Abstract
Vitamin D is a pro-hormone with a wide variety of biological actions once converted to its biologically active compound 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]. Its classical effect in the prevention and treatment of rickets has been known for over a century (1). More recently, nonclassical actions of vitamin D have been recognized and, in particular, its potent action on the proliferation and differentiation of a variety of cells, including normal and malignant cells (2). In this chapter, we first review the biological effects of vitamin D. We then describe the structure and functions of a variety of vitamin D analogs. Finally, we give a detailed description of the many studies that investigated the activity and the mechanism of the effect of vitamin D analogs in tumor growth and metastasis.
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Kremer, R., Rabbani, S.A. (2005). Vitamin D and Vitamin D Analogs in Cancer Progression and Metastasis. In: Singh, G., Rabbani, S.A. (eds) Bone Metastasis. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1385/1-59259-892-7:029
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