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Branching Morphogenesis pp 186–201Cite as

Uterine Glands

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Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Abstract

This chapter focuses on the comparative development and mechanisms regulating branching morphogenesis of endometrial glands in the mammalian uterus. All uteri contain endometrial glands that secrete substances, termed histotroph, essential for conceptus (embryo/fetus and associated extraembryonic membranes) survival, implantation, development and growth. Uterine adenogenesis is the process whereby endometrial glands develop and is primarily a postnatal event in domestic livestock, rodents and humans. Adenogenesis involves initial differentiation and budding of glandular epithelium from luminal epithelium, followed by invagination and extensive tubular coiling and branching morphogenesis through the endometrial stroma to the myometrium. The endocrine, cellular and molecular mechanisms regulating uterine adenogenesis are not well defined in any species. In neonatal rodents and pigs, uterine adenogenesis is ovary- and steroid- independent. Estrogen receptor alpha regulates the initial stage of endometrial gland budding and differentiation in the pig, but not rodent or sheep. However, the ovary and uterine estrogen receptor alpha regulate later stages of endometrial gland coiling and branching morphogenesis in sheep. In rodents, pigs and sheep, uterine adenogenesis is a critical period that is sensitive to the detrimental effects of steroid-based endocrine disruptors, which cause functional defects in the adult. In neonatal sheep, pituitary prolactin acts on receptors, expressed exclusively in the nascent and proliferating endometrial glands, to regulate their coiling and branching morphogenetic differentiation. Following postnatal adenogenesis, humans and menstruating primates undergo recurrent endometrial growth and uterine gland branching morphogenesis during the proliferative phase after menstruation. This regrowth is regulated by ovarian estrogen and intrinsic growth factors. In domestic animals, extensive endometrial gland hyperplasia and hypertrophy occur during gestation to provide increasing histotrophicnutrition for fetoplacental growth. In sheep, the sequential actions of ovarian steroid hormones (estrogen and progesterone), the pregnancy recognition signal (interferon tau), and somatolactogenic hormones from the placenta (placental lactogen and growth hormone) constitute a servomechanism that directly regulates endometrial gland morphogenesis and terminal differentiated function. An increased understanding of the mechanisms regulating uterine gland branching morphogenesis is important, because aberrations in this important process can cause infertility, fetal growth retardation, and disease.

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References

  1. Amoroso EC. Placentation. In: Parkes AS, ed. Marshall’s Physiology of Reproduction. 3rd ed. London: Longmans Green, 1952: 2:127–311.

    Google Scholar 

  2. Bazer FW. Uterine protein secretions: Relationship to development of the conceptus. J Anim Sci 1975; 41:1376–1382.

    PubMed  CAS  Google Scholar 

  3. Kane MT, Morgan PM, Coonan C. Peptide growth factors and preimplantation development. Hum Reprod Update 1997; 3:137–157.

    Article  PubMed  CAS  Google Scholar 

  4. Bonnett R. Die uterinmilch und ihre bedeutung fár die fruct. Beträge zur Biologie als Fetgabe dem Anatomen und Physiologen. Th von Bischoff Stuttgart 1882; 221–263.

    Google Scholar 

  5. Bazer FW, Roberts RM, Thatcher WW. Actions of hormones on the uterus and effect of conceptus development. J Anim Sci 1979; 49(Suppl 2):35–45.

    PubMed  Google Scholar 

  6. Bell SC. Secretory endometrial/decidual proteins and their function in early pregnancy. J Reprod Fertil 1988; 36(Suppl):109–125.

    CAS  Google Scholar 

  7. Roberts RM, Bazer FW. The function of uterine secretions. J Reprod Fertil 1988; 82:875–892.

    Article  PubMed  CAS  Google Scholar 

  8. Bell SC, Drife JO. Secretory proteins of the endometrium-potential markers for endometrial dysfunction. Baillieres Clin Obstet Gynaecol 1989; 3:271–291.

    Article  PubMed  CAS  Google Scholar 

  9. Fazleabas AT, Donnelly KM, Hild-Petito S et al. Secretory proteins of the baboon (Papio anubis) endometrium: Regulation during the menstrual cycle and early pregnancy. Hum Reprod Update 1997; 3:553–559.

