Abstract
Tourette’s syndrome (TS) is a neuropsychiatric disorder characterized by motor and phonic tics such as eye-blinks and grunts, respectively. It usually manifests in the first decade of life, and may be a considerable source of morbidity as it waxes and wanes. Advances in neuroscience, psychopharmacology, and psychotherapy are improving our understanding and the treatment of TS. Multimodal interventions that include focused treatment of comorbid conditions as well as educational and long term supportive relationships are usually the best approach.
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References
Leckman JF. Tourette’s syndrome. Lancet 2002;360:1577–1586.
Graybiel AM, Canales JJ. The neurobiology of repetitive behaviors: Clues to the neurobiology of Tourette syndrome. Adv Neurol 2001;85:123–131.
Mink JW. Basal ganglia dysfunction in Tourette’s syndrome: A new hypothesis. Pediatr Neurol 2001;25:190–198.
Alexander GE, DeLong MR. Microstimulation of the primate neostriatum. I. Physiological properties of striatal microexcitable zones. J Neurophysiol 1998;53:1401–1416.
Saka E, Iadarola M, Fitzgerald DJ, Graybiel AM. Local circuit neurons in the striatum regulate neural and behavioral responses to dopaminergic stimulation. Proc Natl Acad Sci USA 2002;99:9004–9009.
Peterson BS, Thomas P, Kane MJ, et al. Basal ganglia volumes in patients with Gilles de la Tourette syndrome. Arch Gen Psychiatry 2003;60:415–424.
Peterson BS, Skudlarski P, Anderson AW, et al. A functional magnetic resonance imaging study of tic suppression in Tourette syndrome. Arch Gen Psychiatry 1998;55:326–333.
Jeffries KJ, Schooler C, Schoenbach C, Herscovitch P, Chase TN, Braun AR. The functional neuroanatomy of Tourette’s syndrome: An FDG pet study III: Functional coupling of regional cerebral metabolic rates. Neuropsychopharmacology 2002;27:92–104.
Stern E, Silbersweig DA, Chee KY, et al. A functional neuroanatomy of tics in Tourette syndrome. Arch Gen Psychiatry 2000;57:741–748.
Swerdlow NR, Karban B, Ploum Y, Sharp R, Geyer MA, Eastvold A. Tactile prepuff inhibition of startle in children with Tourette’s syndrome: In search of an “fMRI-friendly” startle paradigm. Biol Psychiatry 2001;50:578–585.
Moll GH, Wischer S, Heinrich H, Tergau F, Paulus, Rothenberger A. Deficient motor control in children with tic disorder: Evidence from transcranial magnetic stimulation. Neurosci Lett 1999;272:37–40.
Swain JE, Leckman JF. Tourette’s Syndrome in Children. Current Treatment Options in Neurology 2003;5:299–308.
Singer HS, Szymanski S, Giuliano J, et al. Elevated intrasynaptic dopamine release in Tourette’s syndrome measured by pet. Am J Psychiatry 2002;159:1329–1336.
Wolf SS, Jones DW, Knable MB, et al. Tourette syndrome: Prediction of phenotypic variation in monozygotic twins by caudate nucleus D2 receptor binding. Science 1996;273:1225–1227.
Haber SN, Fudge JL, McFarland NR. Striatonigrostriatal pathways in primates form an ascending spiral from the shell to the dorsolateral striatum. J Neurosci 2000;20:2369–2382.
Muller-Vahl KR, Berding G, Brucke T, et al. Dopamine transporter binding in Gilles de la Tourette syndrome. J Neurol 2000;247:514–520.
Albin RL, Koeppe RA, Bohnen NI, et al. Increased ventral striatal monoaminergic innervation in Tourette syndrome. Neurol 2003;61:310–315.
Singer HS. Neurochemical analysis of postmortem cortical and striatal brain tissue in patients with Tourette syndrome. Adv Neurol 1992;58:135–144.
Stamenkovic M, Schindler SD, Asenbaum S, et al. No change in striatal dopamine re-uptake site density in psychotropic drug naive and in currently treated Tourette’s disorder patients: A [(123)I]-beta-CIT SPECT-study. Eur Neuropsychopharmacol 2001;11:69–74.
