 17q23 in 3520 tissue specimens by fluorescence in situ hybridization to tissue microarrays. Am J Pathol, 161: 73–79, 2002

    PubMed  CAS  Google Scholar 

  48. Bubendorf, L., Kolmer, M., Kononen, J., Koivisto, P., Mousses, S., Chen1, Y., Mahlamäki, E., Schraml, P., Moch, H., Willi, N., Elkahlhoun, A., Pretlow, T., Gasser, T., Mihatsch, M., Sauter, G., and Kallioniemi, O. Molecular mechanisms of hormone therapy failure in human prostate cancer analyzed by a combination of cDNA and tissue microarrays. J Natl Cancer Inst, 91: 1758–1764, 1999

    Article  PubMed  CAS  Google Scholar 

  49. Bubendorf, L., Kononen, J., Koivisto, P., Schraml, P., Moch, H., Gasser, T., Willi, N., Mihatsch, M., Sauter, G., and Kallioniemi, O. Survey of gene amplifications during prostate cancer progression by high-throughput fluorescence in situ hybridization on tissue microarrays. Cancer Res, 59: 803–806, 1999

    PubMed  CAS  Google Scholar 

  50. Richter, J., Wagner, U., Kononen, J., Fijan, A., Bruderer, J., Schmid, U., Ackermann, D., Maurer, R., Alund, G., Knönagel, H., Rist, M., Wilber, K., Anabitarte, M., Hering, F., Hardmeier, T., Schäonenberger, A., Flury, R., Jager, P., Fehr, J. L., Schraml, P., Moch, H., Mihatsch, M. J., Gasser, T., Kallioniemi, O. P., and Sauter, G. High-throughput tissue microarray analysis of cyclin E gene amplification and over-expression in urinary bladder cancer. Am J Pathol, 157: 787–794, 2000

    PubMed  CAS  Google Scholar 

  51. Simon, R., Nocito, A., Hubscher, T., Bucher, C., Torhorst, J., Schraml, P., Bubendorf, L., Mihatsch, M. M., Moch, H., Wilber, K., Schotzau, A., Kononen, J., and Sauter, G. Patterns of her-2/neu amplification and overexpression in primary and metastatic breast cancer. J Natl Cancer Inst, 93: 1141–1146, 2001

    Article  PubMed  CAS  Google Scholar 

  52. Rao, J., Seligson, D., Visapaa, H., Horvath, S., Eeva, M., Michel, K., Pantuck, A., Belldegrun, A., and Palotie, A. Tissue microarray analysis of cytoskeletal actinassociated bio-markers gelsolin and E-cadherin in urothelial carcinoma. Cancer, 95: 1247–1257, 2002

    Article  PubMed  CAS  Google Scholar 

  53. Bucher, C., Torhorst, J., Kononen, J., Haas, P., Askaa, J., Godtfredsen, S. E., Bauer, K. D., Seelig, S., Kallioniemi, O., and Sauter, G. Automated, High-Throughput Tissue Microarray Analysis for Assessing the Significance of HER-2 In-volvement in Breast Cancer. In: Proceedings of the ASCO annual meeting, Abstr. #2388, New Orleans, LA, 2000

    Google Scholar 

  54. Poremba, C., Heine, B., Diallo, R., Heinecke, A., Wai, D., Schaefer, K. L., Braun, Y., Schuck, A., Lanvers, C., Bank-falvi, A., Kneif, S., Torhorst, J., Zuber, M., Kochli, O. R., Mross, F., Dieterich, H., Sauter, G., Stein, H., Fogt, F., and Boecker, W. Telomerase as a prognostic marker in breast cancer: high-throughput tissue microarray analysis of hTERT and hTR. J Pathol, 198: 181–189, 2002

    Article  PubMed  CAS  Google Scholar 

  55. Ristimaki, A., Sivula, A., Lundin, J., Lundin, M., Salminen, T., Haglund, C., Joensuu, H., and Isola, J. Prognostic significance of elevated cyclooxygenase-2 expression in breast cancer. Cancer Res, 62: 632–635, 2002

    PubMed  CAS  Google Scholar 

  56. Bubendorf, L., Kononen, J., Koivisto, P., Schraml, P., Moch, H., Gasser, T. C., Willi, N., Mihatsch, M. J., Sauter, G., and Kallioniemi, O. P. Survey of gene amplifications during prostate cancer progression by high-throughout fluorescence in situ hybridization on tissue microarrays. Cancer Res, 59: 803–806, 1999

    PubMed  CAS  Google Scholar 

  57. Dhanasekaran, S. M., Barrette, T. R., Ghosh, D., Shah, R., Varambally, S., Kurachi, K., Pienta, K. J., Rubin, M. A., and Chinnaiyan, A. M. Delineation of prognostic biomarkers in prostate cancer. Nature, 412: 822–826, 2001

    Article  PubMed  CAS  Google Scholar 

  58. Mousses, S., Bubendorf, L., Wagner, U., Hostetter, G., Kononen, J., Cornelison, R., Goldberger, N., Elkahloun, A. G., Willi, N., Koivisto, P., Ferhle, W., Raffeld, M., Sauter, G., and Kallioniemi, O. P. Clinical validation of candidate genes associated with prostate cancer progression in the CWR22 model system using tissue microarrays. Cancer Res, 62: 1256–1260, 2002