    Article  PubMed  CAS  Google Scholar 

  10. Carson DD, Bagchi I, Dey SK et al. Embryo implantation. Dev Biol 2000; 223:217–237.

    Article  PubMed  CAS  Google Scholar 

  11. Bagchi IC, Li Q, Cheon YP. Role of steroid hormone-regulated genes in implantation. NY. Ann Acad Sci 2001; 943:68–76.

    Article  CAS  Google Scholar 

  12. Gray CA, Bartol FF, Tarleton BJ et al. Developmental biology of uterine glands. Biol Reprod 2001; 65:1311–1323.

    Article  PubMed  CAS  Google Scholar 

  13. Burton GJ, Watson AL, Hempstock J et al. Uterine glands provide histiotrophic nutrition for the human fetus during the first trimester of pregnancy. J Clin Endocrinol Metab 2002; 87:2954–2959.

    Article  PubMed  CAS  Google Scholar 

  14. Given RL, Enders AC. The endometrium of delayed and early implantation. In: Wynn RM, Jollie WP, eds. Biology of the Uterus. 2nd ed. New York: Plenum Medical Book Company, 1989:175–231.

    Google Scholar 

  15. Renfree MB. Diapause, pregnancy, and parturition in Australian marsupials. J Exp Zool 1993; 266:450–462.

    Article  PubMed  CAS  Google Scholar 

  16. Gray CA, Taylor KM, Ramsey WS et al. Endometrial glands are required for preimplantation conceptus elongation and survival. Biol Reprod 2001; 64:1608–1613.

    Article  PubMed  CAS  Google Scholar 

  17. Gray CA, Burghardt RC, Johnson GA et al. Evidence that an absence of endometrial gland secretions in uterine gland knockout (UGKO) ewes compromises conceptus survival and elongation. Reproduction 2002; 124:289–300.

    Article  PubMed  CAS  Google Scholar 

  18. Bartol FF, Wiley AA, Floyd JG et al. Uterine differentiation as a foundation for subsequent fertility. J Reprod Fertil Suppl 1999; 53:284–300.

    Google Scholar 

  19. Wimsatt WA. New histological observations on the placenta of the sheep. Am J Anat 1950; 87:391–436.

    Article  PubMed  CAS  Google Scholar 

  20. Stewart MD, Johnson GA, Gray CA et al. Prolactin receptor and UTMP expression in the ovine endometrium during the estrous cycle and pregnancy. Biol Reprod 2000; 62:1779–1789.

    Article  PubMed  CAS  Google Scholar 

  21. King GJ, Atkinson BA, Robertson HA. Development of the intercaruncular areas during early gestation and establishment of the bovine placenta. J Reprod Fertil 1981; 61:469–474.

    Article  PubMed  CAS  Google Scholar 

  22. Perry JS, Crombie PR. Ultrastructure of the uterine glands of the pig. J Anat 1982; 134:339–350.

    PubMed  CAS  Google Scholar 

  23. Sinowatz F, Friess AE. Uterine glands of the pig during pregnancy. An ultrastructural and cytochemical study. Anat Embryol (Berl) 1983; 166:121–134.

    Article  CAS  Google Scholar 

  24. van Niekerk CH, Allen WR. Early embryonic development in the horse. J Reprod Fertil Suppl 1975; 23:495–498.

    PubMed  Google Scholar 

  25. Gerstenberg C, Allen WR. Development of the equine endometrial glands from fetal life to ovarian cycling. J Reprod Fert 1999; 56(Suppl):317–326.

    Google Scholar 

  26. Samuel CA, Allen WR, Steven DH. Studies on the equine placenta III. Ultrastructure of the uterine glands and the overlying trophoblast. J Reprod Fert 1977; 51:433–437.

    Article  CAS  Google Scholar 

  27. Dantzer V. Scanning electron microscopy of the exposed surfaces of the porcine placenta. Acta Anat 1984; 188:96–106.

    Google Scholar 

  28. Burton GJ, Jaunaiux E. Maternal vascularization of the human placenta: Does the embryo develop in a hypoxic environment. Gynecol Obstet Fertil 2001; 29:503–508.

    Article  PubMed  CAS  Google Scholar 

  29. Davies J. Comparative embryology. In: Wynn RM, ed. Cellular Biology of the Uterus. New York: Appleton-Century Crofts, 1967:13–32.

