Collection
Bioorthogonal reactions: advances and applications in chemical biology and biomedicine
This topical collection will cover recent advances (since 2016) in the development and use of bioorthogonal reactions. The individual chapters will cover the most important aspects and developments in the field and will be written by leading experts. We believe that the awarding of the Nobel Prize in Chemistry last year for the development of click and bioorthogonal chemistry, together with the first clinical trials utilizing bioorthogonal reactions ongoing, makes this the perfect timing for publishing a collection of this type. The collection will aim not only at experts in the field, but also at researchers from different fields who exploit the tools and approaches of bioorthogonal chemistry. In addition, we aim to evoke interest among students and next-generation scientists to join and work in this emerging area.
Editors
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Dr. Milan Vrábel
Milan Vrábel’s (head of Chemistry of Bioconjugates group at IOCB/ Prague) interests include the study and development of various bioorthogonal click reactions to image and modulate various biological systems. The focus lies at the interface between chemistry and biology focusing on using chemical tools to advance our understanding of biology and transferring the knowledge into real applications. Milan worked on the development of new tools enabling, the labeling and study of various bioconjugates. This work led to the development of an efficient methodology for chemical re-engineering of cell surfaces and modulation of their properties.
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Dr. Hannes Mikula
Inspired by the emerging field of bioorthogonal chemistry, Hannes Mikula started working on the investigation and development of click-triggered bond-cleavage reactions. Hannes’ team is now mainly focusing on the design of next level bioorthogonal tools and reactions for diagnostic and therapeutic applications and the development of bioorthogonal strategies to navigate molecules in cellular environments.
