Skip to main content
SpringerLink
Log in

Benign and Malignant Primary Spinal Tumors

  • Chapter
Stereotactic Body Radiation Therapy

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

  • 2211 Accesses

Abstract

Stereotactic body radiotherapy (SBRT) is increasingly being used in the definitive treatment of patients with primary spine tumors. SBRT-based regimens are used to treat unresectable primary spine tumors and are administered as a neoadjuvant or adjuvant treatment in those receiving definitive surgery. SBRT-based treatments optimize structural, mechanical, and functional outcomes and are emerging as the radiation treatment of choice for several primary tumors of the spine.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Ballo MT, Zagars GK, Cormier JN, Hunt KK, Feig BW, Patel SR, Pisters PW (2004) Interval between surgery and radiotherapy: effect on local control of soft tissue sarcoma. Int J Radiat Oncol Biol Phys 58(5):1461–1467. doi:10.1016/j.ijrobp.2003.09(079), S0360301603020224[pii]

    Google Scholar 

  • Benzil DL, Saboori M, Mogilner AY, Rocchio R, Moorthy CR (2004) Safety and efficacy of stereotactic radiosurgery for tumors of the spine. J Neurosurg 101(3):413–418. doi:10.3171/jns.2004.101.supplement3.0413

    PubMed  Google Scholar 

  • Bilsky MH, Boland PJ, Panageas KS, Woodruff JM, Brennan MF, Healey JH (2001) Intralesional resection of primary and metastatic sarcoma involving the spine: outcome analysis of 59 patients. Neurosurgery 49(6):1286–1287

    Article  Google Scholar 

  • Bilsky MH, Laufer I, Burch S (2009) Shifting paradigms in the treatment of metastatic spine disease. Spine Phila Pa 1976 34(22):S101–S107. doi:10.1097/BRS.0b013e3181bac4b2, 00007632-200910151-00013[pii]

  • Boriani S, Weinstein JN, Biagini R (1997) Primary bone tumors of the spine. Terminology and surgical staging. Spine Phila Pa 1976 22(9):1036–1044

    Article  PubMed  CAS  Google Scholar 

  • Boriani S, De Iure F, Bandiera S, Campanacci L, Biagini R, Di Fiore M, Bandello L, Picci P, Bacchini P (2000) Chondrosarcoma of the mobile spine: report on 22 cases. Spine Phila Pa 1976 25(7):804–812

    Article  PubMed  CAS  Google Scholar 

  • Boriani S, Bandiera S, Biagini R, Bacchini P, Boriani L, Cappuccio M, Chevalley F, Gasbarrini A, Picci P, Weinstein JN (2006) Chordoma of the mobile spine: fifty years of experience. Spine Phila Pa 1976 31(4):493–503. doi:10.1097/01.brs.0000200038.30869.27, 00007632-200602150-00021[pii]

    Google Scholar 

  • Brown JM, Koong AC (2008) High-dose single-fraction radiotherapy: exploiting a new biology? Int J Radiat Oncol Biol Phys 71(2):324–325. S0360-3016(08)00297-6[pii], doi:10.1016/j.ijrobp.2008.02.003

    Google Scholar 

  • Chang DW, Friel MT, Youssef AA (2007) Reconstructive strategies in soft tissue reconstruction after resection of spinal neoplasms. Spine Phila Pa 1976 32(10):1101–1106. doi:10.1097/01.brs.0000261555.72265.3f, 00007632-200705010-00011[pii]

  • Cheng EY, Ozerdemoglu RA, Transfeldt EE, Thompson RC Jr (1999) Lumbosacral chordoma. Prognostic factors and treatment. Spine Phila Pa 1976 24(16):1639–1645

    Article  PubMed  CAS  Google Scholar 

  • Coste-Maniere E, Olender D, Kilby W, Schulz RA (2005) Robotic whole body stereotactic radiosurgery: clinical advantages of the Cyberknife integrated system. Int J Med Robot 1(2):28–39. doi:10.1002/rcs.39

    Article  PubMed  CAS  Google Scholar 

  • Damast S, Wright J, Bilsky M, Hsu M, Zhang Z, Lovelock M, Cox B, Zatcky J, Yamada Y (2011) Impact of dose on local failure rates after image-guided reirradiation of recurrent paraspinal metastases. Int J Radiat Oncol Biol Phys 81(3):819–826. doi:10.1016/j.ijrobp.2010.06.013

    Article  PubMed  Google Scholar 

  • Debus J, Schulz-Ertner D, Schad L, Essig M, Rhein B, Thillmann CO, Wannenmacher M (2000) Stereotactic fractionated radiotherapy for chordomas and chondrosarcomas of the skull base. Int J Radiat Oncol Biol Phys 47(3):591–596. S0360-3016(00)00464-8[pii]