    Google Scholar 

  30. Mossman HA. Vertebrate fetal membranes. New Brunswick, NJ: Rutgers University Press, 1987.

    Google Scholar 

  31. Bartol FF, Wiley AA, Spencer TE et al. Early uterine development in pigs. Reprod Fert Suppl 1993; 48:99–116,100.

    CAS  Google Scholar 

  32. Atkinson BA, King GJ, Amoroso EC. Development of the caruncular and intercaruncular regions in the bovine endometrium. Biol Reprod 1984; 30:763–764.

    Article  PubMed  CAS  Google Scholar 

  33. Wiley AA, Bartol FF, Barron DH. Histogenesis of the ovine uterus. J Anim Sci 1987; 64:1262–1269.

    PubMed  CAS  Google Scholar 

  34. Kennedy JP, Worthington CA, Cole ER. The post-natal development of the ovary and uterus of the merino lamb. J Reprod Fertil 1974; 36:275–282.

    Article  PubMed  CAS  Google Scholar 

  35. Bartol FF, Wiley AA, Goodlett DR. Ovine uterine morphogenesis: Histochemical aspects of endometrial development in the fetus and neonate. J Anim Sci 1988; 66:1303–1313.

    PubMed  CAS  Google Scholar 

  36. Bartol FF, Wiley AA, Coleman DA et al. Ovine uterine morphogenesis: Effects of age and progestin administration and withdrawal on neonatal endometrial development and DNA synthesis. J Anim Sci 1988; 66:3000–3009.

    PubMed  CAS  Google Scholar 

  37. Taylor KM, Gray CA, Joyce MM et al. Neonatal ovine uterine development involves alterations in expression of receptors for estrogen, progesterone, and prolactin. Biol Reprod 2000; 63:1192–1204.

    Article  PubMed  CAS  Google Scholar 

  38. Taylor KM, Chen C, Gray CA et al. Expression of mRNAs for fibroblast growth factors 7 and 10, hepatocyte growth factor and insulin-like growth factors and their receptors in the neonatal ovine uterus. Biol Reprod 2001; 64:1236–1246.

    Article  PubMed  CAS  Google Scholar 

  39. Marion GB, Gier HT. Ovarian and uterine embryogenesis and morphology of the nonpregnant female mammal. J Anim Sci 1971; 32(Suppl 1):24–47.

    PubMed  Google Scholar 

  40. Gray CA, Taylor KM, Bazer FW et al. Mechanisms regulating norgestomet inhibition of endometrial gland morphogenesis in the neonatal ovine uterus. Mol Reprod Dev 2000; 57:67–78.

    Article  PubMed  CAS  Google Scholar 

  41. Guillomot M. Cellular interactions during implantation in domestic ruminants. J Reprod Fertil 1995; 49:39–51.

    CAS  Google Scholar 

  42. Hadek R, Getty R. The changing morphology in the uterus of the growing pig. Amer J Vet Res 1959; 20:573–577.

    Google Scholar 

  43. Bal HS, Getty R. Postnatal growth of the swine uterus from birth to six months. Growth 1970; 34:15–30.

    PubMed  CAS  Google Scholar 

  44. Spencer TE, Bartol FF, Wiley AA et al. Neonatal porcine endometrial development involves coordinated changes in DNA synthesis, glycosaminoglycan distribution, and 3H-glucosamine labeling. Biol Reprod 1993; 46:729–740.

    Article  Google Scholar 

  45. Tarleton BJ, Wiley AA, Spencer TE et al. Ovary-independent estrogen receptor expression in neonatal porcine endometrium. Biol Reprod 1998; 58:1009–1019.

    Article  PubMed  CAS  Google Scholar 

  46. Knight JW, Bazer FW, Thatcher WW et al. Conceptus development in intact and unilaterally hysterectomized-ovariectomized gilts: Interrelations among hormonal status, placental development, fetal fluids and fetal growth. J Anim Sci 1977; 44:620–637.

    PubMed  CAS  Google Scholar 

  47. van Rens BT, van der Lende T. Piglet and placental traits at term in relation to the estrogen receptor genotype in gilts. Theriogenology 2002; 57:1651–1667.

    Article  PubMed  Google Scholar 

  48. Brody JR, Cunha GR. Histologic, morphometric, and immunocytochemical analysis of myometrial development in rats and mice: I. Normal development. Am J Anat 1989; 186:1–20.

