Abstract
Propofol (2, 6-diisopropylphenol) is an intravenous anesthetic, which has been increasingly used for both the induction and maintenance of general anesthesia1, 2 as well as in critical care medicine.3 When propofol is used, one of the most important adverse effects is respiratory depression,4–8 which is caused by suppression of the central respiratory neuronal network. It is unclear, however, whether the main site of propofol action is the brainstem or the spinal cord.4–8 In most previous studies, the response of respiratory neurons to propofol has been largely neglected. We address this lacuna here.
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Kashiwagi, M., Okada, Y., Kuwana, Si., Sakuraba, S., Ochiai, R., Takeda, J. (2004). Mechanism of Propofol-Induced Central Respiratory Depression in Neonatal Rats. In: Champagnat, J., Denavit-Saubié, M., Fortin, G., Foutz, A.S., Thoby-Brisson, M. (eds) Post-Genomic Perspectives in Modeling and Control of Breathing. Advances in Experimental Medicine and Biology, vol 551. Springer, Boston, MA. https://doi.org/10.1007/0-387-27023-X_34
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DOI: https://doi.org/10.1007/0-387-27023-X_34
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