    Google Scholar 

  • Delaney TF, Kepka L, Goldberg SI, Hornicek FJ, Gebhardt MC, Yoon SS, Springfield DS, Raskin KA, Harmon DC, Kirsch DG, Mankin HJ, Rosenberg AE, Nielsen GP, Suit HD (2007) Radiation therapy for control of soft-tissue sarcomas resected with positive margins. Int J Radiat Oncol Biol Phys 67(5):1460–1469. S0360-3016(06)03499-7[pii], doi:10.1016/j.ijrobp.2006.11.035

    Google Scholar 

  • DeLaney TF, Liebsch NJ, Pedlow FX, Adams J, Dean S, Yeap BY, McManus P, Rosenberg AE, Nielsen GP, Harmon DC, Spiro IJ, Raskin KA, Suit HD, Yoon SS, Hornicek FJ (2009) Phase II study of high-dose photon/proton radiotherapy in the management of spine sarcomas. Int J Radiat Oncol Biol Phys 74(3):732–739. S0360-3016(08)03504-9[pii], doi:10.1016/j.ijrobp.2008.08.058

  • Flickinger JC, Kondziolka D, Lunsford LD (2003) Radiobiological analysis of tissue responses following radiosurgery. Technol Cancer Res Treat 2(2):87–92. d=3015&c=4107&p=11646&do=detail[pii]

    Google Scholar 

  • Garcia-Barros M, Paris F, Cordon-Cardo C, Lyden D, Rafii S, Haimovitz-Friedman A, Fuks Z, Kolesnick R (2003) Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science 300(5622):1155–1159. doi:10.1126/science, 1082504300/5622/1155[pii]

    Google Scholar 

  • Gerszten PC, Burton SA, Ozhasoglu C, Welch WC (2007) Radiosurgery for spinal metastases: clinical experience in 500 cases from a single institution. Spine Phila Pa 1976 32(2):193–199. doi:10.1097/01.brs.0000251863.76595.a2, 00007632-200701150-00009[pii]

    Google Scholar 

  • Gerszten PC, Burton SA, Ozhasoglu C, McCue KJ, Quinn AE (2008) Radiosurgery for benign intradural spinal tumors. Neurosurgery 62(4): 887–895 discussion 895–886. doi:10.1227/01.neu.0000318174.28461.fc, 00006123-200804000-00025 [pii]

    Google Scholar 

  • Gibbs IC, Kamnerdsupaphon P, Ryu MR, Dodd R, Kiernan M, Chang SD, Adler JR Jr (2007) Image-guided robotic radiosurgery for spinal metastases. Radiother Oncol 82(2):185–190. S0167-8140(06)00653-0[pii], doi:10.1016/j.radonc.2006.11.023

    Google Scholar 

  • Gibbs IC, Patil C, Gerszten PC, Adler JR Jr, Burton SA (2009) Delayed radiation-induced myelopathy after spinal radiosurgery. Neurosurgery 64(2 suppl):A67–A72. doi:10.1227/01.NEU.0000341628.98141.B6, 00006123-200902001-00011[pii]

    Google Scholar 

  • Guest C, Wang EH, Davis A, Langer F, O’Sullivan B, Noria S, Bell RS (1993) Paraspinal soft-tissue sarcoma. Classification of 14 cases. Spine Phila Pa 1976 18(10):1292–1297

    Article  PubMed  CAS  Google Scholar 

  • Gwak HS, Yoo HJ, Youn SM, Chang U, Lee DH, Yoo SY, Rhee CH (2005) Hypofractionated stereotactic radiation therapy for skull base and upper cervical chordoma and chondrosarcoma: preliminary results. Stereotact Funct Neurosurg 83(5–6):233–243. 91992[pii], doi:10.1159/000091992

    Google Scholar 

  • Imai R, Kamada T, Tsuji H, Yanagi T, Baba M, Miyamoto T, Kato S, Kandatsu S, Mizoe JE, Tsujii H, Tatezaki S (2004) Carbon ion radiotherapy for unresectable sacral chordomas. Clin Cancer Res 10(17):5741–5746. doi:10.1158/1078-0432, CCR-04-030110/17/5741[pii]

    Google Scholar 

  • Kepka L, DeLaney TF, Suit HD, Goldberg SI (2005) Results of radiation therapy for unresected soft-tissue sarcomas. Int J Radiat Oncol Biol Phys 63(3):852–859. S0360-3016(05)00415-3[pii], doi:10.1016/j.ijrobp.2005.03.004

  • Krishnan S, Foote RL, Brown PD, Pollock BE, Link MJ, Garces YI (2005) Radiosurgery for cranial base chordomas and chondrosarcomas. Neurosurgery 56(4):777–784 discussion 777–784