    Article  PubMed  CAS  Google Scholar 

  49. Branham WS, Sheehan DM, Zehr Dr et al. The postnatal ontogeny of rat uterine glands and age-related effects of 17_-estradiol. Endocrinology 1985; 117:2229–2237.

    PubMed  CAS  Google Scholar 

  50. Bartelmez GW, Corner GW, Hartman CG. Cyclic changes in the endometrium of the rhesus monkey (Macaca mulatta). Contrib Embryol. Carnegie Institut 1951; 34:99–146.

    Google Scholar 

  51. Padykula HA. Regeneration in the primate uterus: The role of stem cells. Biology of the uterus. In: Wynn RM, Jollie WP, eds. New York: Plenum Medical Book Company, 1989:279–287.

    Google Scholar 

  52. Brenner RM, Slayden OD. Cyclic changes in the primate oviduct and endometrium. In: Knobil E, Neill JD, eds. The Physiology of Reproduction. New York: Raven Press, 1994:541–569.

    Google Scholar 

  53. Bensley CM. Cyclic fluctuations in the rate of epithelial mitosis in the endometrium of the rhesus monkey. Contrib Embryol Carnegie Instit 1951; 34:89–98.

    Google Scholar 

  54. O’Rahilly R. The embryology and anatomy of the uterus. In: Norris HJ, Hertig AT, Abell MR, eds. The Uterus. Baltimore, MD: Williams and Wilkins Company, 1973:17–39.

    Google Scholar 

  55. O’Rahilly R. Prenatal human development. In: Wynn RM, Jollie WP, eds. Biology of the uterus. New York and London: Plenum Medical Book Company, 1989:35–56.

    Google Scholar 

  56. Song J. The human uterus: Morphogenesis and embryological basis for cancer. Springfield, IL: Charles C Thomas, 1964.

    Google Scholar 

  57. Valdes-Dapena MA. The development of the uterus in late fetal life, infancy, and childhood. In: Norris HJ, Hertig AT, Abell MR, eds. The Uterus. Baltimore: Williams and Wilkins Company, 1973:40–67.

    Google Scholar 

  58. Noyes RW, Hertig AT, Rock J. Dating the endometrial biopsy. Fertil Steril 1950; 1:3–25.

    Google Scholar 

  59. Wynn RM. The human endometrium: Cyclic and gestational changes. Biology of the Uterus. In: Wynn RM, Jollie WP, eds. New York: Plenum Medical Book Company, 1989:289–332.

    Google Scholar 

  60. Hisaw FL, Hisaw Jr FL. Action of estrogen and progesterone on the reproductive tract of lower primates. In: Young WC, ed. Sex and internal secretions. Baltimore: Williams and Wilkins, 1961:556–589.

    Google Scholar 

  61. Padykula HA, Coles LG, Okulicz WC et al. The basalis of the primate endometrium: A bifunctional germinal compartment. Biol Reprod 1989; 40:681–690.

    Article  PubMed  CAS  Google Scholar 

  62. Padykula HA, Coles LG, McCracken JA et al. A zonal pattern of cell proliferation and differentiation in the rhesus endometrium during the estrogen surge. Biol Reprod 1984; 31:1103–1118.

    Article  PubMed  CAS  Google Scholar 

  63. Okulicz WC, Ace CI, Scarrell R. Zonal changes in proliferation in the rhesus endometrium during the late secretory phase and menses. Proc Soc Exp Biol Med 1997; 214:132–138.

    PubMed  CAS  Google Scholar 

  64. Ma L, Yao M, Maas RL. Genetic control of uterine receptivity during implantation. Semin Reprod Endocrinol 1999; 17:205–216.

    Article  PubMed  CAS  Google Scholar 

  65. Taylor HS. The role of HOX genes in the development and function of the female reproductive tract. Semin Reprod Med 2000; 18:81–89.

    Article  PubMed  CAS  Google Scholar 

  66. Miller C, Sassoon DA. Wnt-7a maintains appropriate uterine patterning during the development of the mouse female reproductive tract. Development 1998; 125:3201–3211.

    PubMed  CAS  Google Scholar 

  67. Parr BA, McMahon AP. Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a. Nature 1998; 395:707–710.

    Article  PubMed  CAS  Google Scholar 

  68. Cunha GR. Stromal induction and specification of morphogenesis and cytodifferentiation of the epithelia of the Mullerian ducts and urogenital sinus during development of the uterus and vagina in mice. J Exp Zool 1976; 196:361–370.