    PubMed  CAS  Google Scholar 

  59. Miettinen, H. E., Jarvinen, T. A., Kellner, U., Kauraniemi, P., Parwaresch, R., Rantala, I., Kalimo, H., Paljarvi, L., Isola, J., and Haapasalo, H. High topoisomerase IIalpha expression associates with high proliferation rate and and poor prognosis in oligodendrogliomas. Neuropathol Appl Neurobiol, 26: 504–512, 2000

    Article  PubMed  CAS  Google Scholar 

  60. Miettinen, H. E., Paunu, N., Rantala, I., Kalimo, H., Paljarvi, L., Helin, H., and Haapasalo, H. Cell cycle regulators (p21, p53, pRb) in oligodendrocytic tumors: a study by novel tumor microarray technique. J Neurooncol, 55: 29–37, 2001

    Article  PubMed  CAS  Google Scholar 

  61. Wang, Y., Wu, M. C., Sham, J. S., Zhang, W., Wu, W. Q., and Guan, X. Y. Prognostic significance of c-myc and AIB1 amplification in hepatocellular carcinoma. A broad survey using high-throughput tissue microarray. Cancer, 95: 2346–2352, 2002

    Article  PubMed  CAS  Google Scholar 

  62. Chung, G. G., Provost, E., Kielhorn, E. P., Charette, L. A., Smith, B. L., and Rimm, D. L. Tissue microarray analysis of beta-catenin in colorectal cancer shows nuclear phospho-beta-catenin is associated with a better prognosis. Clin Cancer Res, 7: 4013–4020, 2001

    PubMed  CAS  Google Scholar 

  63. Hoos, A., Nissan, A., Stojadinovic, A., Shia, J., Hedvat, C. V., Leung, D. H., Paty, P. B., Klimstra, D., Cordon-Cardo, C., and Wong, W. D. Tissue Microarray Molecular Profiling of Early, Node-negative Adenocarcinoma of the Rectum: A Comprehensive Analysis. Clin Cancer Res, 8: 3841–3849, 2002

    PubMed  CAS  Google Scholar 

  64. Otsuka, M., Kato, M., Yoshikawa, T., Chen, H., Brown, E. J., Masuho, Y., Omata, M., and Seki, N. Di erential expression of the L-plastin gene in human colorectal cancer progression and metastasis. Biochem Biophys Res Commun, 289: 876–881, 2001

    Article  PubMed  CAS  Google Scholar 

  65. Kielhorn, E., Provost, E., Olsen, D., D'Aquila, T. G., Smith, B. L., Camp, R. L., and Rimm, D. L. Tissue microarray-based analysis shows phospho-betacatenin expression in malignant melanoma is associated with poor outcome. Int J Cancer, 103: 652–656, 2003

    Article  PubMed  CAS  Google Scholar 

  66. Hoos, A. and Cordon-Cardo, C. Tissue microarray profiling of cancer specimens and cell lines: opportunities and limitations. Lab Invest, 81: 1331–1338, 2001

    PubMed  CAS  Google Scholar 

  67. Mengel, M., von Wasielewski, R., Wiese, B., Rudiger, T., Muller-Hermelink, H. K., and Kreipe, H. Inter-laboratory and inter-observer reproducibility of immunohistochemical assessment of the Ki-67 labelling index in a large multicentre trial. J Pathol, 198: 292–299, 2002

    Article  PubMed  Google Scholar 

  68. von Wasielewski, R., Mengel, M., Wiese, B., Rudiger, T., Muller-Hermelink, H. K., and Kreipe, H. Tissue array technology for testing interlaboratory and interobserver reproducibility of immunohistochemical estrogen receptor analysis in a large multicenter trial. Am J Clin Pathol, 118: 675–682, 2002

    Article  Google Scholar 

  69. Packeisen, J., Buerger, H., Krech, R., and Boecker, W. Tissue microarrays: a new approach for quality control in immunohistochemistry. J Clin Pathol, 55: 613–615, 2002

    Article  PubMed  CAS  Google Scholar 

  70. Manley, S., Mucci, N. R., De Marzo, A. M., and Rubin, M. A. Relational database structure to manage high-density tissue microarray data and images for pathology studies focusing on clinical outcome: the prostate specialized program of research excellence model. Am J Pathol, 159: 837–843, 2001

    PubMed  CAS  Google Scholar 

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  1. Ronald Simon
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  2. Martina Mirlacher
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  1. V.P., Applied Science Nanosphere, Inc., 4088 Commercial Avenue, Northbrook, IL, 60062, USA

    Uwe R. Müller Ph.D.

  2. Swinburne University of Technology, 533-545 Burwood Rd., Hawthorn, Victoria, 3122, Australia

    Dan V. Nicolau

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Simon, R., Mirlacher, M., Sauter, G. (2005). Tissue Microarrays for Miniaturized High-Throughput Molecular Profiling of Tumors. In: Müller, U.R., Nicolau, D.V. (eds) Microarray Technology and Its Applications. Biological and Medical Physics, Biomedical Engineering. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-26578-3_19

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