Modern Poisons pp 113-122 | Cite as

Low-Dose Chemical Carcinogenesis



At the same time that Frances Kelsey was acting as a human firewall, protecting the United States from the emerging European thalidomide tragedy, the United States was also struggling with the issue of how to regulate the use of chemical food additives. For the first half of the century, very few functional ingredients were added to food. After World War II, however, there was a revolution in food processing that rivaled the revolution that was occurring in the pharmaceutical and pesticide industries. The American way of life was becoming more urbanized, and there was public demand for foods that were of uniform quality, safety, and convenience. This demand, coupled with new scientific developments, led to a highly diverse supply of processed food, and led also to the use of a considerable number of food additives.


Bladder Cancer Food Additive Steroid Receptor Artificial Sweetener Carcinogenic Compound 
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  1. Asch, P. “Food Safety Regulation: Is the Delaney Clause the Problem or Symptom?” Policy Sciences 23 (1990): 97–110.CrossRefGoogle Scholar
  2. Baker, M. “Insights from the Structure of Estrogen Receptor into the Evolution of Estrogens: Implications for Endocrine Disruption.” Biochemical Pharmacology 82 (2011): 1–8.CrossRefGoogle Scholar
  3. Blair, R. M., H. Fang, W. S. Branham, B. S. Hass, S. L. Dial, C. L. Moland, W. Tong, L. Shi, R. Perkins, and D. M. Sheehan. “The Estrogen Receptor Binding Affinities of 188 Natural and Xenochemicals: Structural Diversity of Ligands.” Toxicological Sciences 54 (2000): 138–53.CrossRefGoogle Scholar
  4. Creton, S., M. J. Aardema, P. L. Carmichael, J. S. Harvey, F. L. Martin, R. F. Newbold, M. R. O’Donovan, et al. “Cell Transformation Assays for Prediction of Carcinogenic Potential: State of the Science and Future Research Needs.” Mutagenesis 27, no. 1 (Jan 2012): 93–101. doi:10.1093/mutage/ger053.CrossRefGoogle Scholar
  5. Fagan, D. “The Learning Curve.” Nature 490 (25 October 2012): 462–65.CrossRefGoogle Scholar
  6. Junod, S. W. “Sugar: A Cautionary Tale.” US Food and Drug Administration, 2003., accessed January 1, 2016.Google Scholar
  7. Levenson, A. S., and V. C. Jordan. “The First Hormone-Responsive Breast Cancer Cell Line.” Cancer Research 57 (1997): 3071–78.Google Scholar
  8. Melnick, R., G. Lucier, M. Wolfe, R. Hall, G. Stancel, G. Prins, M. Gallo, et al. “Summary of the National Toxicology Program’s Report of the Endocrine Disruptors Low-Dose Peer Review.” Environmental Health Perspectives 110 (2002): 427–31.CrossRefGoogle Scholar
  9. Vandenberg, L. N., T. Colborn, T. B. Hayes, J. J. Heindel, D. R. Jacobs Jr., D.-H. Lee, T. Shioda, et al. “Hormones and Endocrine-Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose Responses.” Endocrine Reviews 33 (2012): 1–78.CrossRefGoogle Scholar
  10. Welshons, W. V., K. A. Thayer, B. M. Judy, J. A. Taylor, E. M. Curran, and F. S. vom Saal. “Large Effects from Small Exposures: I. Mechanisms for Endocrine-Disrupting Chemicals with Estrogenic Activity.” Environmental Health Perspectives 111 (2003): 994–1006.CrossRefGoogle Scholar
  11. Yager, J. D., and N. E. Davidson. “Estrogen Carcinogenesis in Breast Cancer.” New England Journal of Medicine 354 (2006): 270–82.CrossRefGoogle Scholar

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© Alan Kolok 2016

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