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Gene Therapy for Celebral Arterial Diseases

  • Chapter
Cardiovascular Genomics

Part of the book series: Contemporary Cardiology ((CONCARD))

Abstract

Although there has been steady progress towards cardiovascular gene therapy in humans, gene therapy for cerebrovascular disorders is still in its infancy. Several major steps, including gene transfer to cerebral arteries and alteration of gene expression, have been taken. There are several promising targets for cerebrovascular gene therapy, such as prevention of cerebral vasospasm after subarachnoid hemorrhage, stimulation of formation of collateral vessels to ischemic brain, and treatment of atherosclerotic lesions in carotid arteries. Some major obstacles, however, must be overcome before cerebrovascular gene therapy can be clinically used in humans. A key to cerebrovascular gene therapy is the development of safe and effective vectors for gene/nucleotide delivery. In addition, advances in understanding the biology of diseases and vectors will be of great value.

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Authors and Affiliations

  1. Cardiovascular Center, Department of Internal Medicine, University of Iowa College of Medicine and Veterans Affairs Medical Center, Iowa City, IA

    Yoshimasa Watanabe MD & Donald D. Heistad MD

  2. Cardiovascular Center, Department of Pharmacology, University of Iowa College of Medicine and Veterans Affairs Medical Center, Iowa City, IA

    Yoshimasa Watanabe MD & Donald D. Heistad MD

Authors
  1. Yoshimasa Watanabe MD
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  2. Donald D. Heistad MD
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Editor information

Editors and Affiliations

  1. Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, FL

    Mohan K. Rai ADA PhD

  2. Department of Physiology, School of Medical Sciences, University of Bristol, Bristol, UK

    Julian F. R. Paton PhD  & Sergey Kasparov MD, PhD  & 

  3. Department of Pharmacodynamics, University of Florida College of Pharmacy, Gainesville, FL

    Michael J. Katovich PhD

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Watanabe, Y., Heistad, D.D. (2005). Gene Therapy for Celebral Arterial Diseases. In: Rai, M.K., Paton, J.F.R., Kasparov, S., Katovich, M.J. (eds) Cardiovascular Genomics. Contemporary Cardiology. Humana Press. https://doi.org/10.1385/1-59259-883-8:285

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  • DOI: https://doi.org/10.1385/1-59259-883-8:285

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-400-5

  • Online ISBN: 978-1-59259-883-0

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