Collection

Multiphysics Simulation in Drug Development and Delivery

In recent years, multiphysics simulation as an emerging technology has revolutionised drug development remarkably. From microscale to macroscale, a wide spectrum of models have been applied to mimic human in vivo environment and predict drug behaviours. Depending on the specific delivery process, these models are developed by combining different principles; these may include pharmacokinetics, pharmacodynamics, fluid mechanics, tissue mechanics, mass transport, heat transfer and biochemical reaction, etc. As a consequence, multiphysics simulation allows to integrate information from different stages in drug development, examine multiple interlinked delivery processes individually or in an integrated manner, and identify opportunities for maximising delivery outcomes and treatment efficacy. This can not only reveal the mechanisms of drug delivery, but also provide significant impacts on the determination of guidelines for drug development. Considering its promising performance, multiphysics simulation is now of tremendous interest. Overall, this theme issue is commissioned to capture the state-of-art research efforts on multiphysics simulation in the areas of drug development and drug delivery, and to show their potential impact on clinical care. The knowledge gained in this Pharmaceutical Research special issue falls into multiple categories, including model development for exploring delivery mechanism and drug behaviour, applications in examining in vivo environment and its effects, and outcomes of deliveries using various plain drugs, drug delivery systems and delivery methods. Browse journal articles below!

Editors

  • Wenbo Zhan

    Wenbo Zhan is a Lecturer in Biological Engineering in the School of Engineering. He received his undergraduate degrees from Xi’an Jiatong University in 2008 and a master degree from Harbin Institute of Technology in 2010. He graduated from Imperial College London with his PhD degree in 2014 and then worked as a project consultant at Imperial College London and a postdoctoral research fellow at the National University of Singapore until 2016. Prior to joining the University of Aberdeen in 2019, he was a research associate at Imperial College London.

  • Chi-Hwa Wang

    Dr Chi-Hwa Wang is a Professor of Chemical and Biomolecular Engineering at the National University of Singapore (NUS). He received his B.S. degree (Chemical Engineering) from the National Taiwan University, M.S. degree (Biomedical Engineering) from Johns Hopkins University, M.A. and PhD degrees (both in Chemical Engineering) from Princeton University, respectively. His research interests include drug delivery system and particle technology. Chi-Hwa is the recipient of AIChE Shell Thomas Baron Award 2018, AIChE Fellow 2019, and WSSET Fellow 2020.

Articles (10 in this collection)