Community Experience With Intravenous Thrombolysis for Acute Stroke

  • Lama Al-Khoury
  • Christy M. Jackson
Part of the Current Clinical Neurology book series (CCNEU)


The US Food and Drug Administration (FDA) approved intravenous tissue plasminogen activator (t-PA) as treatment for acute ischemic stroke in June 1996, based on the results of the National Institute of Neurological Disorders and Stroke (NINDS) study (see  Chapter 7). The next important question was whether t-PA treatment could be applied in nonstudy community medical centers with a feasibility, safety, and efficacy comparable to that of NINDS trial. This question was answered by many community studies, which evaluated t-PA therapy in acute ischemic stroke. This chapter discusses community experience with intravenous t-PA in stroke treatment from 1996 to the present. Those studies are discussed in chronological order, highlighting the outcome and complication rates of each. Table 1 summarizes the results.


Acute Stroke Acute Ischemic Stroke Protocol Violation Intravenous Thrombolysis Acute Ischemic Stroke Patient 
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Copyright information

© Humana Press Inc., Totowa, NJ 2005

Authors and Affiliations

  • Lama Al-Khoury
    • 1
  • Christy M. Jackson
    • 1
  1. 1.UCSD Stroke CenterSan Diego

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