    Article  PubMed  CAS  Google Scholar 

  69. Cunha GR, Chung LWK, Shannon JM et al. Hormone-induced morphogenesis and growth: Role of mesenchymal-epithelial interactions. Recent Prog Horm Res 1983; 39:559–595.

    PubMed  CAS  Google Scholar 

  70. Cunha GR, Young P, Brody JR. Role of uterine epithelium in the development of myometrial smooth muscle cells. Biol Reprod 1989; 40:861–871.

    Article  PubMed  CAS  Google Scholar 

  71. Sharpe PM, Ferguson MW. Mesenchymal influences on epithelial differentiation in developing systems. J Cell Sci Suppl 1988; 10:195–230.

    PubMed  CAS  Google Scholar 

  72. Ogasawara Y, Okamoto S, Kitamura Y et al. Proliferative pattern of uterine cells from birth to adulthood in intact, neonatally castrated and/or adrenalectomized mice, assayed by incorporation of [125I] iododeoxyruridine. Endocrinology 1983; 113:582–587.

    PubMed  CAS  Google Scholar 

  73. Cunha GR, Lung B. The importance of stroma in morphogenesis and functional activity of urogenital epithelium. In Vitro 1979; 15:50–71.

    PubMed  CAS  Google Scholar 

  74. Curry Jr TE, Osteen KG. Cyclic changes in the matrix metalloproteinase system in the ovary and uterus. Biol Reprod 2001; 64:1285–1296.

    Article  PubMed  CAS  Google Scholar 

  75. Nothnick WB. Disruption of the tissue inhibitor of metalloproteinase-1 gene results in altered reproductive cyclicity and uterine morphology in reproductive-age female mice. Biol Reprod 2000; 63:905–912.

    Article  PubMed  CAS  Google Scholar 

  76. Jost A. Studies on sex differentiation in mammals. Rec Prog Horm Res 1973; 29:1–41.

    PubMed  CAS  Google Scholar 

  77. Clark JH, Gorski J. Ontogeny of the estrogen receptor during early uterine development. Science 1970; 169:76–78.

    Article  PubMed  CAS  Google Scholar 

  78. Branham WS, Sheehan DM. Ovarian and adrenal contributions to postnatal growth and differentiation of the rat uterus. Biol Reprod 1995; 53:863–872.

    Article  PubMed  CAS  Google Scholar 

  79. Carpenter KD, Hayashi K, Spencer TE. Ovarian regulation of endometrial gland morphogenesis and activin-follistatin system in the neonatal ovine uterus. Biol Reprod 2003; 69:843–850.

    Article  PubMed  CAS  Google Scholar 

  80. Carpenter KD, Gray CA, Bryan TM et al. Estrogen and anti-estrogen effects on neonatal ovine uterine development. Biol Reprod 2003; 69:708–717.

    Article  PubMed  CAS  Google Scholar 

  81. Hayashi K, Carpenter KD, Gray CA et al. The activin-follistatin system in the neonatal ovine uterus. Biol Reprod 2003; 69:851–860.

    Article  PubMed  CAS  Google Scholar 

  82. Apter D. Serum steroids and pituitary hormones in female puberty: A partly longitudinal study. Clin Endocrinol (Oxf) 1980; 12:107–120.

    CAS  Google Scholar 

  83. Giudice LC, Chandrasekher YA, Cataldo NA. The potential roles of intraovarian peptides in normal and abnormal mechanisms of reproductive physiology. Curr Opin Obstet Gynecol 1993; 5:350–359.

    PubMed  CAS  Google Scholar 

  84. Giudice LC, Saleh W. Growth factors in reproduction. Trends Endocrinol Metab 1995; 6:60–69.

    Article  CAS  PubMed  Google Scholar 

  85. Tarleton BJ, Wiley AA, Bartol FF. Endometrial development and adenogenesis in the neonatal pig: Effects of estradiol valerate and the antiestrogen ICI 182,780. Biol Reprod 1999; 61:253–263.

    Article  PubMed  CAS  Google Scholar 

  86. Korach KS, Horigome T, Tomooka Y et al. Immunodetection of estrogen receptor in epithelial and stromal tissues of neonatal mouse uterus. Proc Natl Acad Sci USA 1988; 85:3334–3337.

