“Flexible hinge” dynamics in mismatched DNA revealed by fluorescence correlation spectroscopy
Authors (first, second and last of 5)
Collection
The Revolutionary Impact of Landscapes in Biology
Darwin in his epochal Origin of the Species famously referred to life as a "tangled bank“ of great complexity, unified by the process of natural selection. Physicists too have always sought simplifying ideas of great power capable of making complex phenomena comprehensible and quantitative. A unifying idea in physics that ties together many complex phenomena in biology is the concept of a landscape, broadly defined. This idea not only encompasses the idea of the free energy landscape of a folding protein, but extends out to concepts in neurobiology, immunology, evolution, ecology and the emergence of (and resistance to) disease. We have not found in the literature a coherent collection of articles which use the central idea of landscapes defined in this most broad sense. We propose a collection of articles bringing together work at the cutting edge of biological physics that illustrates how the concept of dynamics on landscapes provides a unifying framework for some of the most urgent problems in current interdisciplinary science.
Editors
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Robert Austin
Princeton University, USA
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Shyamsunder Erramilli
Boston University, USA
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Sonya Bahar
University of Missouri at St. Louis, USA
Articles (13 in this collection)
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Thermodynamics of unfolding mechanisms of mouse mammary tumor virus pseudoknot from a coarse-grained loop-entropy model
Authors (first, second and last of 5)
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Exploring the folding energy landscapes of heme proteins using a hybrid AWSEM-heme model
Authors (first, second and last of 5)
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Learning the local landscape of protein structures with convolutional neural networks
Authors (first, second and last of 5)
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