Collection

Immune response to Influenza virus and vaccine in old adults

Submission status
Closed
Seasonal influenza is a common respiratory infection that causes significant health burden worldwide, particularly in older adults. Studies of altered immune functions with aging in human and animal model systems have identified underlying mechanisms and offer potential therapeutic insights. Vaccination is an effective tool to reduce and even prevent severe infection and its complications. Recent improvements in vaccine design enhance vaccine efficacy for at-risk older adults. Understanding innate, humoral and cellular conditions of the host immune system that contribute to severe infection and to age-associated alterations in vaccine response represent important steps in reducing the disease burden of influenza for the growing older adult population. This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process. Please find out more about our journal and its policies, here. Submission guidelines can be found here, and please submit to the series via our submission system (there will be a field for which you can indicate if you are submitting to this series).

Editors

  • Sean X. Leng, MD, PhD Sean X. Leng, MD, PhD  &

    Sean X. Leng, MD, PhD

    Sean X. Leng, MD, PhD, is a board-certified geriatrician and Paul Beeson scholar, Professor of Medicine, Molecular Microbiology and Immunology at Johns Hopkins University School of Medicine and Johns Hopkins Bloomberg School of Public Health. His translational aging research covers frailty, causes and consequences of age-related immune functional decline with a particular focus on influenza immunization in older adults. More recently, Dr. Leng has established and directs Johns Hopkins Center on Aging and Immune Remodeling (JH CAIR).

  • Albert Shaw, MD, PhD Albert Shaw, MD, PhD

    Albert Shaw, MD, PhD

    Albert Shaw, MD, PhD, is Professor of Medicine in the Section of Infectious Diseases at the Yale School of Medicine. His laboratory has a longstanding focus on the immunology of aging, with a special interest in age-associated innate immune dysregulation and the effects of aging on signatures of influenza vaccine response. Dr. Shaw is a member of the Editorial Board for Immunity & Ageing.

Articles (8 in this collection)