Abstract
Mitral regurgitation (MR), a common finding, is clinically significant, in part the result of its detrimental effect on left ventricular function. Patients with mild MR can remain asymptomatic for many years. However, moderate to severe MR gradually produces ventricular contractile dysfunction and dilation. Although left ventricular filling pressures are initially maintained in the near-normal range, ultimately left ventricular failure occurs and clinical symptoms develop. Because MR causes volume overload of the left ventricle, a vicious cycle develops. Volume overload leads to remodeling with left ventricular dilation and consequent left ventricular dysfunction. Left ventricular dilation also produces abnormalities of mitral valve support and enlargement of the mitral annulus. These changes lead to progressive worsening of MR (1).
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© 2005 Humana Press Inc., Totowa, NJ
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St. Goar, F.G., Fann, J.I., Feldman, T.E., Block, P.C., Herrmann, H.C. (2005). Percutaneous Mitral Valve Repair with the Edge-to-Edge Technique. In: Herrmann, H.C. (eds) Interventional Cardiology. Contemporary Cardiology. Humana Press. https://doi.org/10.1385/1-59259-898-6:087
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DOI: https://doi.org/10.1385/1-59259-898-6:087
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