Identification and characterization of stromal-like cells with CD207+/low CD1a+/low phenotype derived from histiocytic lesions – a perspective in vitro model for drug testing
Authors (first, second and last of 10)
Collection
Advances in pre-clinical cancer models
Cancer models are indispensable research tools, as they help elucidating the mechanisms involved in tumour onset and progression, leading to the development of new therapeutic treatments. While widely-used conventional two-dimensional cell models have been the gold standard for many decades, some of their main limitations include the lack of representation of the stromal population, the absence of a three-dimensional structure, and a poor representation of inter-tumour and intra-tumour heterogeneity. Therefore, a multitude of novel cancer models are emerging, which can advance the understanding of tumour pathophysiology and behavior. This will ultimately help improving patients’ clinical outcomes, through the introduction of more personalized and targeted treatments in the clinical setting.
In recognition of the growing field of research, BMC Cancer welcomes submissions to a newly launched collection ‘Advances in pre-clinical cancer models’. Topics of interest for this special issue include but are not limited to:
- Scaffold-based in vitro models
- 3D cell cultures
- Co-culture settings
- Tumour organoids
- Large and small animal models
- Genetically engineered cell lines and animal models
- Chemically induced tumour models
- Xenotransplantation models (Patient derived xenografts, cell-line derived xenograft)
- Allotransplantation models
Articles (9 in this collection)
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Magnetic resonance imaging-guided intracranial resection of glioblastoma tumors in patient-derived orthotopic xenografts leads to clinically relevant tumor recurrence
Authors (first, second and last of 5)
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A novel patient-derived immortalised cell line of myxofibrosarcoma: a tool for preclinical drugs testing and the generation of near-patient models
Authors (first, second and last of 16)
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Hepatocyte-specific HDAC3 ablation promotes hepatocellular carcinoma in females by suppressing Foxa1/2
Authors (first, second and last of 12)
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Impact of media compositions and culture systems on the immunophenotypes of patient-derived breast cancer cells
Authors (first, second and last of 12)
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Novel human lymph node-derived matrix supports the adhesion of metastatic oral carcinoma cells
Authors (first, second and last of 16)
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Patient-derived organoids for precision oncology: a platform to facilitate clinical decision making
Authors (first, second and last of 4)
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Analysis of connexin 43, connexin 45 and N-cadherin in the human sertoli cell line FS1 and the human seminoma-like cell line TCam-2 in comparison with human testicular biopsies
Authors (first, second and last of 15)