    Article  PubMed  Google Scholar 

  • Levine AM, Coleman C, Horasek S (2009) Stereotactic radiosurgery for the treatment of primary sarcomas and sarcoma metastases of the spine. Neurosurgery 64(2):A54–A59. doi:10.1227/01.NEU.0000339131.28485.4A, 00006123-200902001-00009[pii]

    Google Scholar 

  • Lovelock DM, Hua CH, Wang P, Hunt M, Fournier-Bidoz N, Yenice K, Toner S, Lutz W, Amols H, Bilsky M, Fuks Z, Yamada Y (2005a) Accurate setup of paraspinal patients using a noninvasive patient immobilization cradle and portal imaging. Med Phys 32(8):2606–2614. doi:10.1118/1.1951042

    Article  Google Scholar 

  • Lovelock DM, Hua C, Wang P, Hunt M, Fournier-Bidoz N, Yenice K, Toner S, Lutz W, Amols H, Bilsky M, Fuks Z, Yamada Y (2005b) Accurate setup of paraspinal patients using a noninvasive patient immobilization cradle and portal imaging. Med Phys 32(8):2606–2614

    Article  Google Scholar 

  • Lunsford LD, Niranjan A, Martin JJ, Sirin S, Kassam A, Kondziolka D, Flickinger JC (2007) Radiosurgery for miscellaneous skull base tumors. Prog Neurol Surg 20:192–205. 100114[pii], doi:10.1159/0000100114

    Google Scholar 

  • Martin AG, Cowley IR, Taylor BA, Cassoni AM, Landau DB, Plowman PN (2011) (Stereotactic) radiosurgery XIX: spinal radiosurgery—two year experience in a UK centre. Br J Neurosurg. doi:10.3109/02688697.2011.603857

  • Martin JJ, Niranjan A, Kondziolka D, Flickinger JC, Lozanne KA, Lunsford LD (2007) Radiosurgery for chordomas and chondrosarcomas of the skull base. J Neurosurg 107(4):758–764. doi:10.3171/JNS-07/10/0758

    Article  PubMed  Google Scholar 

  • Moss JM, Choi CY, Adler JR, Jr., Soltys SG, Gibbs IC, Chang SD (2009) Stereotactic radiosurgical treatment of cranial and spinal hemangioblastomas. Neurosurgery 65(1): 79–85 discussion 85. doi:10.1227/01.NEU.0000348015.51685.D2, 00006123-200907000-00019 [pii]

    Google Scholar 

  • Osaka S, Kodoh O, Sugita H, Osaka E, Yoshida Y, Ryu J (2006) Clinical significance of a wide excision policy for sacrococcygeal chordoma. J Cancer Res Clin Oncol 132(4):213–218. doi:10.1007/s00432-005-0067-3

    Article  PubMed  Google Scholar 

  • Rao G, Suki D, Chakrabarti I, Feiz-Erfan I, Mody MG, McCutcheon IE, Gokaslan Z, Patel S, Rhines LD (2008) Surgical management of primary and metastatic sarcoma of the mobile spine. J Neurosurg Spine 9(2):120–128. doi:10.3171/SPI/2008/9/8/120

    Article  PubMed  Google Scholar 

  • Rose PS, Laufer I, Boland PJ, Hanover A, Bilsky MH, Yamada J, Lis E (2009) Risk of fracture after single fraction image-guided intensity-modulated radiation therapy to spinal metastases. J Clin Oncol 27(30):5075–5079. JCO.2008.19.3508[pii], doi:10.1200/JCO.2008.19.3508

    Google Scholar 

  • Ryu SI, Chang SD, Kim DH, Murphy MJ, Le QT, Martin DP, Adler JR Jr (2001) Image-guided hypo-fractionated stereotactic radiosurgery to spinal lesions. Neurosurgery 49(4):838–846

    PubMed  CAS  Google Scholar 

  • Ryu SI, Kim DH, Chang SD (2003) Stereotactic radiosurgery for hemangiomas and ependymomas of the spinal cord. Neurosurg Focus 15(5):E10. 150510[pii]

    Google Scholar 

  • Sachdev S, Dodd RL, Chang SD, Soltys SG, Adler JR, Luxton G, Choi CY, Tupper L, Gibbs IC (2011) Stereotactic radiosurgery yields long-term control for benign intradural, extramedullary spinal tumors. Neurosurgery 69(3): 533–539 discussion 539. doi:10.1227/NEU.0b013e318218db23, 00006123-201109000-00002[pii]

