Collection
Most Popular Articles Published in Histochemistry and Cell Biology in 2020
In this Collection, we feature the most popular papers published in Histochemistry and Cell Biology in 2020 – those whose PDFs were downloaded more than 1,000 times in the two years following their publication. These highly-downloaded articles account for 38% of the publications in 2020, with an additional 31% downloaded between 500 and 999 times.
The most popular 2020 publication was “Zebrafish cardiac regeneration—looking beyond cardiomyocytes to a complex microenvironment” (Ryan, Moyse and Richardson) with over 4,396 downloads. This was a contribution to HCB’s Special Issue on "In Vivo Cell Biology in Zebrafish - New Insights Into Vertebrate Development and Disease" edited by Scholpp and Schrader ("Introduction: in vivo cell biology in zebrafish"). This Special Issue covered various aspects of zebrafish biology, including state-of-the-art reagents, tools and methods used to probe actin biology and functions in zebrafish embryo and larvae, the importance of protocadherin 18a for prechordal plate formation, the application of fluorescence correlation spectroscopy to study the dynamics of biomolecules within the living zebrafish, and of light sheet microscopy to asses lipid storage in drug and morpholino-induced Nieman-Pick type C disease and Smith-Lemli-Opitz syndrome. Furthermore, the potential of zebrafish as a model to study heart regeneration following cardiac injury, to characterize MicroRNA profiles in mechanically mediated joint degeneration, to study autophagy in the context of skeletal development and disease, to analyse the pathophysiology of skin injury due to exposure to short-wavelength visible light spectrums, and the toxic effects of environmental silver pollution during development were reviewed.
The next most popular articles published in 2020 were “Detection of doxorubicin, cisplatin and therapeutic antibodies in formalin-fixed paraffin-embedded human cancer cells” by Böckelmann et al. and “Different localization of lysosomal-associated membrane protein 1 (LAMP1) in mammalian cultured cell lines” by Baba et al. with 3,382 and 3,358 downloads, respectively.
With similar numbers of downloads and of comparable significance and interest, the Editors would like to mention "Zebrafish as a model to study autophagy and its role in skeletal development and disease" by Moss et al. and "Neodymium as an alternative contrast for uranium in electron microscopy" by Kuipers and Giepmans.
Further notable and highly read papers reported diverse methodical advancements such as the the detection of intramuscular triglyceride on a fiber type- and subcellular-specific basis, the combination of enhanced expansion microscopy combined with machine learning for the precise, rapid and inexpensive diagnostic pathology, and a comparison of a prototype immunohistochemical detection technology (PIDT) by Agilent Technologies with their well-established EnVision FLEX visualization system. Additional top-downloaded papers encompass topics ranging from the influence of human galectin-3 design on its lectin activity, the location, phenotype and proliferation of plasma cells in human palatine tonsils, as well as transcriptomic gene expression analysis of ovarian granulosa cells, a microarray gene expression analysis of immature and in vitro matured porcine oocytes, and the contribution of the tricellular tight junction protein LSR/angulin-1 to the epithelial barrier and malignancy in human pancreatic cancer cells in vitro.
The papers featured in this Collection cover the broad field of Histochemistry and of Cell Biology, as well as of Developmental Biology, basic and applied bio-medical research and diagnostic pathology. We congratulate all featured authors on achieving this popularity and hope that readers like yourself enjoy discovering their brilliant work.
The Collection is presented in chronological order.
Editors
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Jürgen Roth
Senior Editor-in-Chief of Histochemistry and Cell Biology and emeritus Professor of Cell and Molecular Pathology, University of Zurich, Switzerland.
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Douglas Taatjes
Editor-in-Chief (The Americas) of Histochemistry and Cell Biology, Professor of Pathology and Laboratory Medicine; Director, Microscopy Imaging Center; Director, Center for Biomedical Shared Resources, University of Vermont, USA
Articles (33 in this collection)
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Developmental exposure window influences silver toxicity but does not affect the susceptibility to subsequent exposures in zebrafish embryos
Authors (first, second and last of 4)
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Visualisation of cholesterol and ganglioside GM1 in zebrafish models of Niemann–Pick type C disease and Smith–Lemli–Opitz syndrome using light sheet microscopy
Authors (first, second and last of 9)
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The role of EP-2 receptor expression in cervical intraepithelial neoplasia
Authors (first, second and last of 10)
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Critical assessment of staining properties of a new visualization technology: a novel, rapid and powerful immunohistochemical detection approach
Authors (first, second and last of 6)
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Spatio-temporal distribution of tubulin-binding cofactors and posttranslational modifications of tubulin in the cochlea of mice
Authors (first, second and last of 5)
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Divergence exists in the subcellular distribution of intramuscular triglyceride in human skeletal muscle dependent on the choice of lipid dye
Authors (first, second and last of 5)
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Cytoplasmic VDR expression as an independent risk factor for ovarian cancer
Authors (first, second and last of 13)
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CREB activity is required for mTORC1 signaling-induced primordial follicle activation in mice
Authors (first, second and last of 8)
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Pcdh18a regulates endocytosis of E-cadherin during axial mesoderm development in zebrafish
Authors (first, second and last of 12)
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Developmental patterns in human blood–brain barrier and blood–cerebrospinal fluid barrier ABC drug transporter expression
Authors (first, second and last of 9)
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Sirtuin1 expression and survival in endometrial and clear-cell uterine cancer
Authors (first, second and last of 14)
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Protein expression pattern of the molecular chaperone Mdg1/ERdj4 during embryonic development
Authors (first, second and last of 5)
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Influence of protein (human galectin-3) design on aspects of lectin activity
Authors (first, second and last of 13)
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Genes regulating hormone stimulus and response to protein signaling revealed differential expression pattern during porcine oocyte in vitro maturation, confirmed by lipid concentration
Authors (first, second and last of 18)
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Plasma cells, plasmablasts, and AID+/CD30+ B lymphoblasts inside and outside germinal centres: details of the basal light zone and the outer zone in human palatine tonsils
Authors (first, second and last of 5)
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Cellular organization and histogenesis of adenosquamous carcinoma of the pancreas: evidence supporting the squamous metaplasia concept
Authors (first, second and last of 12)
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Significance of achaete-scute complex homologue 1 (ASCL1) in pulmonary neuroendocrine carcinomas; RNA sequence analyses using small cell lung cancer cells and Ascl1-induced pulmonary neuroendocrine carcinoma cells
Authors (first, second and last of 9)
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Photochemistry of nitric oxide and S-nitrosothiols in human skin
Authors (first, second and last of 4)
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Transcriptomic analysis of expression of genes regulating cell cycle progression in porcine ovarian granulosa cells during short-term in vitro primary culture
Authors (first, second and last of 15)
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Detection of doxorubicin, cisplatin and therapeutic antibodies in formalin-fixed paraffin-embedded human cancer cells
Authors (first, second and last of 9)
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Different localization of lysosomal-associated membrane protein 1 (LAMP1) in mammalian cultured cell lines
Authors (first, second and last of 10)
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Aging results in accumulation of M1 and M2 hepatic macrophages and a differential response to gadolinium chloride
Authors (first, second and last of 4)
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Tricellular tight junction protein LSR/angulin-1 contributes to the epithelial barrier and malignancy in human pancreatic cancer cell line
Authors (first, second and last of 12)