Anderson GM, Pollak ES, Chatterjee D, Leckman JF, Riddle MA, Cohen DJ. Postmortem analysis of subcortical monoamines and amino acids in Tourette syndrome. Adv Neurol 1992;58:123–133.
Swedo SE, Leonard HL, Garvey M, et al. Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: Clinical description of the first 50 cases. Am J Psychiatry 1998;155:264–271.
Kirvan CA, Swedo SE, Heuser JS, Cunningham MW. Mimicry and autoantibody-mediated neuronal cell signaling in Sydenham chorea. Nat Med 2003;9:914–920.
Taylor JR, Morshed SA, Parveen S, et al. An animal model of Tourette’s syndrome. Am J Psychiatry 2002;159:657–660.
Nordstrom EJ, Burton FH. A transgenic model of comorbid Tourette’s syndrome and obsessivecompulsive disorder circuitry. Mol Psychiatry 2002;7:617–625.
Schultz RT, Carter AS, Gladstone M, et al. Visual-motor integration functioning in children with Tourette syndrome. Neuropsychology 1998;12:134–145.
Muller SV, Johannes S, Wieringa B, et al. Disturbed monitoring and response inhibition in patients with Gilles de la Tourette syndrome and co-morbid obsessive compulsive disorder. Behav Neurol 2003;14:29–37.
Burd L, Severud R, Klug MG, Kerbeshian J. Prenatal and perinatal risk factors for Tourette disorder. J Perinat Med 1999;27:295–302.
Findley DB, Leckman JF, Katsovich L, et al. Development of the Yale children’s global stress index (YCGSI) and its application in children and adolescents with Tourette’s syndrome and obsessive-compulsive disorder. J Am Acad Child Adolesc Psychiatry 2003;42:450–457.
Robertson MM. Diagnosing Tourette syndrome. Is it a common disorder? J Psychosom Res 2003;55:3–6.
Snider LA, Seligman LD, Ketchen BR, Levitt SJ, Bates LR, Garvey MA, Swedo SE: Tics and problem behaviors in schoolchildren: prevalence, characterization, and associations. Pediatrics 2002;110:331–336.
Lin HY, Yeh CB, Peterson BS, et al. Assessment of symptom exacerbations in a longitudinal study of children with Tourette’s syndrome or obsessive-compulsive disorder. J Am Acad Child Adol Psychiatry 2002;41: 1070–1077.
Sukhodolsky DG, Scahill L, Zhang H, et al. Disruptive behaviors in children with Tourette’s syndrome: association with ADHD comorbidity, tic severity, and functional impairment. J Am Acad Child Adol Psychiatry 2003; 42:98–105.
Rapin I. Autism spectrum disorders: relevance to Tourette syndrome. Adv Neurol 2001;85: 89–101.
Robertson MM, Banerjee S, Kurlan R, et al. The Tourette syndrome diagnostic confidence index: Development and clinical associations. Neurol 1999;53:2108–2112.
Wilhelm S, Deckersbach T, Coffey BJ, Bohne A, Peterson AL, Baer L. Habit reversal versus supportive psychotherapy for Tourette’s disorder: a randomized controlled trial. Am J Psychiatry 2003;160: 1175–1177.
George MS, Sallee FR, Nahas Z, Oliver NC, Wasserman EM. Transcranial magnetic stimulation (TMS) as a research tool in Tourette syndrome and related disorders. Adv Neurol 2001;85: 225–235.
Marras C, Andrews D, Sime E, Lang AE. Botulinum toxin for simple motor tics: a randomized, double blind, controlled clinical trial. Neurol 2001;56:605–610.
Vandewalle V, van der Linden C, Groenewegen HJ, Caemaert J. Stereotactic treatment of Gilles de la Tourette syndrome by high frequency stimulation of thalamus. Lancet 1999;353:724.
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© 2005 Humana Press Inc., Totowa, NJ
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Swain, J.E., King, R.A., Leckman, J.F. (2005). Tourette’s Syndrome and Tic Disorders. In: Tarazi, F.I., Schetz, J.A. (eds) Neurological and Psychiatric Disorders. Current Clinical Neurology. Humana Press. https://doi.org/10.1385/1-59259-856-0:151
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DOI: https://doi.org/10.1385/1-59259-856-0:151
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