Extracellular vesicles

Extracellular vesicles (EVs) are a heterogeneous group of cell-derived vesicles mediating the intercellular crosstalk. These vesicles carry the bioactive cargo from the donor cells, such as nucleic acids, proteins, lipids, and metabolites, and transfer it to the recipient cells both locally and remotely, causing a change in their behavior. The release and composition of EVs is altered under pathological conditions, which can have a significant impact on the pathobiological processes. EVs can help in the adaptation of cells to the harsh environmental conditions as well as facilitate the remodeling of stroma. Researchers are unveiling the functions of EVs at a rapid pace in reproductive process, stem cell biology, and malignancy. A role of EVs in immune modulation and therapeutic resistance is also being investigated. Further, being a natural carrier of biomolecules and their easy modifiability to enhance cell-specific targeting and cellular uptake, EVs represent a useful candidate for the development of efficient drug delivery systems. EVs are also a useful resource for biomarker development to assist in disease diagnosis, predicting the disease status, and monitoring of the therapeutic responses. In this collection, we welcome original research articles, review manuscripts, as well as short communications that highlight the role of EVs in ovarian biology and pathobiology, targeting of their biogenesis and functions for therapeutic gain, and their potential utility in biomarker development and as drug delivery systems.

Articles (8 in this collection)