Effect of Staphylococcus aureus infection on fibrinogen and plasma protein concentrations in experimentally obese rabbits

  • E. Dishlyanova
  • T. M. Geoggieva
  • T. Vlaykova
  • I. Penchev Georgiev
Conference paper

Abstract

The acute phase response to inflammation or infection is encountered in almost all animal species, but the response of individual proteins is species-specific. Kushner et al. (Kushner et al., 2006) classify positive acute phase proteins (APP) into 3 groups: (1) APP whose concentration increased by 50 % (ceruloplasmin and С3); (2) APP exhibiting 2- to 3-fold increase (haptoglobin, fibrinogen and α-albumin with antiprotease activity) and 3) proteins, increasing extremely rapidly up to 1000 times (C-reactive protein and SAA). In fact, 98 % of protein content of blood plasma (serum) consists of 22 proteins, and the rest 2 % comprise about 1000, which could serve as biomarkers (Stanley and Van Eyk, 2005). The changes in plasma proteins concentrations are often utilised for diagnostic purposes (Andonova, 2002; Marshall, 1994).

Keywords

Post Infection Acute Phase Protein Acute Phase Response Staphylococcal Infection Fibrinogen Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

References

  1. Alsemgeest, S.P.M., 1994. Blood concentration of acute phase proteins in cattle as markers for disease, Utrecht university, the Nederland, Utrecht.Google Scholar
  2. Andonova, M., 2002. Role of innate defence mechanisms in acute phase response against gram-negative agents. Bulg. J. Vet. Med. 5: 77-92.Google Scholar
  3. Devriese, L.A., Godard, C., Okerman, L. and Renault, L., 1981. Characteristics of Staphylococcus aureus strains from rabbits. Ann Rech Vet 12: 327-332.PubMedGoogle Scholar
  4. Devriese, L.A., Hendrickx, W., Godard, C., Okerman, L. and Haesebrouck, F., 1996. A new pathogenic Staphylococcus aureus type in commercial rabbits. Zentralbl Veterinarmed B 43: 313-315.PubMedGoogle Scholar
  5. Eckersall, P.D., 2000. Acute phase proteins as markers of infection and inflammation; monitoring animal health, animal welfare and food safety. Irish Vet.J 53: 307-311.Google Scholar
  6. Kolb, V.G. and Kamishnikov, V.S., 1982. Practical book in clinical chemistry, 2nd ed, Belarus, pp. 31-33.Google Scholar
  7. Kushner, I., Rzewnicki, D. and Samols, D., 2006. What does minor elevation of C-reactive protein signify? Am J Med 119: e17-28.PubMedCrossRefGoogle Scholar
  8. Marshall, W., 1994. Plasma proteins. In: W. Marshall (Ed.), An illustrated textbook of clinical chemistry, 2nd ed. Mosby, Mosby-Year Bool Europe Limited, London, UK, pp. 210-221.Google Scholar
  9. Stanley, B. and Van Eyk, J.E., 2005. Clinical proteomics and technologies to define and diagnose heart disease. Walsh. Mech. Cardio 7: 651-665.Google Scholar
  10. Todorov, J., 1972. Nephelimetric determination of fibrinogen (method of Podmore), Clinical Laboratory Technics. Medizina and Fizkultura,, Sofia, pp. 250.Google Scholar
  11. Wills, Q.F., Kerrigan, C. and Soothill, J.S., 2005. Experimental bacteriophage protection against Staphylococcus aureus abscesses in a rabbit model. Antimicrob Agents Chemother 49: 1220-1221.PubMedCentralPubMedCrossRefGoogle Scholar

Copyright information

© Wageningen Academic Publishers 2013

Authors and Affiliations

  • E. Dishlyanova
    • 1
  • T. M. Geoggieva
    • 1
  • T. Vlaykova
    • 1
  • I. Penchev Georgiev
    • 2
  1. 1.Faculty of Veterinary MedicineTrakia UniversityStara ZagoraBulgaria
  2. 2.Faculty of MedicineTrakia UniversityStara ZagoraBulgaria

Personalised recommendations