Collection
Translational Pharmacokinetics and Pharmacodynamics in CNS and Beyond
This special issue, entitled "Translational Pharmacokinetics and Pharmacodynamics in CNS and beyond" is dedicated to Emerita Professor Margareta Hammarlund-Udenaes, former Dean of the Faculty of Pharmacy and Head of the Translational Pharmacokinetics/ Pharmacodynamics Department at Uppsala University, Sweden. Professor Hammarlund-Udenaes contributed significantly to understanding of brain pharmacokinetics of drugs and published several influential papers in Pharmaceutical Research. Considering her professional interests as well as the impact of her research and teaching, this issue dedicated to Margareta Hammarlund-Udenaes covers a broad scientific scope in the areas of translational pharmacokinetics/ pharmacodynamics (PK/PD), experimental PK, clinical PK, CNS drug delivery of small and large molecules, CNS microdialysis for investigation of drug PK/PD, nanotechnologies in CNS drug delivery, pharmacokinetic modelling of CNS drug exposure, preclinical CNS drug development, intracellular drug exposure, novel methods for investigation of blood-brain barrier transport of drugs and intra-CNS distribution in health and disease. Browse journal articles below!
Editors
-
Elizabeth CM de Lange
Elizabeth CM de Lange, PhD, FAAPS, PharmDhc, is Professor in Predictive Pharmacology, Research Division of Systems Biomedicine and Pharmacology, LACDR, at Leiden University, Leiden, the Netherlands.
-
David E. Smith
David E. Smith, PhD, FAAPS, FAAAS, is the John G. Wagner Collegiate Professor of Pharmaceutical Sciences at the University of Michigan, College of Pharmacy, Ann Arbor, Michigan, USA.
-
Tetsuya Terasaki
Tetsuya Terasaki, Ph.D., is a Research Director at the University of Eastern Finland, School of Pharmacy, Kuopio, Finland and Emeritus Professor of Tohoku University, Japan.
-
Irena Loryan
Irena Loryan, MD, PhD, is an Associate Professor in the Department of Pharmacy, Uppsala University, Sweden.
Articles (28 in this collection)
-
-
Professor Margareta Hammarlund-Udenaes - Humbled Scientist Shaping Modern Neuropharmacokinetics
Authors (first, second and last of 9)
-
Pharmacokinetics and Pharmacodynamic Effect of a Blood-Brain Barrier-Crossing Fusion Protein Therapeutic for Alzheimer’s Disease in Rat and Dog
Authors (first, second and last of 11)
-
Drug Distribution in Brain and Cerebrospinal Fluids in Relation to IC50 Values in Aging and Alzheimer’s Disease, Using the Physiologically Based LeiCNS-PK3.0 Model
Authors (first, second and last of 4)
-
Shedding Light on the Blood–Brain Barrier Transport with Two-Photon Microscopy In Vivo
Authors (first, second and last of 5)
-
Transferrin Receptor Binding BBB-Shuttle Facilitates Brain Delivery of Anti-Aβ-Affibodies
Authors (first, second and last of 6)
-
-
-
Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain—a Game Changing Parameter for CNS Drug Discovery and Development
Authors (first, second and last of 18)
-
Construction and Functional Evaluation of a Three-Dimensional Blood–Brain Barrier Model Equipped With Human Induced Pluripotent Stem Cell-Derived Brain Microvascular Endothelial Cells
Authors (first, second and last of 9)
-
-
-
-
Characterization of Aripiprazole Uptake Transporter in the Blood-Brain Barrier Model hCMEC/D3 Cells by Targeted siRNA Screening
Authors (first, second and last of 7)
-
-
In Vitro-In Vivo Correlation of Blood–Brain Barrier Permeability of Drugs: A Feasibility Study Towards Development of Prediction Methods for Brain Drug Concentration in Humans
Authors (first, second and last of 9)
-
Pharmacoproteomics of Brain Barrier Transporters and Substrate Design for the Brain Targeted Drug Delivery
Authors (first, second and last of 5)
-
-
-
In-Vivo and Ex-Vivo Brain Uptake Studies of Peptidomimetic Neurolysin Activators in Healthy and Stroke Animals
Authors (first, second and last of 12)
-
Population Pharmacokinetics of Flucloxacillin In Bone and Soft Tissue– Standard Dosing is Not Sufficient to Achieve Therapeutic Concentrations
Authors (first, second and last of 9)
-
Antibody-Targeted Liposomes for Enhanced Targeting of the Blood-Brain Barrier
Authors (first, second and last of 5)
-
A Semi-Physiological Three-Compartment Model Describes Brain Uptake Clearance and Efflux of Sucrose and Mannitol after IV Injection in Awake Mice
Authors (first, second and last of 10)
-
-
Differences in Cerebral Distribution between Imipramine and Paroxetine via Membrane Transporters at the Rat Blood-Brain Barrier
Authors (first, second and last of 5)
-
High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3, OCT3
Authors (first, second and last of 8)
-
Limited Impact of Murine Placental MDR1 on Fetal Exposure of Certain Drugs Explained by Bypass Transfer Between Adjacent Syncytiotrophoblast Layers
Authors (first, second and last of 10)
-
Effect of Insulin Receptor-Knockdown on the Expression Levels of Blood–Brain Barrier Functional Proteins in Human Brain Microvascular Endothelial Cells
Authors (first, second and last of 4)
