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Polymers in Nanomedicine pp 65–114Cite as

Biodegradable Polymeric Assemblies for Biomedical Materials

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Part of the book series: Advances in Polymer Science ((POLYMER,volume 247))

Abstract

Recently, self-assembled systems using biodegradable polymers at the nanometer scale, such as microspheres, nanospheres, polymer micelles, nanogels, and polymersomes, have attracted much attention especially in biomedical fields. To construct such self-assembled systems, it is extremely important to have precise control of intermolecular noncovalent interactions, such as hydrophobic interactions based on their amphiphilic molecular structures. Biodegradable polymers, especially aliphatic polyesters such as polylactide, polyglycolide, poly(ε-caplolactone) and their copolymers, have been used as biomedical materials for a long time. This chapter is mainly focused on aliphatic polyesters and related polymers, and reviews the synthetic methods for amphiphilic biodegradable polymers containing aliphatic polyesters as components. Moreover, the application of various types of self-assembly systems using amphiphilic biodegradable copolymers such as micro- or nanosized particles (microspheres, nanospheres, polymer micelles, nanogels, polymersomes), supramolecular physically interlocked systems, and stimuli-responsive systems for biomedical use such as drug delivery systems are also reviewed.

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Abbreviations

5FU:

5-Fluorouracil

Ala:

Alanine

Arg:

Arginine

Asp:

Aspartic acid

ATRP:

Atom transfer radical polymerization

BSA:

Bovine serum albumin

CD:

Cyclodextrin

cDP:

Cyclodepsipeptide

CHESG:

Cholesterol group-modified enzymatically synthesized glycogen

CHP:

Cholesterol–pullulan

CL:

ε-Caprolactone

CMC:

Critical micelle concentration

Cys:

Cysteine

DDS:

Drug delivery system

Dex:

Dextran

DLA:

d-Lactide

DMAE:

Dimethylaminoethyl

DTT:

Dithiothreitol

DXO:

1,4-Dioxepan-5-one

DXR:

Doxorubicin

EP:

Ethyl ethylene phosphate

EPR:

Enhanced permeability and retention

FDA:

Food and Drug Administration

FITC:

Fluorescein isothiocyanate

GA:

Glycolide

Glc:

Glycolic acid

Gly:

Glycine

HA:

Hyaluronic acid

HMDI:

Hexamethylene diisocyanate

HPEI:

Heparin–polyethyleneimine

IP:

Injectable polymer

IPP:

Isopropyl ethylene phosphate

LA:

Lactide

LCST:

Lower critical solution temperature

Leu:

Leucine

LH-RH:

Luteinizing hormone-releasing hormone

LLA:

l-Lactide

LSEC:

Liver sinusoidal endothelial cell

Lys:

Lysine

MA:

Malic acid

MDBE:

Malide dibenzyl ester

MeO:

Methoxy

ML:

Mevalonolactone

mRNA:

Messenger RNA

MS:

Microsphere

NCA:

N-carboxy anhydride

NIRF:

Near-infrared fluorescence

NMR:

Nuclear magnetic resonance

NS:

Nanosphere

o/w:

Oil in water

OCL:

Oligocaprolactone

Oct:

Octylate

P2VP:

Poly(2-vinylpyridine)

PAA:

Poly(acrylic acid)

PBD:

Poly(butadiene)

PBS:

Phosphate-buffered saline

PCL:

Poly(ε-caplolactone)

PDLA:

Poly(d-lactide)

PDP:

Polydepsipeptide

PEE:

Poly(ethyl ethylene)

PEG:

Poly(ethylene glycol)

PEGMA:

Poly(ethylene glycol) methacrylate

PEO:

Poly(ethyle oxide)

PGA:

Poly(glycolic acid), polyglycolide

PIC:

Polyion complex

PLA:

Poly(lactic acid), polylactide

PLGA:

Poly(lactide-co-glycolide)

PLLA:

Poly(l-lactide)

PMA:

Poly(malic acid)

PMPC:

Poly(2-methacryloyloxyethyl phosphorylcholine)

PNIPAAm:

Poly(N-isopropylacrylamide)

pPRX:

Pseudopolyrotaxane

PRX:

Polyrotaxane

PS:

Polystyrene

PTMC:

Poly(trimethylene carbonate)

PTX:

Paclitaxel

PVA:

Poly(vinyl alcohol)

RES:

Reticuloendothelial system

RGD:

Arginine–glycine–aspartic acid

ROP:

Ring-opening polymerization

SC:

Stereocomplex

Ser:

Serine

siRNA:

Small interfering RNA

SMP:

Shape-memory polymers

TCA:

Tricarboxylic acid

T g :

Glass transition temperature

THF:

Tetrahydrofuran

Thr:

Threonine

T m :

Melting temperature

TMC:

Trimethylene carbonate

TMS:

Trimethylsilyl

Tyr:

Tyrosine

w/o/w:

Water in oil in water

References

  1. Auras R, Lim LK, Selke EM, Tsuji H (2010) Poly(lactic acid): synthesis, structures, properties, and applications. Wiley, Hoboken, NJ

    Google Scholar 

  2. Jeong B, Kim SW, Bae YH (2002) Adv Drug Deliv Rev 54:37

    CAS  Google Scholar 

  3. Kissel T, Li Y, Unger F (2002) Adv Drug Deliv Rev 54:99

    CAS  Google Scholar 

  4. Luten J, van Nostrum CF, De Smedt SC, Hennink WE (2008) J Control Release 126:97

    CAS  Google Scholar 

  5. Ulery BD, Nair LS, Laurencin CT (2001) J Polym Sci B Polym Phys 49:832

    Google Scholar 

  6. Nair LS, Laurencin CT (2006) Adv Biochem Eng Biotechnol 102:47

    CAS  Google Scholar 

  7. Nair LS, Laurencin CT (2007) Prog Polym Sci 32:762

    CAS  Google Scholar 

  8. Uhrich KE, Cannizzaro SM, Langer RS, Shakesheff KM (1999) Chem Rev 99:3181

    CAS  Google Scholar 

  9. Drumright RE, Gruber PR, Henton DE (2000) Adv Mater 12:1841

    CAS  Google Scholar 

  10. Dechy-Cabaret O, Martin-Vaca B, Bourissou D (2004) Chem Rev 104:6147

    CAS  Google Scholar 

  11. Jacobson GB, Shinde R, Contag CH, Zare RN (2008) Angew Chem Int Ed 47:7880

    CAS  Google Scholar 

  12. Wei G, Ma PX (2008) Adv Funct Mater 18:3568

    CAS  Google Scholar 

  13. Albertsson AC, Varma IK, Lochab B, Finne-Wistrand A, Kumar K (2010) In: Auras R, Lim LK, Selke EM, Tsuji H (eds) Poly(lactic acid): synthesis, structures, properties, and applications. Wiley, Hoboken, NJ, p 43

