Maintenance of genome integrity under physical constraints

Mechanical forces and structural constraints can have a pronounced effect on nuclear organization, and ultimately cell function. In this special issue, we will highlight the range of physical constraints that act on and affect the nucleus, from three-dimensional chromatin organization, to nuclear compartmentalization through phase separation to the mechanical deformation of nuclei. Reviews will highlight how these events affect DNA transactions from the response to DNA damage to DNA replication to the epigenetic control of gene expression. Physical constraints can have a direct impact on genome fragility and DNA repair, cell identity and fitness. Understanding their impact and consequences is thus expected to have immediate bearing on our understanding of normal physiology and disease, particularly malignancy and metastasis.


  • Philipp Oberdoerffer

    Philipp Oberdoerffer is an Associate Professor of Radiation Oncology and Molecular Radiation Sciences at the Johns Hopkins School of Medicine. His laboratory investigates how the epigenetic control of genome maintenance determines the cellular response to DNA damage, and ultimately malignant transformation. Philipp received his Ph. D. in mouse genetics and immunology from the University of Cologne, Germany, and went on to pursue studies on the molecular biology of aging as a postdoc at Harvard Medical School.

  • Evi Soutoglou

    Evi Soutoglou is a Research Professor at the Genome Damage and Stability Centre of Sussex University. Her lab is interested in how chromatin and nuclear structure affects DNA repair processes and has used CRSIP/Cas9 targeting and other tools for studying DSBs at specific chromatin contexts. Evi Soutoglou received her PhD from the University of Crete, Greece and she was trained in tissue-specific gene regulation. As a post-doc at the National Cancer Institute (NCI) at NIH, she focused her attention to the emerging role of chromatin structure in DNA repair. Her work provided new insights into the cellular properties of DSBs.


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