The platelet derived non-coding RNAs and thrombosis: from bench to bed

Platelet is enriched with non-coding RNAs, including microRNAs, circular RNAs, long non-coding RNAs, YRNAs and exogenous plant non-coding RNAs. Non-coding RNAs of platelets have been explored in the mechanisms of megakaryocytic differentiation, platelet formation, vascular homeostasis, and inflammation. An accumulating body of evidence suggests that quantitative differences in the relative abundance of non-coding RNAs contribute to susceptibility to, and prog-nosis of, human thrombotic diseases. However, important questions upon non-coding RNAs of platelet remain unanswered, including the specific function in acute and chronic thrombotic diseases, the interaction with the signaling pathway of platelet activation, the role in transcription and translation, and the physiological relevance of transferring into and out of platelets. Moreover, it remains to be seen whether platelet reactivity signatures based on non-coding RNAs measurements can address the clinical need or improve risk management of thrombotic complications. Therefore, studies on the Non-coding RNAs of platelet are greatly needed for the enlightening the potential mechanisms behind thrombosis and the practical value for clinical application.