    Google Scholar 

  14. Ouchi T, Ohya Y (2004) J Polym Sci A Polym Chem 42:453

    CAS  Google Scholar 

  15. Sun H, Meng F, Dias AA, Hendriks M, Feijen J, Zhong Z (2011) Biomacromolecules 12:1937

    CAS  Google Scholar 

  16. Oh JK (2011) Soft Matter 7:5096

    CAS  Google Scholar 

  17. Feng Y, Lu J, Behl M, Lendlein A (2010) Macromol Biosci 10:1008

    CAS  Google Scholar 

  18. Pounder RJ, Dove AP (2010) Polym Chem 1:260

    CAS  Google Scholar 

  19. Gaucher G, Marchessault RH, Leroux J-C (2010) J Control Release 143:2

    CAS  Google Scholar 

  20. Chvapil M (1977) J Biomed Mater Res 11:721

    CAS  Google Scholar 

  21. Tabata Y, Ikada Y (1988) Adv Drug Deliv Rev 31:287

    Google Scholar 

  22. Rousou JA, Engelman RM, Breyer RH (1984) Ann Thorac Surg 38:409

    CAS  Google Scholar 

  23. Gopferich A (1997) Macromolecules 30:2598

    Google Scholar 

  24. Coulembier O, Degee P, Hedrick JL, Dubois P (2006) Prog Polym Sci 31:723

    CAS  Google Scholar 

  25. Hill JW (1932) J Am Chem Soc 54:4105

    CAS  Google Scholar 

  26. Rosen HB, Chang J, Wnek GE, Linhardt RJ, Langer R (1983) Biomaterials 4:131

    CAS  Google Scholar 

  27. Domb AJ, Gallardo CF, Langer R (1989) Macromolecules 22:3200

    CAS  Google Scholar 

  28. Pospiech D, Jomber H, Jehnichen D, Haussler L, Eckstein K, Scheibner H, Janke A, Kricheldorf HR, Petermann O (2005) Biomacromolecules 6:439