    Article  PubMed  CAS  Google Scholar 

  87. Yamashita S, Newbold RR, McLachlan JA et al. Developmental pattern of estrogen receptor expression in female mouse genital tracts. Endocrinology 1989; 125:2888–2896.

    Article  PubMed  CAS  Google Scholar 

  88. Fishman RB, Branham WS, Streck RD et al. Ontogeny of estrogen receptor messenger ribonucleic acid expression in the postnatal rat uterus. Biol Reprod 1996; 55:1221–1230.

    Article  PubMed  CAS  Google Scholar 

  89. Lubahn DB, Moyer JS, Golding TS et al. Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. Proc Natl Acad Sci USA 1993; 90:11162–11166.

    Article  PubMed  CAS  Google Scholar 

  90. Sato T, Wang G, Hardy MP et al. Role of systemic and local IGF-I in the effects of estrogen on growth and epithelial proliferation of mouse uterus. Endocrinology 2002; 143:2673–2679.

    Article  PubMed  CAS  Google Scholar 

  91. Rubin JS, Bottaro DP, Chedid M et al. Keratinocyte growth factor. Cell Biol Int 1995; 19:399–411.

    Article  PubMed  CAS  Google Scholar 

  92. Bellusci S, Grindley J, Emoto H et al. Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung. Development 1997; 124:4867–4878.

    PubMed  CAS  Google Scholar 

  93. Weidner KM, Hartmann G, Sachs M et al. Properties and functions of scatter factor/hepatocyte growth factor and its receptor c-Met. Am J Respir Cell Mol Biol 1993; 8:229–237.

    PubMed  CAS  Google Scholar 

  94. Koji T, Chedid M, Rubin JS et al. Progesterone-dependent expression of keratinocyte growth factor mRNA in stromal cells of the primate endometrium: Keratinocyte growth factor as a progestomedin. J Cell Biol 1994; 125:393–401.

    Article  PubMed  CAS  Google Scholar 

  95. Siegfried S, Pekonen F, Nyman T et al. Expression of mRNA for keratinocyte growth factor and its receptor in human endometrium. Acta Obstet Gynecol Scand 1995; 74:410–414.

    PubMed  CAS  Google Scholar 

  96. Sugawara J, Fukaya T, Murakami T et al. Hepatocyte growth factor stimulate proliferation, migration, and lumen formation of human endometrial epithelial cells in vitro. Biol Reprod 1997; 57:936–942.

    Article  PubMed  CAS  Google Scholar 

  97. Baker J, Hardy MP, Zhou J et al. Effects of an Igf1 gene null mutation on mouse reproduction. Mol Endocrinol 1996; 10:903–918.

    Article  PubMed  CAS  Google Scholar 

  98. Gu Y, Branham WS, Sheehan DM et al. Tissue-specific expression of messenger ribonucleic acids for insulin-like growth factors and insulin-like growth factor-binding proteins during perinatal development of the rat uterus. Biol Reprod 1999; 60:1172–1182.

    Article  PubMed  CAS  Google Scholar 

  99. Gertler A, Djiane J. Mechanism of ruminant placental lactogen action: Molecular and in vivo studies. Mol Genet Metab 2002; 75:189–201.

    Article  PubMed  CAS  Google Scholar 

  100. Anthony RV, Limesand SW, Fanning MD et al. Placental lactogen and growth hormone: Regulation and action. In: Bazer FW, ed. The Endocrinology of Pregnancy. New Jersey: Humana Press, 1998:78:61–490.

    Google Scholar 

  101. Freeman ME, Kanyicska B, Lerant A et al. Prolactin: Structure, function, and regulation of secretion. Physiol Rev 2000; 80:1523–1631.

    PubMed  CAS  Google Scholar 

  102. Spencer TE, Bazer FW. Biology of progesterone action during pregnancy recognition and maintenance of pregnancy. Frontiers in Bioscience 2002; 7:d1879–1898.

    PubMed  CAS  Google Scholar 

  103. Horseman ND, Zhao W, Montecino-Rodriguez E et al. Defective mammopoiesis, but normal hematopoiesis, in mice with a targeted disruption of the prolactin gene. EMBO J 1997; 16:6926–6935.

