Abstract
Appropriate treatment of type 2 diabetes is dependent on the knowledge of the pathophysiology of the disease, the mechanisms underlying hyperglycemia, and the efficacy of various oral agents and insulins to improve fasting or postprandial hyperglycemia.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
DeFronzo RA. (1997) Pathogenesis of type 2 diabetes: metabolic and molecular implications for identifying diabetes genes. Diabetes Reviews 5:177–269.
LeRoith D. (2002) Beta-cell dysfunction and insulin resistance in type 2 diabetes: role of metabolic and genetic abnormalities. Am J Med 113(Suppl 6A):3S–11S.
Goldstein BJ. (2002) Insulin resistance as the core defect in type 2 diabetes mellitus. Am J Cardiol 90:3G–10G.
Henry RR. (1996) Glucose control and insulin resistance in non-insulin-dependent diabetes mellitus. Ann Intern Med 124:97–103.
Grundy SM. (2002) Obesity, metabolic syndrome, and coronary atherosclerosis. Circulation 105:2696–2698.
Atkinson MA, Maclaren NK. (1994) The pathogenesis of insulin-dependent diabetes mellitus. N Engl J Med 331:1428–1436.
Steinberg HO, Chaker H, Leaming R, Johnson A, Brechtel G, Baron AD. (1996) Obestiy/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. J Clin Invest 97:2601–2610.
Narayan KM, Imperatore G, Benjamin SM, Engelgau MM. (2002) Targeting people with pre-diabetes. BMJ 325:403–404.
Young TK, Martens PJ, Taback SP, et al. (2002) Type 2 diabetes mellitus in children: prenatal and early infancy risk factors among native Canadians. Arch Pediatr Adoles Med 156:651–655.
Jack L, Boseman L, Vinicor F. (2004) Aging Americans and diabetes. A public health and clinical response. Geriatrics 59:14–17.
Sinha R, Fisch G, Teague B, et al. (2002) Prevalence of impaired glucose tolerance among children and adolescents with marked obesity. N Engl J Med 346:802–810.
Fagan TC, Deedwania PC. (1998) The cardiovascular dysmetabolic syndrome. Am J Med 105(Suppl 1A):77S–82S.
Cubeddu LX, Hoffmann IS. (2002) Insulin resistance and upper-normal glucose levels in hypertension: a review. J Hum Hypertens 16(Suppl 1):S52–S55.
McFarlane SI, Banerji M, Sowers JR. (2001) Insulin resistance and cardiovascular disease. J Clin Endocrinol Metab 86:713–718.
Deedwania PC. (2000) Mechanism of the deadly quartet. Can J Cardiol 16(Suppl E):17E–20E.
American Diabetes Association. (1998) Consensus Development Conference on Insulin Resistance. 5–6 November 1997. Diabetes Care 21:310–314.
Rose G. (1989) High-risk and population strategies of prevention: ethical considerations. Ann Med 21:409–413.
Narayan KM, Boyle JP, Thompson TJ, Sorensen SW, Williamson DF. (2003) Lifetime risk for diabetes mellitus in the United States. JAMA 290:1884–1890.
Harris MI. (1993) Undiagnosed NIDDM: clinical and public health issues. Diabetes Care 16:642–652.
United Kingdom Prospective Diabetes Study (UKPDS) Group. (1998) Intensive blood-glucose control with sulfonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 352:837–853.
Rights and permissions
Copyright information
© 2005 Humana Press Inc., Totowa, NJ
About this chapter
Cite this chapter
(2005). Pathophysiology of Type 2 Diabetes. In: Type 2 Diabetes, Pre-Diabetes, and the Metabolic Syndrome. Current Clinical Practice. Humana Press. https://doi.org/10.1385/1-59259-932-X:1
Download citation
DOI: https://doi.org/10.1385/1-59259-932-X:1
Publisher Name: Humana Press
Print ISBN: 978-1-58829-471-5
Online ISBN: 978-1-59259-932-5
eBook Packages: MedicineMedicine (R0)