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Multiple Sclerosis

A Disease of Miscommunication Between the Immune and Central Nervous Systems?

  • Chapter
Inflammatory Disorders of the Nervous System

Part of the book series: Current Clinical Neurology ((CCNEU))

Abstract

A functional central nervous system (CNS) is essential for mammalian survival; therefore, the CNS must be defended from insults and other pathogens. The molecules (e.g., free radicals, cytokines, proteases) produced in vast quantities by the activated immune system to combat pathogens have the demonstrated potential to disrupt CNS function (1–3). To balance these opposing needs, (sufficient defense of the CNS without loss of CNS function), the CNS and immune system have developed a unique relationship referred to as immune privilege. Disruptions in this unique relationship leading to disregulated CNS inflammation are now thought to contribute to the onset and progression of many diverse types of CNS pathology, including CNS autoimmune diseases such as multiple sclerosis (MS), Rasmussen’s encephalitis, and narcolepsy; neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and stroke; and the secondary neurodegeneration associated with spinal cord injury (3–10).

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Authors and Affiliations

  1. Division of Biomedical Sciences, University of California, Riverside, CA

    Monica J. Carson PhD

  2. Department of Cellular and Molecular Physiology, The Scripps Research Institute, La Jolla, CA

    Crystal S. Anglen PhD

  3. Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA

    Corinne Ploix PharmD, PhD

Authors
  1. Monica J. Carson PhD
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  2. Crystal S. Anglen PhD
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  3. Corinne Ploix PharmD, PhD
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Editors and Affiliations

  1. Louisiana State University Health Science Center, Shreveport, LA

    Alireza Minagar MD  & J. Steven Alexander PhD  & 

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© 2005 Humana Press Inc., Totowa, NJ

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Carson, M.J., Anglen, C.S., Ploix, C. (2005). Multiple Sclerosis. In: Minagar, A., Alexander, J.S. (eds) Inflammatory Disorders of the Nervous System. Current Clinical Neurology. Humana Press. https://doi.org/10.1385/1-59259-905-2:017

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  • DOI: https://doi.org/10.1385/1-59259-905-2:017

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-424-1

  • Online ISBN: 978-1-59259-905-9

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