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Neural Development and Stem Cells pp 49–65Cite as

Cellular and Molecular Properties of Multipotent Neural Stem Cells Throughout Ontogeny

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Part of the book series: Contemporary Neuroscience ((CNEURO))

Abstract

Single cells isolated from the both the developing and the adult central nervous system (CNS) can give rise to neurons, astrocytes and oligodendrocytes and retain the ability to self-renew, in vitro. This observation has led to the conclusion that the CNS develops from multipotent, self-renewing stem cells (CNS stem cells) (1–9). However, since the isolation of CNS stem cells from embryonic and adult CNS (1,3,4,6,10,11), identification of their origin in vivo remains unclear (12,13). Moreover, the cellular and molecular relationship between neural stem cell populations at different stages of ontogeny and different anatomical regions is unresolved. To understand exactly what characteristics define neural stem cell identity in vivo and in vitro it is first necessary to elucidate the lineage relationship between the various types of stem cells and how they contribute to the development, differentiation, maintenance, and function of the CNS (14). To achieve this certain methodologies need to be developed for the direct isolation and characterization of neural stem cells from the embryonic and adult CNS.

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  1. Neuroscience Center, Department of Genetics, University of North Carolina, Chapel Hill, NC

    Larysa Halyna Pevny

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  1. Larysa Halyna Pevny
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  1. National Institute on Aging, Baltimore, MD

    Mahendra S. Rao MBBS, PhD

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Pevny, L.H. (2006). Cellular and Molecular Properties of Multipotent Neural Stem Cells Throughout Ontogeny. In: Rao, M.S. (eds) Neural Development and Stem Cells. Contemporary Neuroscience. Humana Press. https://doi.org/10.1385/1-59259-914-1:049

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