Treatment-resistant psychiatric disorders

BMC Psychiatry welcomes submissions to our Collection on Treatment-resistant psychiatric disorders. Treatment-resistant psychiatric disorders present a significant challenge in mental health care, as individuals with these conditions often do not respond to standard treatments, including medication and psychotherapy. This Collection gathers research on the complexities of treatment-resistant mental illnesses such as depression, anxiety, bipolar disorder, schizophrenia, and co-occurring conditions. We invite submissions that investigate the underlying mechanisms of treatment resistance as well as the impact of misdiagnosis, medication intolerance, and patient incompliance in the context of treatment-resistant psychiatric disorders. It is important for us to continue advancing our collective understanding of treatment-resistant psychiatric disorders to improve patient outcomes and quality of life. Recent advances in this area have highlighted the need for personalized treatment approaches, considering individual variations in treatment response and the presence of co-occurring conditions. Additionally, research has emphasized the importance of addressing the underlying neurobiological mechanisms of treatment resistance and exploring innovative therapeutic modalities beyond traditional medication and therapy. Topics of interest include, but are not limited to: - Mechanisms of treatment resistance in psychiatric disorders - Personalized treatment approaches for treatment-resistant mental illnesses - Innovative therapeutic modalities for treatment-resistant psychiatric disorders - Mechanisms of treatment resistance in specific psychiatric disorders (e.g., depression, anxiety, bipolar disorder, schizophrenia) - Impact of misdiagnosis and co-occurring conditions on treatment resistance - Innovative therapeutic modalities such as neuromodulation and digital interventions for treatment-resistant psychiatric disorders - Challenges associated with lack of patient compliance and strategies to improve adherence to treatment regimens This Collection supports and amplifies research related to SDG 3: Good Health and Wellbeing.