Abstract
Mycotoxins are secondary fungal metabolites that can cause pathological, physiological, and/or biochemical alterations in other species, including higher vertebrates. Zearalenone (ZEN) is produced by the genus Fusarium and after ingestion via contaminated cereals, may lead to animal fertility problems and reproductive pathologies. The compound has endocrine disrupting effects with a strong estrogenic action. Current data indicates that pig (hyperestrogenism) is amongst the most susceptible to ZEN, whilst in humans, this mycotoxin is suspected to be a triggering factor for central precocious puberty development in girls. Biotransformation of ZEN forms the metabolites α-zearalenol (α-ZOL) and β-zearalenol (β-ZOL), which are also produced by Fusarium in cultures, but in lower concentrations than ZEN.
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References
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Busk, Ø.L. et al. (2012). Changes in the proteome of the H295R steroidogenesis model associated with exposure to the mycotoxin zearalenone and its metabolites, α- and β-zearalenol. In: Rodrigues, P., Eckersall, D., de Almeida, A. (eds) Farm animal proteomics. Wageningen Academic Publishers. https://doi.org/10.3920/978-90-8686-751-6_12
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DOI: https://doi.org/10.3920/978-90-8686-751-6_12
Publisher Name: Wageningen Academic Publishers
Online ISBN: 978-90-8686-751-6
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