    CAS  Google Scholar 

  29. Qi M, Li X, Yang Y, Zhou S (2008) Eur J Pharm Biopharm 70:445

    CAS  Google Scholar 

  30. Heller J (1985) J Cotrol Release 2:167

    CAS  Google Scholar 

  31. Wang C, Ge Q, Ting D, Nguyen D, Shen H-R, Chen J, Eisen HN, Heller J, Langer R, Putnam D (2004) Nat Mater 3:190

    CAS  Google Scholar 

  32. Nguyen DN, Raghavan SS, Tashima LM, Lin EC, Fredette SJ, Langer RS, Wang C (2008) Biomaterials 29:2783

    CAS  Google Scholar 

  33. Heffernan MJ, Murthy N (2005) Bioconjug Chem 16:1340

    CAS  Google Scholar 

  34. Lee S, Yang SC, Heffernan MJ, Taylor WR, Murthy N (2007) Bioconjug Chem 18:4

    CAS  Google Scholar 

  35. Allcock HR, Kugel RL (1965) J Am Chem Soc 87:4216

    CAS  Google Scholar 

  36. Laurencin CT, Koh HJ, Neenan TX, Allcock HR, Langer RJ (1987) Biomed Mater Res 21:1231

    CAS  Google Scholar 

  37. Lapienis G, Penczek S (1974) Macromolecules 7:166

    CAS  Google Scholar 

  38. Kaluzynski K, Libisowski J, Penczek S (1976) Macromolecules 9:365

    CAS  Google Scholar 

  39. Wang YC, Tang LY, Sun TM, Li C-H, Xiong M-H, Wang J (2008) Biomacromolecules 9:388

    CAS  Google Scholar 

  40. Iwasaki Y, Wachiralarpphaithoon C, Akiyoshi K (2007) Macromolecules 40:8136

    CAS  Google Scholar 

  41. Chen R, Curran SJ, Curran JM, Hunt JA (2006) Biomaterials 27:4453

    CAS  Google Scholar 

  42. Athanasiou KA, Agrawal CM, Barber FA, Burkhart SS (1998) Arthroscopy 14:726

    CAS  Google Scholar 

  43. Wang YC, Lin MC, Wang DM, Hsieh HJ (2003) Biomaterials 24:1047

    CAS  Google Scholar 

  44. Porter JR, Henson A, Popat KC (2009) Biomaterials 30:780

    CAS  Google Scholar 

  45. Mo XM, Xu CY, Kotaki M, Ramakrishna S (2004) Biomaterials 25:1883

    CAS  Google Scholar 

  46. Katz AR, Turner RJ (1970) Surg Gynecol Obstet 131:701

    CAS  Google Scholar 

  47. Echeverria EA, Jimenez J (1970) Surgery 131:1

    CAS  Google Scholar 

  48. Knight S, Erggelet C, Endres M, Sittinger M, Kaps C, Stussi E (2007) J Biomed Mater Res B Appl Biomater 83:50

    Google Scholar 

  49. Wang L, Dormer NH, Bonewald LF, Detamore MS (2010) Tissue Eng A 16:1937

    CAS  Google Scholar 

  50. Dunne N, Jack V, O’Hara R, Farrar D, Buchanan FJ (2010) Mater Sci Mater Med 21:2263

    CAS  Google Scholar 

  51. Pihlajamaki HK, Salminen ST, Tynninen O, Bostman OM, Laitinen O (2010) Calcif Tissue Int 87:90

    Google Scholar 

  52. Erggelet C, Neumann K, Endres M, Haberstroh K, Sittinger M, Kaps C (2007) Biomaterials 28:5570

    CAS  Google Scholar 

  53. Frisbie DD, Lu Y, Kawcak CE, DiCarlo EF, Binette F, McIlwraith CW (2009) Am J Sports Med 37:71S

    Google Scholar 

  54. Mahmoudifar N, Doran PM (2010) Biomaterials 31:3858

    CAS  Google Scholar 

  55. Pihlajamaki H, Tynninen O, Karjalainen P, Rokkanen PJ (2007) Biomed Mater Res A 81:987

    Google Scholar 

  56. Xu L, Cao D, Liu W, Zhou G, Zhang WJ, Cao Y (2010) Biomaterials 31:3894

    CAS  Google Scholar 

  57. Ohara T, Itaya T, Usami K, Ando Y, Sakurai H, Honda MJ, Ueda M, Kagami HJ (2010) Biomed Mater Res A 94:800

    Google Scholar 

  58. Darney PD, Monroe SE, Klaisle CM, Alvarado A (1989) Am J Obstet Gynecol 160:1292

    CAS  Google Scholar 

  59. Gunatillake P, Mayadunne R, Adhikari R (2006) Biotechnol Annu Rev 12:301

    CAS  Google Scholar 

  60. Pankajakshan D, Philipose LP, Palakkal M, Krishnan K, Krishnan LK (2008) J Biomed Mater Res B Appl Biomater 87:570

    Google Scholar 

  61. Plikk P, Malberg S, Albertsson A-C (2009) Biomacromolecules 10:1259

    CAS  Google Scholar 

  62. Zuo Y, Yang F, Wolke JGC, Li Y, Jansen JA (2010) Acta Biomater 6:1238

    CAS  Google Scholar 

  63. Li J, Li L, Yu H, Cao H, Gao C, Gong Y (2006) ASAIO J 52:321

    CAS  Google Scholar 

  64. Garkhal K, Verma S, Tikoo K, Kumar NJ (2007) Biomed Mater Res A 82:747

    Google Scholar 

  65. Guarino V, Ambrosio L (2008) Acta Biomater 4:1778

    CAS  Google Scholar 

  66. Gunatillake P, Mayadunne R, Adhikari R (2006) Biotechnol Annu Rev 12:301

    CAS  Google Scholar 

  67. Miller RA, Brady JM, Cutright DE (1977) J Biomed Mater Res 11:711

    CAS  Google Scholar 

  68. Middleton JC, Tipton A (1998) J Med Plast Biomater 31

    Google Scholar 

  69. Lu XL, Sun ZJ, Cai W, Gao ZY (2008) J Mater Sci Mater Med 19:395

    CAS  Google Scholar 

  70. Ito Y, Ochii Y, Fukushima K, Sugioka N, Takada K (2010) Int J Pharm 384:53

    CAS  Google Scholar 

  71. Lee WL, Foo WL, Widjaja E, Loo SC (2010) J Acta Biomater 6:1342

    CAS  Google Scholar 

  72. Rieger J, Freichels H, Imberty A, Putaux J-L, Delair T, Jerome C, Auzely-Velty R (2009) Biomacromolecules 10:651

    CAS  Google Scholar 

  73. Richter A, Olbrich C, Krause M, Kissel T (2010) Int J Pharm 389:244

    CAS  Google Scholar 

  74. Mathisen T, Masus K, Albertsson AC (1989) Macromolecules 22:3842

    CAS  Google Scholar 

  75. Ryner M, Albertsson AC (2002) Biomacromolecules 3:601

    CAS  Google Scholar 

  76. Finne A, Andronova A, Albertsson AC (2003) Biomcromolecules 4:1451

    Google Scholar 

  77. Miura Y, Aoyagi S, Kusada Y, Miyamoto K (1980) J Biomed Mater Res 14:619

    CAS  Google Scholar 

  78. Ouchi T, Fujino A (1989) Macromol Chem 190:1523

    CAS  Google Scholar 

  79. Ohya Y, Kobayashi H, Ouchi T (1991) React Polym 15:153

    CAS  Google Scholar 

  80. Ohya Y, Hirai K, Ouchi T (1992) Makromol Chem 193:1881

    CAS  Google Scholar 

  81. Braud C, Vert M (1985) Polym Bull 13:293

    CAS  Google Scholar 

  82. Fournie P, Domurado D, Guerin P, Braud C, Vert M, Madelmont JC (1990) J Bioact Compat Polym 5:381

    CAS  Google Scholar 

  83. Kimura Y, Shirotani K, Yamane H, Kitao T (1989) Kobunshi Ronbunshu 46:281

    CAS  Google Scholar 

  84. Kimura Y, Shirotani K, Yamane H, Kitao T (1993) Polymer 34:1741

    CAS  Google Scholar 

  85. Yamaoka T, Hotta Y, Kobayashi K, Kimura Y (1999) Int J Biol Macromol 25:265

    CAS  Google Scholar 

  86. Mahmud A, Xiong XB, Lavasanifar A (2006) Macromolecules 39:9419

    CAS  Google Scholar 

  87. Xiong XB, Mahmud A, Uludag H, Lavasanifar A (2008) Pharm Res 25:2555

    CAS  Google Scholar 

  88. Xiong XB, Ma Z, Lavasanifar A (2010) Biomaterials 31:757

    CAS  Google Scholar 

  89. Nottelet B, Tommaso CD, Mondon K, Gurny R, Moller M (2010) J Polym Sci A Polym Chem 48:3244

    CAS  Google Scholar 

  90. Pratt RC, Nederberg F, Waymouth RM, Hedrick JL (2008) Chem Commun 114

    Google Scholar 

  91. Fukushima K, Pratt RC, Nederberg F, Tan JPK, Yang YY, Waymouth RM, Hedrick JL (2008) Biomacromolecules 9:3051

    CAS  Google Scholar 

  92. Suriano F, Pratt R, Tan JPK, Wiradharma N, Nelson A, Yang YY, Dubois P, Hedrick JL (2010) Biomaterials 31:2637

    CAS  Google Scholar 

  93. Stewart FHC (1969) Aust J Chem 22:1291

    CAS  Google Scholar 

  94. Helder J, Kohn FE, Sato S, van den Berg JW, Feijen J (1985) Makromol Chem Rapid Commun 6:9

    CAS  Google Scholar 

  95. Helder J, Feijen J, Lee SJ, Kim SW (1986) Makromol Chem Rapid Commun 7:193

    CAS  Google Scholar 

  96. In’t Veld PJA, Dijkstra PJ, von Lochem JH, Feijen J (1990) Makromol Chem 191:1813

    Google Scholar 

  97. In’t Veld PJA, Wei-Ping Y, Klap R, Dijkstra PJ, Feijen J (1992) Makromol Chem 193:1927

    Google Scholar 

  98. EP 322154, Phizer Inc. invs: Fung FN, Glowaky RC (1989) Chemcal Abstr 113:103447

    Google Scholar 

  99. Samyn C, van Baylen M (1988) Makromol Chem Macromol Symp 19:255

    Google Scholar 

  100. Ouchi T, Shiratani M, Jinno M, Hirao M, Ohya Y (1993) Makromol Chem Rapid Commun 14:825

    CAS  Google Scholar 

  101. In’t Veld PJA, Dijkstra PJ, Feijen J (1993) Makromol Chem 193:2713

    Google Scholar 

  102. Ouchi T, Nozaki T, Okamoto Y, Shiratani M, Ohya Y (1996) Macromol Chem Phys 197:1823

    CAS  Google Scholar 

  103. Barrera DA, Zylstra E, Lansbury PT Jr, Langer R (1993) J Am Chem Soc 115:11010

    CAS  Google Scholar 

  104. Barrera DA, Zylstra E, Lansbury PT, Langer R (1995) Macromolecules 28:425

    CAS  Google Scholar 

  105. Cook AD, Hrkach JS, Gao NN, Johnson IM, Pajvani UB, Cannizzaro SM, Langer R (1997) J Biomed Mater Res 35:513

    CAS  Google Scholar 

  106. Ouchi T, Seike H, Nozaki T, Ohya Y (1998) J Polym Sci A Polym Chem 36:1283

    CAS  Google Scholar 

  107. Tasaka F, Miyazaki H, Ohya Y, Ouchi T (1999) Macromolecules 32:6386

    CAS  Google Scholar 

  108. Ohya Y, Matsunami H, Yamabe E, Ouchi T (2003) J Biomed Mater Res 65A:79

    CAS  Google Scholar 

  109. Ohya Y, Matsunami H, Ouchi T (2004) J Biomat Sci Polym Edn 15:111

    CAS  Google Scholar 

  110. Nagahama K, Ueda Y, Ouchi T, Ohya Y (2007) Biomacromolecules 8:3938

    CAS  Google Scholar 

  111. Nagahama K, Imai Y, Nakayama T, Ohmura J, Ouchi T, Ohya Y (2009) Polymer 50:3547

    CAS  Google Scholar 

  112. Gref R, Miralles G, Dellacherie E (1999) Polym Int 48:251

    CAS  Google Scholar 

  113. Zhu KJ, Xiangzhou L, Shilin YJ (1990) Appl Polym Sci 39:1

    CAS  Google Scholar 

  114. Penning JP, Dijkstra H, Pennings AJ (1993) Polymer 34:942

    CAS  Google Scholar 

  115. Zhu KJ, Bihai S, Shilin Y (1989) J Polym Sci A Polym Chem 27:2151

    CAS  Google Scholar 

  116. Piskin E, Kaitian X, Denkbas EB, Kucukyavuz ZJ (1995) Biomater Sci Polym Ed 7:359

    CAS  Google Scholar 

  117. Zhang X, Jackson JK, Burt HM (1996) Int J Pharm 132:195

    CAS  Google Scholar 

  118. Kimura Y, Matsuzaki Y, Yamane H, Kitao Y (1989) Polymer 30:1342

    CAS  Google Scholar 

  119. Vittaz M, Bazile D, Spenlehauer G, Verrecchia T, Veillard M, Puisieux F, Labarre D (1996) Biomaterials 17:1575

    CAS  Google Scholar 

  120. Rashkov I, Manolova N, Li SM, Espartero JL, Vert M (1996) Macromolecules 29:50

    CAS  Google Scholar 

  121. Park TG, Cohen S, Langer R (1992) Macromolecules 25:116

    CAS  Google Scholar 

  122. Chen X, McCarthy SP, Gross RA (1997) Macromolecules 30:4295

    CAS  Google Scholar 

  123. Li SM, Rashkov I, Espartero JL, Manolova N, Vert M (1996) Macromolecules 29:57

    CAS  Google Scholar 

  124. Hu DSG, Liu HJ (1994) Macromol Chem Phys 195:1213

    CAS  Google Scholar 

  125. Du YJ, Lemstra PJ, Nijenhui AJ, Aert HAMV, Bastiaansen C (1995) Macromolecules 28:2194

    Google Scholar 

  126. Hagan SA, Davis SS, Illum L, Davies MC, Garnett MC, Taylor DC, Irving MP, Tadros TF (1995) Langmuir 11:1482

    CAS  Google Scholar 

  127. Jeong B, Bae YH, Lee DS, Kim SW (1997) Nature 388:860

    CAS  Google Scholar 

  128. Lee DS, Shim MS, Kim SW, Lee H, Park I, Chang T (2001) Macromol Rapid Commun 22:587

    CAS  Google Scholar 

  129. Kissel T, Li YX, Volland C, Goerich S, Koneberg R (1996) J Control Release 39:315

    CAS  Google Scholar 

  130. Li Y, Kissel T (1998) Polymer 39:4421

    CAS  Google Scholar 

  131. Hiemstra C, Zhong Z, Dijkstra PJ, Feijen J (2005) Macromol Symp 224:119

    CAS  Google Scholar 

  132. Cai C, Wang L, Dong CM et al (2006) J Polym Sci A Polym Chem 44:2034

    CAS  Google Scholar 

  133. Chen W, Luo W, Wang S, Bei J (2003) Polym Adv Tech 14:245

    CAS  Google Scholar 

  134. Ohya Y, Nakai T, Nagahama K, Ouchi S, Tanaka S, Kato K (2006) J Bioact Compat Polym 21:557

    CAS  Google Scholar 

  135. Yamaoka T, Takahashi Y, Ohta T, Miyamoto M, Murakami A, Kimura Y (1999) J Polym Sci A Polym Chem 37:1513

    CAS  Google Scholar 

  136. Yamaoka T, Takahashi Y, Fujisato T, Lee CW, Tsuji T, Ohta T, Murakami A, Kimura Y (2001) J Biomed Mater Res 54:470

    CAS  Google Scholar 

  137. Lee J, Bae YH, Sohn YS, Jeong B (2006) Biomacromolecules 7:1729

    CAS  Google Scholar 

  138. Ouchi T, Miyazaki H, Arimura H, Tasaka F, Hamada A, Ohya Y (2002) J Polym Sci A Polym Chem 40:1218

    CAS  Google Scholar 

  139. Ouchi T, Miyazaki H, Arimura H, Tasaka F, Hamada A, Ohya Y (2002) J Polym Sci A Polym Chem 40:1426

    CAS  Google Scholar 

  140. Ouchi T, Seike H, Miyazaki H, Tasaka F, Ohya Y (2000) Design Monom Polym 3:279

    CAS  Google Scholar 

  141. Ouchi T, Uchida T, Arimura H, Ohya Y (2003) Biomacromolecules 4:477

    CAS  Google Scholar 

  142. Arimura H, Ohya Y, Ouchi T (2004) Macromol Rapid Commun 25:743

    CAS  Google Scholar 

  143. Arimura H, Ohya Y, Ouchi T (2005) Biomacromolecules 6:720

    CAS  Google Scholar 

  144. Schatz C, Lecommandoux S (2010) Macromol Rapid Commun 31:1664

    CAS  Google Scholar 

  145. Li BG, Zhang LM (2008) Carbohydr Polym 74:390

    CAS  Google Scholar 

  146. Liu JY, Zhang LM (2007) Carbohydr Polym 69:196

    CAS  Google Scholar 

  147. Sun H, Guo B, Li X, Cheng R, Meng F, Liu H, Zhong Z (2010) Biomacromolecules 11:848

    CAS  Google Scholar 

  148. Wang CH, Wang CH, Hsiue GH (2005) J Control Release 108:140

    CAS  Google Scholar 

  149. Kohori F, Sakai K, Aoyagi T, Yokoyama M, Sakurai Y, Okano T (1998) J Control Release 55:87

    CAS  Google Scholar 

  150. Nakayama M, Okano T, Miyazaki T, Kohori F, Sakai K, Yokoyama M (2006) J Control Release 115:46

    CAS  Google Scholar 

  151. You Y, Hong C, Wang W, Lu W, Pan C (2004) Macromolecules 37:9761

    CAS  Google Scholar 

  152. Hales M, Barner CK, Davis TP, Stenzel MM (2004) Langmuir 20:10809

    CAS  Google Scholar 

  153. Hsiue GH, Lo CL, Cheng CH, Lin CP, Huang CK, Chen HH (2007) J Polym Sci A Polym Chem 45:688

    CAS  Google Scholar 

  154. Huang CK, Lo CL, Chen HH, Hsiue GH (2007) Adv Funct Mater 17:2291

    CAS  Google Scholar 

  155. Watanabe J, Eriguchi T, Ishihara K (2002) Biomacromolecules 3:1375

    CAS  Google Scholar 

  156. Ohya Y, Maruhashi S, Ouchi T (1998) Macromolecules 31:4662

    CAS  Google Scholar 

  157. Ohya Y, Maruhashi S, Ouchi T (1998) Macromol Chem Phys 199:2017

    CAS  Google Scholar 

  158. Ouchi T, Kontani T, Ohya Y (2003) Polymer 44:3927

    CAS  Google Scholar 

  159. Ouchi T, Kontani T, Ohya Y (2003) J Polym Sci A Polym Chem 41:2462

    CAS  Google Scholar 

  160. Ouchi T, Kontani T, Saito T, Ohya Y (2005) J Biomater Sci Polym Ed 16:1035

    CAS  Google Scholar 

  161. Ouchi T, Kontani T, Aoki R, Saito T, Ohya Y (2006) J Polym Sci A Polym Chem 44:6402

    CAS  Google Scholar 

  162. Ouchi T, Minari T, Ohya Y (2004) J Polym Sci A Polym Chem 42:5482

    CAS  Google Scholar 

  163. Nagahama K, Mori Y, Ohya Y, Ouchi T (2007) Biomacromolecules 8:2135

    CAS  Google Scholar 

  164. Nagahama K, Ouchi T, Ohya Y (2008) Macromol Biosci 8:1044

    CAS  Google Scholar 

  165. de Jong SJ, De Smedt SC, Wahls MWC, Demeester J, Kettenes-van den Bosch JJ, Hennink WE (2000) Macromolecules 33:3680

    Google Scholar 

  166. de Jong SJ, van Eerdenbrugh B, van Nostrum CF, Kettenes-van den Bosch JJ, Hennink WE (2001) J Control Release 71:261

    Google Scholar 

  167. Hennink WE, De Jong SJ, Bos GW, Veldhuis TFJ, van Nostrum CF (2004) Int J Pharm 277:99

    CAS  Google Scholar 

  168. Ouchi T, Ichimura S, Ohya Y (2006) Polymer 47:429

    CAS  Google Scholar 

  169. Tasaka F, Ohya Y, Ouchi T (2001) Macromolecules 34:5494

    CAS  Google Scholar 

  170. Stolt M, Viljanmaa A, Sodergard A, Tormala P (2004) J Appl Polym Sci 91:196

    CAS  Google Scholar 

  171. Nagahama K, Ohya Y, Ouchi T (2006) Macromol Biosci 6:412

    CAS  Google Scholar 

  172. Nagahama K, Ohya Y, Ouchi T (2006) Polym J 38:852

    CAS  Google Scholar 

  173. Nagahama K, Nishimura Y, Ohya Y, Ouchi T (2007) Polymer 48:2649

    CAS  Google Scholar 

  174. Nagahama K, Shimizu K, Ouchi T, Ohya Y (2009) React Funct Polym 69:891

    CAS  Google Scholar 

  175. Tasaka F, Ohya Y, Ouchi T (2001) Macromol Rapid Commun 22:820

    CAS  Google Scholar 

  176. Ogawa Y, Okada H, Heya T (1989) J Pharm Pharmacol 41:439

    CAS  Google Scholar 

  177. Ogawa Y, Okada H, Yamamoto M, Shimamoto T (1988) Chem Pharm Bull 36:2576

    CAS  Google Scholar 

  178. Okada H (1997) Adv Drug Deliv Rev 28:43

    CAS  Google Scholar 

  179. Okada H, Heya T, Ogawa Y, Shimamoto T (1988) J Pharm Exp Ther 244:744

    CAS  Google Scholar 

  180. Ouchi T, Hamada A, Ohya Y (1999) Macromol Chem Phys 200:436

    CAS  Google Scholar 

  181. Ouchi T, Toyohara M, Arimura H, Ohya Y (2002) Biomacromolecules 3:885

    CAS  Google Scholar 

  182. Ouchi T, Sasakawa M, Arimura H, Ohya Y (2004) Polymer 45:1583

    CAS  Google Scholar 

  183. Ouchi T, Saito T, Kontani T, Ohya Y (2004) Macromol Biosci 4:458

    CAS  Google Scholar 

  184. Zhoua S, Liaob X, Lia X, Denga X, Lib H (2003) J Control Release 86:195

    Google Scholar 

  185. Liang H-F, Chen CT, Chen SC, Kulkarni AR, Chiu YL, Chen MC, Sung HW (2006) Biomaterials 27:2051

    CAS  Google Scholar 

  186. Saeed AO, Magnusson JP, Moradi E, Soliman M, Wang W, Stolnik S, Thurecht KJ, Howdle SM, Alexander C (2011) Bioconjug Chem 22:156

    CAS  Google Scholar 

  187. Liu SQ, Yang YY, Liu XM, Tong YW (2003) Biomacromolecules 4:1784

    CAS  Google Scholar 

  188. Yokoyama M, Inoue S, Kataoka K, Yui N, Okano T, Sakurai Y (1987) Makromol Chem Rapid Commun 8:431

    CAS  Google Scholar 

  189. Yokoyama M, Miyauchi M, Yamada N, Okano T, Sakurai Y, Kataoka K, Inoue S (1990) J Control Release 11:269

    CAS  Google Scholar 

  190. Yokoyama M, Okano T, Sakurai Y, Ekimoto H, Shibazaki C, Kataoka K (1991) Cancer Res 51:3229

    CAS  Google Scholar 

  191. Yokoyama M, Okano T, Sakurai Y, Fukushima S, Okamoto K, Kataoka K (1999) J Drug Target 7:171

    CAS  Google Scholar 

  192. Kataoka K, Harada A, Nagasaki Y (2001) Adv Drug Deliv Rev 47:113

    CAS  Google Scholar 

  193. Torchilin VP (2002) Adv Drug Deliv Rev 54:235

    CAS  Google Scholar 

  194. Blanazs A, Armes SP, Ryan AJ (2009) Macromol Rapid Commun 30:267

    CAS  Google Scholar 

  195. Shin HC, Alani AWG, Rao DA, Rockich NC, Kwon GS (2009) J Control Release 140:294

    CAS  Google Scholar 

  196. Mikihail AS, Allen C (2011) Biomacromolecules 11:1273

    Google Scholar 

  197. Ding H, Sumer BD, Kessinger CW, Dong Y, Huang G, Boothman DA (2011) Gao J 151:271

    CAS  Google Scholar 

  198. Kim SH, Tan JPK, Nederberg F, Fukushima K, Colson J, Yang C, Nelson A, Yang YY, Hedrick JL (2010) Biomaterials 31:8063

    CAS  Google Scholar 

  199. Wang F, Wang YC, Yan LF, Wang J (2009) Polymer 50:5048

    CAS  Google Scholar 

  200. Liu J, Pang Y, Huang W, Huang X, Meng L, Zhu X, Zhou Y, Yan D (2011) Biomacromolecules 12:1567

    CAS  Google Scholar 

  201. Ohya Y, Takeda S, Shibata Y, Ouchi T, Maruyama A (2010) Macromol Chem Phys 211:1750

    CAS  Google Scholar 

  202. Ohya Y, Takeda S, Shibata Y, Ouchi T, Kano A, Iwata T, Mochizuki S, Taniwaki Y, Maruyama A (2011) J Control Release155:104

    Google Scholar 

  203. Discher DE, Eisenberg A (2002) Science 297:967

    CAS  Google Scholar 

  204. Meier W (2000) Chem Soc Rev 29:295

    CAS  Google Scholar 

  205. Torchilin VP (2005) Nat Rev Drug Discov 4:145

    CAS  Google Scholar 

  206. Onaca O, Enea R, Hughes DW, Meier W (2009) Macromol Biosci 9:129

    CAS  Google Scholar 

  207. Christian DA, Cai S, Bowen DM, Kim Y, Pajerowski D, Discher DE (2009) Eur J Pharm Biopharm 71:463

    CAS  Google Scholar 

  208. De Cock LJ, De Koker S, De Geest BG, Grooten J, Vervaet C, Remon JP, Sukhorukov GB, Antipina MN (2010) Angew Chem Int Ed 49:6954

    Google Scholar 

  209. Chang TMS (2005) Nat Rev Drug Discov 4:221

    CAS  Google Scholar 

  210. Kishimura A, Koide A, Osada K, Yamasaki Y, Kataoka K (2007) Angew Chem Int Ed 46:6085

    CAS  Google Scholar 

  211. Price AD, Zelikin AN, Wang Y, Caruso F (2009) Angew Chem Int Ed 48:329

    CAS  Google Scholar 

  212. Johnston APR, Zelikin AN, Caruso F (2007) Adv Mater 19:3727

    CAS  Google Scholar 

  213. Bally M, Bailey K, Sugahara K, Grieshaber D, Vörös J, Stäler B (2010) Small 6:2481

    CAS  Google Scholar 

  214. Holowka E, Sun VZ, Kamei DT, Deming TJ (2007) Nat Mater 6:52

    CAS  Google Scholar 

  215. Bangham AD (1993) Chem Phys Lipids 64:275

    CAS  Google Scholar 

  216. Ringsdorf H, Schlarb B, Venzmer J (1988) Angew Chem Int Ed 27:113

    Google Scholar 

  217. Yoshina-Ishii C, Miller GP, Kraft ML, Kool ET, Boxer SG (2005) J Am Chem Soc 127:1356

    CAS  Google Scholar 

  218. Discher BM, Won YY, Ege DS, Lee JCM, Bates FS, Discher DE, Hammer DA (1999) Science 284:1143

    CAS  Google Scholar 

  219. Lee JC, Bermudez H, Discher BM, Sheehan MA, Won YY, Bates FS, Discher DE (2001) Biotechnol Bioeng 73:135

    CAS  Google Scholar 

  220. Lee Y, Chang JB, Kim HK, Park TG (2006) Macromol Res 14:359

    CAS  Google Scholar 

  221. Pata V, Dan N (2003) Biophys J 85:2111

    CAS  Google Scholar 

  222. Wu J, Eisenberg A (2006) J Am Chem Soc 128:2880

    CAS  Google Scholar 

  223. Borchert U, Lipprandt U, Bilang M, Kimpfler A, Rank A, Peschka-Suss R, Schubert R, Lindner P, Forster S (2006) Langmuir 22:5843

    CAS  Google Scholar 

  224. Checot F, Lecommandoux S, Gnanou Y, Klok HA (2002) Angew Chem Int Ed 41:1339

    CAS  Google Scholar 

  225. Qin SH, Geng Y, Discher DE, Yang S (2006) Adv Mater 18:2905

    CAS  Google Scholar 

  226. Meng FH, Hiemstra C, Engbers GHM, Feijen J (2003) Macromolecules 36:3004

    CAS  Google Scholar 

  227. Meng FH, Engbers GHM, Feijen J (2005) J Control Release 101:187

    CAS  Google Scholar 

  228. Ghoroghchian PP, Li GZ, Levine DH, Davis KP, Bates FS, Hammer DA, Therien MJ (2006) Macromolecules 39:1673

    CAS  Google Scholar 

  229. Ahmed F, Discher DE (2004) J Control Release 96:37

    Google Scholar 

  230. Ahmed F, Pakunlu RI, Srinivas G, Brannan A, Bates F, Klein ML, Minko T, Discher DE (2006) Mol Pharm 3:340

    Google Scholar 

  231. Rameez S, Alosta H, Palmer AF (2008) Bioconjug Chem 19:1025

    CAS  Google Scholar 

  232. Kim Y, Tewari M, Pajerowski JD, Cai SS, Sen S, Williams J, Sirsi S, Lutz G, Discher DE (2009) J Control Release 134:132

    CAS  Google Scholar 

  233. Nagahama K, Saito T, Ouchi T, Ohya Y (2011) J Biomed Sci Polym Ed 22:407

    CAS  Google Scholar 

  234. Nagahama K, Ohmura J, Sakaue H, Ouchi T, Ohya Y, Yui N (2010) Chem Lett 39:250

    CAS  Google Scholar 

  235. Ooya T, Eguchi M, Yui N (2003) J Am Chem Soc 125:13016

    CAS  Google Scholar 

  236. Yui N (2009) Macromol Symp 279:158

    CAS  Google Scholar 

  237. Bellomo EG, Wyrsta MD, Pakstis L, Pochan DJ, Deming T (2004) Nat Mater 3:244

    CAS  Google Scholar 

  238. Makino A, Yamahara R, Ozeki E, Kimura S (2007) Chem Lett 36:1220

    Google Scholar 

  239. Tanisaka H, Kizaka-Kondoh S, Makino A, Tanaka S, Hiraoka M, Kimura S (2008) Bioconjug Chem 19:109

    Google Scholar 

  240. Koide A, Kishimura A, Osada K, Jang WD, Yamasaki Y, Kataoka K (2006) J Am Chem Soc 128:5988

    CAS  Google Scholar 

  241. Anraku Y, Kishimura A, Oba M, Yamasaki Y, Kataoka K (2010) J Am Chem Soc 131:1631

    Google Scholar 

  242. Makino A, Kimura S (2011) React Funct Polym 71:272

    CAS  Google Scholar 

  243. Makino A, Kizaka-Kondoh S, Yamahara R, Hara I, Kanzaki T, Ozeki E, Hiraoka M, Kimura S (2009) Biomaterials 30:5156

    Google Scholar 

  244. Matsumura Y, Maeda H (1986) Cancer Res 46:6387

    CAS  Google Scholar 

  245. Maeda H, Matsumura Y (1989) Crit Rev Ther Drug Carrier Syst 6:193

    CAS  Google Scholar 

  246. Oha JK, Lee DI, Park JM (2009) Prog Polym Sci 34:1261

    Google Scholar 

  247. Sasaki Y, Akiyoshi K (2010) Chem Rec 10:366

    CAS  Google Scholar 

  248. van de Manakker F, Vermonden T, van Nostrum CF, Hennink WE (2009) Biomacromolecules 10:3157

    Google Scholar 

  249. Kabanov AV, Vinogradov SV (2009) Angew Chem Int Ed 48:5418

    CAS  Google Scholar 

  250. Akiyoshi K, Deguchi N, Moriguchi N, Yamaguchi S, Sunamoto J (1993) Macromolecules 26:3062

    CAS  Google Scholar 

  251. Akiyoshi K, Ueminami A, Kurumada S, Nomura Y (2000) Macromolecules 33:6752

    CAS  Google Scholar 

  252. Akiyama E, Morimoto N, Kujawa P, Ozawa Y, Winnik FM, Akiyoshi K (2007) Biomacromolecules 8:2366

    CAS  Google Scholar 

  253. Lee KY, Jo WH, Kwon IC, Kim Y, Jeong SY (1998) Macromolecules 31:378

    CAS  Google Scholar 

  254. Nichifor M, Lopes A, Carpov A, Melo E (1999) Macromolecules 32:7078

    CAS  Google Scholar 

  255. Yusa S, Kamachi M, Morishima Y (1998) Langmuir 14:6059

    CAS  Google Scholar 

  256. Morimoto N, Qiu XP, Winnik FM, Akiyoshi K (2008) Macromolecules 41:5985

    CAS  Google Scholar 

  257. Sawada S, Akiyoshi K (2010) Macromol Biosci 10:353

    CAS  Google Scholar 

  258. Takahashi H, Sawada S, Akiyoshi K (2011) ACS Nano 5:337

    CAS  Google Scholar 

  259. Gou ML, Men K, Zhang J, Li YH, Song J, Luo S, Shi HS, Wen YJ, Guo G, Huang MJ, Zhao X, Qian ZY, Wei YQ (2010) ACS Nano 4:5573

    CAS  Google Scholar 

  260. Li F, Bae B, Na K (2010) Bioconjug Chem 21:1312

    CAS  Google Scholar 

  261. Tsuji H, Ikada Y (1993) Macromolecules 26:6918

    CAS  Google Scholar 

  262. Nagahama K, Hashizume M, Yamamoto H, Ouchi T, Ohya Y (2009) Langmuir 25:9734

    CAS  Google Scholar 

  263. Harada A, Li J, Kamachi M (1992) Nature 356:325

    CAS  Google Scholar 

  264. Nepogodiev SA, Stoddart JF (1998) Chem Rev 98:1959

    CAS  Google Scholar 

  265. Wenz G, Han BH, Müller A (2006) Chem Rev 106:782

    CAS  Google Scholar 

  266. Harada A, Hashidzume A, Yamaguchi H, Takashima Y (2009) Chem Rev 109:5974

    CAS  Google Scholar 

  267. Loethen S, Kim JM, Thompson DH (2007) Polym Rev 47:383

    CAS  Google Scholar 

  268. Li J, Loh XJ (2008) Adv Drug Deliv Rev 60:1000

    CAS  Google Scholar 

  269. Ooya T, Yui N (1998) Macromol Chem Phys 199:2311

    CAS  Google Scholar 

  270. Ooya T, Arizono K, Yui N (2000) Polym Adv Technol 11:642

    CAS  Google Scholar 

  271. Ooya T, Eguchi M, Yui N (2001) Biomacromolecules 2:200

    CAS  Google Scholar 

  272. Watanabe J, Ooya T, Yui N (1998) Chem Lett 1031

    Google Scholar 

  273. Watanabe J, Ooya T, Yui N (1999) J Biomater Sci Polym Ed 10:1275

    CAS  Google Scholar 

  274. Tachaboonyakiat W, Furubayashi T, Katoh M, Ooya T, Yui N (2004) J Biomater Sci Polym Ed 15:1389

    CAS  Google Scholar 

  275. Loethen S, Ooya T, Choi HS, Yui N, Thompson DH (2006) Biomacromolecules 7:2501

    CAS  Google Scholar 

  276. Ooya T, Ito A, Yui N (2005) Macromol Biosci 5:379

    CAS  Google Scholar 

  277. Ooya T, Choi HS, Yamashita A, Yui N, Sugaya Y, Kano A, Maruyama A, Akita H, Ito R, Kogure K, Harashima H (2006) J Am Chem Soc 128:3852

    CAS  Google Scholar 

  278. Harada A, Nishiyama T, Kawaguchi Y, Okada M, Kamachi M (1997) Macromolecules 30:7115

    CAS  Google Scholar 

  279. Harada A, Kawaguchi Y, Nishiyama T, Kamachi M (1997) Macromol Rapid Commun 18:535

    CAS  Google Scholar 

  280. Huang L, Allen E, Tonelli AE (1998) Polymer 39:4857

    CAS  Google Scholar 

  281. Kawaguchi Y, Nishiyama T, Okada M, Kamachi M, Harada A (2000) Macromolecules 33:4472

    CAS  Google Scholar 

  282. Rusa CC, Tonelli AE (2000) Macromolecules 33:5321

    CAS  Google Scholar 

  283. Shuai X, Porbeni FE, Wei M, Bullions T, Tonelli AE (2002) Macromolecules 35:3126

    CAS  Google Scholar 

  284. Shuai X, Porbeni FE, Wei M, Bullions T, Tonelli AE (2002) Macromolecules 35:3778

    CAS  Google Scholar 

  285. Lu J, Shin ID, Nojima S, Tonelli AE (2000) Polymer 41:5871

    CAS  Google Scholar 

  286. Shuai X, Porbeni FE, Wei M, Shin ID, Tonelli AE (2001) Macromolecules 34:7355

    CAS  Google Scholar 

  287. Shuai X, Porbeni FE, Wei M, Bullions T, Tonelli AE (2002) Macromolecules 35:2401

    CAS  Google Scholar 

  288. Choi HS, Ooya T, Sasaki S, Yui N, Ohya Y, Nakai T, Ouchi T (2003) Macromolecules 36:9313

    CAS  Google Scholar 

  289. Shuai X, Merdan T, Unger F, Kissel T (2005) Bioconjug Chem 16:322

    CAS  Google Scholar 

  290. Liu KL, Goh SH, Li J (2008) Macromolecules 41:6027

    CAS  Google Scholar 

  291. Ohya Y, Takamido S, Nagahama K, Ouchi T, Ooya T, Katoono R, Yui N (2007) Macromolecules 40:6441

    CAS  Google Scholar 

  292. Ohya Y, Takamido S, Nagahama K, Ouchi T, Katoono R, Yui N (2009) Biomacromolecules 10:2261

    CAS  Google Scholar 

  293. Wu DQ, Wang T, Lu B, Xu XD, Cheng SX, Jiang XJ, Zhang XZ, Zhuo RX (2008) Langmuir 24:10306

    CAS  Google Scholar 

  294. Hoffman AS (2002) Adv Drug Deliv Rev 54:3

    CAS  Google Scholar 

  295. Jeong B, Kim SW, Bae YH (2002) Adv Drug Deliv Rev 54:37

    CAS  Google Scholar 

  296. Heskins M, Guillent JE, James E (1968) J Macromol Sci Chem A2:1441

    Google Scholar 

  297. Chen GH, Hoffman AS (1995) Nature 373:49

    CAS  Google Scholar 

  298. Yamato M, Akiyama Y, Kobayashi J, Yang J, Kikuchi A, Okano T (2007) Prog Polym Sci 32:1123

    CAS  Google Scholar 

  299. Yoshida R, Uchida K, Kaneko Y, Sakai K, Kikuchi A, Sakurai Y, Okano T (1995) Nature 374:240

    CAS  Google Scholar 

  300. Heras CDL, Pennadam S, Alexander C (2005) Chem Soc Rev 34:276

    Google Scholar 

  301. Tachibana Y, Kurisawa M, Uyama H, Kakuchi T, Kobayashi S (2003) Chem Commun 106

    Google Scholar 

  302. Shimokuri T, Kaneko T, Serizawa T, Akashi M (2004) Macromol Biosci 4:407

    CAS  Google Scholar 

  303. Shimokuri T, Kaneko T, Akashi M (2004) J Polym Sci A Polym Chem 42:4492

    CAS  Google Scholar 

  304. Ohya Y, Toyohara M, Sasakawa M, Arimura H, Ouchi T (2005) Macromol Biosci 5:273

    CAS  Google Scholar 

  305. Renier ML, Kohn DH (1997) J Biomed Mater Res 34:95

    CAS  Google Scholar 

  306. Nguyen MK, Lee DS (2010) Macromol Biosci 10:563

    CAS  Google Scholar 

  307. Joo MK, Park MH, Choi BG, Jeong B (2009) J Mater Chem 19:5891

    CAS  Google Scholar 

  308. Jeong B, Bae YH, Kim SW (2000) J Control Release 63:155

    CAS  Google Scholar 

  309. Kim YJ, Choi S, Koh JJ, Lee M, Ko KS, Kim SW (2001) Pharm Res 18:548

    CAS  Google Scholar 

  310. Kim HK, Shim WS, Kim SE, Lee K, Kang E, Kim J, Kim K, Kwon IC, Lee DS (2009) Tissue Eng 15:923

    CAS  Google Scholar 

  311. Duvvuri S, Janoria KG, Mitra AK (2005) J Control Release 108:282

    CAS  Google Scholar 

  312. Li Z, Ning W, Wang J, Choi A, Lee P, Tyagi P, Huang L (2003) Pharm Res 20:884

    CAS  Google Scholar 

  313. Fujiwara T, Mukose T, Yamaoka T, Yamane H, Sakurai S, Kimura Y (2001) Macromol Biosci 1:204

    CAS  Google Scholar 

  314. Mukose T, Fujiwara T, Nakano J, Taniguchi I, Miyamoto M, Kimura Y, Teraoka I, Lee CW (2004) Macromol Biosci 4:361

    CAS  Google Scholar 

  315. Choi BG, Park MH, Cho SH, Joo MK, Oh HJ, Kim EH, Park K, Han DK, Jeong B (2010) Biomaterials 31:9266

    Google Scholar 

  316. Ohya Y, Yamamoto H, Nagahama K, Ouchi T (2009) J Polym Sci A Polym Chem 47:3892

    CAS  Google Scholar 

  317. Park K, Song S (2005) J Biomater Sci Polym Ed 16:1421

    CAS  Google Scholar 

  318. Park K, Song S (2006) J Biosci Bioeng 101:238

    CAS  Google Scholar 

  319. Jeong B, Lee KM, Gutowska A, An YH (2002) Biomacromolecules 3:865

    CAS  Google Scholar 

  320. Nagahama K, Ouchi T, Ohya Y (2008) Adv Funct Mater 18:1220

    CAS  Google Scholar 

  321. Nagahama K, Fujiura K, Enami S, Ouchi T, Ohya Y (2008) J Polym Sci A Polym Chem 46:6317

    CAS  Google Scholar 

  322. Osada Y, Matsuda A (1995) Nature 376:219

    CAS  Google Scholar 

  323. Langer R, Tirrell DA (2004) Nature 428:487

    CAS  Google Scholar 

  324. Lendlein A, Langer R (2002) Science 296:1673

    Google Scholar 

  325. Lendlein A, Kelch S (2002) Angew Chem Int Ed 41:2035

    Google Scholar 

  326. Lendlein A, Schmidt AM, Langer R (2001) Proc Natl Acad Sci USA 98:842

    CAS  Google Scholar 

  327. Rickert D, Lendlein A, Kelch S, Moses MA, Franke RP (2005) Clin Hemorheol Microcirc 32:117

    CAS  Google Scholar 

  328. Kelch S, Steuer S, Schmidt AM, Lendlein A (2007) Biomacromolecules 8:1018

    CAS  Google Scholar 

  329. Neuss S, Blomenkamp I, Stainforth R, Boltersdorf D, Jansen M, Butz N, Perez-Bouza A, Knüchel R (2009) Biomaterials 30:1697

    CAS  Google Scholar 

  330. Nagahama K, Ueda Y, Ouchi T, Ohya Y (2009) Biomacromolecules 10:1789

    CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, Kansai University, 3-3-35 Yamate-cho, Suita, Osaka, 564-8680, Japan

    Yuichi Ohya

  2. Organization for Research and Development of Innovative Science and Technology (ORDIST), Kansai University, 3-3-35 Yamate-cho, Suita, Osaka, 564-8680, Japan

    Yuichi Ohya & Akihiro Takahashi

  3. Department of Nanobiochemistry, Frontiers of Innovative Research in Science and Technology (FIRST), Konan University, 7-1-20 Minatojima-Minamimachi, Chuo-ku, Kobe, 650-0047, Japan

    Koji Nagahama

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  1. Yuichi Ohya
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  2. Akihiro Takahashi
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  3. Koji Nagahama
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Editors and Affiliations

  1. Dept. of Polymer Science and Engineering, Kyoto Institute of Technology, Goshokaido-cho, Matsugasaki, Kyoto, 606-8585, Japan

    Shigeru Kunugi

  2. Department of Biomedical Engineering, National Cerebral and Cardiovascular Cen, Fujisirodai 5-7-1, Osaka, 565-8565, Japan

    Tetsuji Yamaoka

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Ohya, Y., Takahashi, A., Nagahama, K. (2011). Biodegradable Polymeric Assemblies for Biomedical Materials. In: Kunugi, S., Yamaoka, T. (eds) Polymers in Nanomedicine. Advances in Polymer Science, vol 247. Springer, Berlin, Heidelberg. https://doi.org/10.1007/12_2011_160

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