    Article  PubMed  CAS  Google Scholar 

  104. Brisken C, Kaur S, Chavarria T et al. Prolactin controls mammary gland development via direct and indirect mechanisms. Dev Biol 1999; 210:96–106.

    Article  PubMed  CAS  Google Scholar 

  105. Carpenter KD, Gray CA, Noel S et al. Prolactin regulation of neonatal ovine uterine gland morphogenesis. Endocrinology 2003; 144:110–120.

    Article  PubMed  CAS  Google Scholar 

  106. Jones RL, Critchley HO, Brooks J et al. Localization and temporal expression of prolactin receptor in human endometrium. J Clin Endocrinol Metab 1998; 83:258–262.

    Article  PubMed  CAS  Google Scholar 

  107. Frasor J, Gaspar CA, Donnelly KM et al. Expression of prolactin and its receptor in the baboon uterus during the menstrual cycle and pregnancy. J Clin Endocrinol Metab 1999; 84:3344–3350.

    Article  PubMed  CAS  Google Scholar 

  108. Jabbour HN, Critchley HO. Potential roles of decidual prolactin in early pregnancy. Reproduction 2001; 121:197–205.

    Article  PubMed  CAS  Google Scholar 

  109. Spencer TE, Gray CA, Johnson GA et al. Effects of recombinant ovine interferon tau, placental lactogen, and growth hormone on the ovine uterus. Biol Reprod 1999; 61:1409–1418.

    Article  PubMed  CAS  Google Scholar 

  110. Johnson GA, Burghardt RC, Joyce MM et al. Osteopontin is synthesized by uterine glands and a 45-kDa cleavage fragment is localized at the uterine-placental interface throughout ovine pregnancy. Biol Reprod 2003; 69:92–98.

    Article  PubMed  CAS  Google Scholar 

  111. Noel S, Herman A, Johnson GA et al. Ovine placental lactogen specifically binds to endometrial glands of the ovine uterus. Biol Reprod 2003; 68:772–780.

    Article  PubMed  CAS  Google Scholar 

  112. Lacroix MC, Devinoy E, Servely JL et al. Expression of the growth hormone gene in ovine placenta: Detection and cellular localization of the protein. Endocrinology 1996; 137:4886–4892.

    Article  PubMed  CAS  Google Scholar 

  113. Srisuparp S, Strakova Z, Fazleabas AT. The role of chorionic gonadotropin (CG) in blastocyst implantation. Arch Med Res 2001; 32:627–634.

    Article  PubMed  CAS  Google Scholar 

  114. Klentzeris LD, Bulmer JN, Seppala M et al. Placental protein 14 in cycles with normal and retarded endometrial differentiation. Hum Reprod 1994; 9:394–398.

    PubMed  CAS  Google Scholar 

  115. Dockery P, Pritchard K, Warren MA et al. Changes in nuclear morphology in the human endometrial glandular epithelium in women with unexplained infertility. Hum Reprod 1996; 11:2251–2256.

    PubMed  CAS  Google Scholar 

  116. Lessey BA, Damjanovich L, Coutifaris C et al. Integrin adhesion molecules in the human endometrium: Correlation with the normal and abnormal menstrual cycle. J Clin Invest 1992; 90:188–195.

    Article  PubMed  CAS  Google Scholar 

  117. Iguchi T, Sato T. Endocrine disruption and developmental abnormalities of female reproduction. Am Zool 2000; 40:402–411.

    Article  CAS  Google Scholar 

  118. Hailing A, Forsberg JG. Acute and permanent growth effects in the mouse uterus after neonatal treatment with estrogens. Reprod Toxicol 1993; 7:137–153.

    Article  Google Scholar 

  119. Tarleton BJ, Braden TD, Wiley AA et al. Estrogen-induced disruption of neonatal porcine uterine development alters adult uterine function. Biol Reprod 2003; 68:1387–1393.

    Article  PubMed  CAS  Google Scholar 

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  1. Center for Animal Biotechnology and Genomics Department of Animal Science, Texas A&M University, College Station, Texas, USA

    Thomas E. Spencer, Karen D. Carpenter, Kanako Hayashi & Jianbo Hu

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  1. Thomas E. Spencer
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Spencer, T.E., Carpenter, K.D., Hayashi, K., Hu, J. (2005). Uterine Glands. In: Branching Morphogenesis. Molecular Biology Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-30873-3_11

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