    Google Scholar 

  • Schwab JH, Healey JH, Rose P, Casas-Ganem J, Boland PJ (2009) The surgical management of sacral chordomas. Spine Phila Pa 1976 34(24):2700–2704. doi:10.1097/BRS.0b013e3181bad11d, 00007632-200911150-00016[pii]

    Google Scholar 

  • Serizawa I, Imai R, Kamada T, Tsuji H, Kishimoto R, Kandatsu S, Tsujii H, Tatezaki S (2009) Changes in tumor volume of sacral chordoma after carbon ion radiotherapy. J Comput Assist Tomogr 33(5):795–798. doi:10.1097/RCT.0b013e31818f0d49, 00004728-200909000-00028[pii]

    Google Scholar 

  • Terezakis SA, Lovelock DM, Bilsky MH, Hunt MA, Zatcky J, Yamada Y (2007) Image-guided intensity-modulated photon radiotherapy using multifractionated regimen to paraspinal chordomas and rare sarcomas. Int J Radiat Oncol Biol Phys 69(5):1502–1508. S0360-3016(07)00846-2[pii], doi:10.1016/j.ijrobp.2007.05.019

    Google Scholar 

  • Thames HD, Suit HD (1986) Tumor radioresponsiveness versus fractionation sensitivity. Int J Radiat Oncol Biol Phys 12(4):687–691. 0360-3016(86)90081-7[pii]

    Google Scholar 

  • Wang VY, Potts M, Chou D (2008) Sarcoma and the spinal column. Neurosurg Clin N Am 19(1):71–80. S1042-3680(07)00095-2[pii], doi:10.1016/j.nec.2007.10.001

  • Wu AJ, Bilsky MH, Edgar MA, Yamada Y (2009) Near-complete pathological response of chordoma to high-dose single-fraction radiotherapy: case report. Neurosurgery 64(2): E389 390 discussion E390. doi:10.1227/01.NEU.0000338073.49649.1A, 00006123-200902000-00023[pii]

  • Yamada Y, Lovelock DM, Yenice KM, Bilsky MH, Hunt MA, Zatcky J, Leibel SA (2005) Multifractionated image-guided and stereotactic intensity-modulated radiotherapy of paraspinal tumors: a preliminary report. Int J Radiat Oncol Biol Phys 62(1):53–61. S0360-3016(04)02565-9[pii], doi:10.1016/j.ijrobp.2004.09.006

    Google Scholar 

  • Yamada Y, Bilsky MH, Lovelock DM, Venkatraman ES, Toner S, Johnson J, Zatcky J, Zelefsky MJ, Fuks Z (2008) High-dose, single-fraction image-guided intensity-modulated radiotherapy for metastatic spinal lesions. Int J Radiat Oncol Biol Phys 71(2):484–490. S0360-3016(07)04658-5[pii], doi:10.1016/j.ijrobp.2007.11.046

  • Yang JC, Chang AE, Baker AR, Sindelar WF, Danforth DN, Topalian SL, DeLaney T, Glatstein E, Steinberg SM, Merino MJ, Rosenberg SA (1998) Randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft tissue sarcomas of the extremity. J Clin Oncol 16(1):197–203

    PubMed  CAS  Google Scholar 

  • Zagars GK, Ballo MT (2003) Significance of dose in postoperative radiotherapy for soft tissue sarcoma. Int J Radiat Oncol Biol Phys 56(2):473–481. doi:10.1016/s0360-3016(02)04573-x

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA

    Brett Cox & Yoshiya Yamada

  2. Department of Radiation Oncology, Stanford University, Stanford, CA, USA

    Iris C. Gibbs

Authors
  1. Brett Cox
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Iris C. Gibbs
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yoshiya Yamada
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Brett Cox .

Editor information

Editors and Affiliations

  1. , Department of Radiation Oncology, Case Western Reserve University, Euclid Avenue 11100, Cleveland, 44106, Ohio, USA

    Simon S. Lo

  2. , Department of Radiation Oncology, Weil Cornell Medical College, Fannin, Ste#DB1-077 6565, Houston, 77030, Texas, USA

    Bin S. Teh

  3. Cancer Institute, Department of Radiation Oncology, National University Hospital, Lower Kent Ridge Road 5, Singapore, 119074, Singapore

    Jiade J. Lu

  4. , Department of Radiation Oncology, University of Colorado, Aurora, 80045, Colorado, USA

    Tracey E. Schefter

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Cox, B., Gibbs, I.C., Yamada, Y. (2012). Benign and Malignant Primary Spinal Tumors. In: Lo, S., Teh, B., Lu, J., Schefter, T. (eds) Stereotactic Body Radiation Therapy. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2011_534

Download citation

  • DOI: https://doi.org/10.1007/174_2011_534

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-25604-2

  • Online ISBN: 978-3-642-25605-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation