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Role of Ocular Motor Assessment in Diagnosis and Research

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Part of the book series: Current Clinical Neurology ((CCNEU))

Abstract

The clinical evaluation of eye movements can contribute substantially to the diagnosis of parkinsonian disorders, provided the physician performs a proper examination and interprets the findings by referring to a simple scheme of the neurobiology of eye movements (1). Further diagnostic information can often be obtained by recording eye movements, which are more accessible to measurement and analysis than limb movements or gait. A good part of the neurobiological substrate of eye movements has been defined, which makes it possible to attribute disordered properties of eye movements to dysfunction of specific neuronal populations or structures in the brain. In this chapter, first, we review pertinent aspects of the ocular motor examination; second, we highlight some important test paradigms and technical aspects of measuring eye movements; and third, we summarize disorders of ocular motility reported with parkinsonian disorders and diseases affecting the basal ganglia.

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References

  1. Leigh RJ, Zee DS. The neurology of eye movements. New York: Oxford University Press, 1999.

    Google Scholar 

  2. Becker W. Metrics. In: Wutz RH, Goldberg ME, eds. The Neurobiology of Saccadic Eye Movements. Amsterdam: Elsevier, 1989: 13–67.

    Google Scholar 

  3. Scudder CA, Kaneko CS, Fuchs AF. The brainstem burst generator for saccadic eye movements: a modern synthesis. Exp Brain Res 2002; 142(4):439–462.

    Article  PubMed  Google Scholar 

  4. Chamberlain W. Restriction of upward gaze with advancing age. Am J Ophthalmol 1971;71:341–346.

    CAS  PubMed  Google Scholar 

  5. Demer JL. Pivotal role of orbital connective tissues in binocular alignment and strabismus. Invest Ophthalmol Vis Sci 2004;45(3):729–738.

    Article  PubMed  Google Scholar 

  6. Huaman AG, Sharpe JA. Vertical saccades in senescence. Invest Ophthalmol Vis Sci 1993;34:2588–2595.

    PubMed  CAS  Google Scholar 

  7. Vidailhet M, Rivaud S, Gouider-Khouja N, Bonnet A, Gaymard B, Agid Y, et al. Eye movements in parkinsonian syndromes. Ann Neurol 1994;35:420–426.

    Article  PubMed  CAS  Google Scholar 

  8. Bhidayasiri R, Riley DE, Somers JT, Lerner AJ, Buttner-Ennever JA, Leigh RJ. Pathophysiology of slow vertical saccades in progressive supranuclear palsy. Neurology 2001;57(11):2070–2077.

    PubMed  CAS  Google Scholar 

  9. DiScenna AO, Das VE, Zivotofsky AZ, Seidman SH, Leigh RJ. Evaluation of a video tracking device for measurement of horizontal and vertical eye rotations during locomotion. J Neurosci Methods 1995;58:89–94.

    Article  PubMed  CAS  Google Scholar 

  10. Lebedev S, Van Gelder P, Tsui WH. Square-root relation between main saccade parameters. Invest Ophthalmol Vis Sci 1996;37:2750–2758.

    PubMed  CAS  Google Scholar 

  11. Garbutt S, Riley DE, Kumar AN, Han U, Harwood MR, Leigh RJ. Abnormalities of optokinetic nystagmus in progressive supranuclear palsy, J Neurosurg Psychiatry 2004, in press.

    Google Scholar 

  12. Pierrot-Deseilligny C, Ploner CJ, Muri RM, Gaymard B, Rivaud-Pechoux S. Effects of cortical lesions on saccadic: eye movements in humans. Ann N Y Acad Sci 2002;956:216–229.

    PubMed  Google Scholar 

  13. Hikosaka O, Takikawa Y, Kawagoe R. Role of the basal ganglia in the control of purposive saccadic eye movements. Physiol Rev 2000;80(3):953–978.

    PubMed  CAS  Google Scholar 

  14. Itoh H, Nakahara H, Hikosaka O, Kawagoe R, Takikawa Y, Aihara K. Correlation of primate caudate neural activity and saccade parameters in reward-oriented behavior. J Neurophysiol 2003;89:1774–1783.

    Article  PubMed  Google Scholar 

  15. Sato M, Hikosaka O. Role of primate substantia nigra pars reticulata in reward-oriented saccadic eye movement. J Neurosci 2002;22(6):2363–2373.

    PubMed  CAS  Google Scholar 

  16. Cui D, Yan Y, Lynch J. Pursuit subregion of the frontal eye field projects to the caudate nucleus in monkeys. J Neurophysiol 2003;89:2678–2684.

    Article  PubMed  Google Scholar 

  17. Crawford TJ, Bennett D, Lekwuwa G, Shaunak S, Deakin JF. Cognition and the inhibitory control of saccades in schizophrenia and Parkinson’s disease. Prog Brain Res 2002;140:449–466.

    PubMed  CAS  Google Scholar 

  18. Rascol O, Sabatini U, Simonetta-Moreau M, Montastruc JL, Rascol A, Clanet M. Square wave jerks in Parkinsonian syndromes. J Neurol Neurosurg Psychiatry 1991;54:599–602.

    PubMed  CAS  Google Scholar 

  19. O’Sullivan JD, Maruff P, Tyler P, Peppard RF, McNeill P, Currie J. Unilateral pallidotomy for Parkinson’s disease disrupts ocular fixation. J Clin Neurosci 2003;10(2):181–185.

    Article  PubMed  Google Scholar 

  20. White OB, Saint-Cyr JA, Tomlinson RD, Sharpe J. Ocular motor deficits in Parkinson’s disease. II: Control of saccadic and smooth pursuit systems. Brain 1983;106:571–587.

    Article  PubMed  Google Scholar 

  21. Rottach KG, Riley DE, DiScenna AO, Zivotofsky AZ, Leigh RJ. Dynamic properties of horizontal and vertical eye movements in parkinsonian syndromes. Ann Neurol 1996;39:368–377.

    Article  PubMed  CAS  Google Scholar 

  22. Repka MX, Claro MC, Loupe DN, Reich S. Ocular motility in Parkinson’s disease. Pediatr Ophthalmol Strabismus 1996;33:144–147.

    CAS  Google Scholar 

  23. Kimmig H, Haussmann K, Mergner T, Lucking CH. What is pathological with gaze shift fragmentation in Parkinson’s disease? J Neurol 2002;249(6):683–692.

    Article  PubMed  Google Scholar 

  24. Crawford T, Goodrich S, Henderson L, Kennard C. Predictive responses in Parkinson’s disease: Manual key presses and saccadic eye movements to regular stimulus events. J Neurol Neurosurg Psychiatry 1989;52:1033–1042.

    PubMed  CAS  Google Scholar 

  25. Lueck CJ, Crawford TJ, Henderson L, Van Gisbergen JA, Duysens J, Kennard C. Saccadic eye movements in Parkinson’s disease: II. Remembered saccades-towards a unified hypothesis? Quart J Exp Psychol 1992;45A:211–233.

    Google Scholar 

  26. Nakamura T, Bronstein AM, Lueck CJ, Marsden CD, Rudge P. Vestibular, cervical and visual remembered saccades in Parkinson’s disease. Brain 1994;117:1423–1432.

    Article  PubMed  Google Scholar 

  27. Vermersch AI, Rivaud S, Vidailhet M, Bonnet A, Gaymard B, Agid Y, et al. Sequences of memory-guided saccades in Parkinson’s disease. Ann Neurol 1994;35:487–490.

    Article  PubMed  CAS  Google Scholar 

  28. Kimmig H, Haussmann K, Mergner T, Lucking CH. What is pathological with gaze shift fragmentation in Parkinson’s disease? J Neurol 2002;249(6):683–692.

    Article  PubMed  Google Scholar 

  29. MacAskill MR, Anderson TJ, Jones RD. Saccadic adaptation in neurological disorders. Prog Brain Res 2002;140: 417–431.

    PubMed  Google Scholar 

  30. Bronstein AM, Kennard C. Predictive ocular motor control in Parkinson’s disease. Brain 1985;108:925–940.

    Article  PubMed  Google Scholar 

  31. Ventre J, Zee DS, Papageorgiou H, Reich S. Abnormalities of predictive saccades in hemi-parkinson’s disease. Brain 1992;115:1147–1165.

    Article  PubMed  Google Scholar 

  32. Nenadic I, Gaser C, Volz H, Rammsayer T, Hager F, Sauer H. Processing of temporal information and the basal ganglia: new evidence from fMRI. Exp Brain Res 2003;148:238–246.

    PubMed  Google Scholar 

  33. Turner R, Grafton S, McIntosh A, DeLong M, Hoffman J. The functional anatomy of parkinsonian bradykinesia. Neuroimage 2003;19:163–179.

    Article  PubMed  Google Scholar 

  34. Djamgoz M, Hankins M, Hirano J, Archer S. Neurobiology of retinal dopamine in relation to degenerative states of the tissue. Vision Res 1997;37:3509–3529. 1997.

    Article  PubMed  CAS  Google Scholar 

  35. Waterston JA, Barnes GR, Grealy MA, Collins S. Abnormalities of smooth eye and head movement control in Parkinson’s disease. Ann Neurology 1996;39:749–760.

    Article  CAS  Google Scholar 

  36. Rascol O, Clanet M, Montastruc JL, Simonetta M, Soulier-Esteve MJ, Doyon B, et al. Abnormal ocular movements in Parkinson’s disease. Evidence for involvement of dopaminergic systems. Brain 1989;112:1193–1214.

    Article  PubMed  Google Scholar 

  37. White OW, Saint-Cyr JA, Sharpe JA. Ocular motor deficits in Parkinson’s disease. I. The horizontal vestibulo-ocular reflex and its regulation. Brain 1983;106:555–570.

    Article  PubMed  Google Scholar 

  38. Reichert WH, Doolittle J, McDowell FH. Vestibular dysfunction in Parkinson’s disease. Neurology 1982;32:1133–1138.

    PubMed  CAS  Google Scholar 

  39. Gibson JM, Pimlott R, Kennard C. Ocular motor and manual tracking in Parkinson’s disease and the effect of treatment. J Neurol Neurosurg Psychiatry 1987;50:853–860.

    PubMed  CAS  Google Scholar 

  40. Blekher T, Siemers E, Abel LA, Yee RD. Eye movements in Parkinson’s disease: before and after pallidotomy. Invest Ophthalmol Vis Sci 2000;41(8):2177–2183.

    PubMed  CAS  Google Scholar 

  41. Rivaud-Pechoux S, Vermersch AI, Gaymard B, Ploner CJ, Bejjani BP, Damier P, et al. Improvement of memory guided saccades in parkinsonian patients by high frequency subthalamic nucleus stimulation. J Neurol Neurosurg Psychiatry 2000;68(3):381–384.

    Article  PubMed  CAS  Google Scholar 

  42. Carbon M, Ghilardi M, Feigin A, Fukuda M, Silvestri G, Mentis M, et al. Learning networks in health and Parkinson’s disease: reproducibility and treatment effects. Hum Brain Mapp 2003;19:197–211.

    Article  PubMed  Google Scholar 

  43. O’Sullivan JD, Maruff P, Tyler P, Peppard RF, McNeill P, Currie J. Unilateral pallidotomy for Parkinson’s disease disrupts ocular fixation. J Clin Neurosci 2003;10(2):181–185.

    Article  PubMed  Google Scholar 

  44. Averbuch-Heller L, Stahl JS, Hlavin ML, Leigh RJ. Square wave jerks induced by pallidotomy in parkinsonian patients. Neurology 1999;52:185–188.

    PubMed  CAS  Google Scholar 

  45. Hotson JR, Langston EB, Langston JW. Saccade responses to dopamine in human MTPT-induced parkinsonism. Ann Neurol 1986;20:456–463.

    Article  PubMed  CAS  Google Scholar 

  46. Schultz W, Romo R, Scarnati E, Sundstrom E, Jonsson G, Studer A. Saccadic reaction times, eye-arm coordination and spontaneous eye movements in normal and MTPT-treated monkeys. Exp Brain Res 1989;78:253–267.

    Article  PubMed  CAS  Google Scholar 

  47. Brooks BA, Fuchs AF, Finochio D. Saccadic eye movement deficits in the MTPT monkey model of Parkinson’s disease. Brain Res 1986;383:402–407.

    Article  PubMed  CAS  Google Scholar 

  48. Nath U, Ben-Shlomo Y, Thomson R, Lees A, Burn D. Clinical features and natural history of progressive supranuclear palsy. A clinical cohort study. Neurology 2003;60:910–916.

    PubMed  CAS  Google Scholar 

  49. Davis PH, Bergeron C, McLachlan DR. Atypical presentation of progressive supranuclear palsy. Ann Neurol 1985;17:337–343.

    Article  PubMed  CAS  Google Scholar 

  50. Quinn N. The “round the houses” sign in progressive supranuclear palsy. Ann Neurol 2003;40:951.

    Article  Google Scholar 

  51. Das V, Leigh R. Visual-vestibular interaction in progressive supranuclear palsy. Vision Res 2000;40:2077–2081.

    Article  PubMed  CAS  Google Scholar 

  52. Seemungal B, Faldon M, Revesz T, Lees A, Zee D, Bronstein A. Influence of target size on vertical gaze palsy in a pathologically proven case of progressive supranuclear palsy. Mov Disord 2003;18:818–822.

    Article  PubMed  Google Scholar 

  53. Bhidayasiri R, Riley DE, Somers JT, Lerner AJ, Buttner-Ennever JA, Leigh RJ. Pathophysiology of slow vertical saccades in progressive supranuclear palsy. Neurology 2001;57(11):2070–2077.

    PubMed  CAS  Google Scholar 

  54. Mastaglia FL, Grainger KMR. Internuclear ophthalmoplegia in progressive supranuclear palsy. J Neurol Sci 1975;25:303–308.

    Article  PubMed  CAS  Google Scholar 

  55. Kitthaweesin K, Riley DE, Leigh RJ. Vergence disorders in progressive supranuclear palsy. Ann N Y Acad Sci 2002;956:504–507.

    PubMed  Google Scholar 

  56. Jenkyn LR, Walsh DB, Walsh BT, Culver CM, Reeves AG. The nuchocephalic reflex. J Neurosurg Psychiatry 1975;38:561–566.

    CAS  Google Scholar 

  57. Kuniyoshi S, Riley DE, Zee DS, Reich SG, Whitney C, Leigh RJ. Distinguishing progressive supranuclear palsy from other forms of Parkinson’s disease: evaluation of new signs. Ann N Y Acad Sci 2002;956:484–486.

    Article  PubMed  Google Scholar 

  58. Bhidayasiri R, Riley DE, Somers JT, Lerner AJ, Buttner-Ennever JA, Leigh RJ. Pathophysiology of slow vertical saccades in progressive supranuclear palsy. Neurology 2001;57(11):2070–2077.

    PubMed  CAS  Google Scholar 

  59. Garbutt S, Harwood M, Kumar A, Han Y, Leigh R. Evaluating small eye movements in patients with saccadic palsies. Ann NY Acad Soc 2003;1004:337–346.

    Article  Google Scholar 

  60. Bhidayasiri R, Plant GT, Leigh RJ. A hypothetical scheme for the brainstem control of vertical gaze. Neurology 2000;54(10):1985–1993.

    PubMed  CAS  Google Scholar 

  61. Bhidayasiri R, Riley DE, Somers JT, Lerner AJ, Buttner-Ennever JA, Leigh RJ. Pathophysiology of slow vertical saccades in progressive supranuclear palsy. Neurology 2001;57(11):2070–2077.

    PubMed  CAS  Google Scholar 

  62. Pierrot-Deseilligny C, Rivaud S, Fournier E, Agid Y. Lateral visually-guided saccades in progressive supranuclear palsy. Brain 1989;112:471–487.

    Article  PubMed  Google Scholar 

  63. Goffinet AM, DeVolder AG, Gillian C, Rectem D, Bol A, Michel C et al. Positron tomography demonstrates frontal lobe hypometabolism in progressive supranuclear palsy. Ann Neurol 1989;25:131–139.

    Article  PubMed  CAS  Google Scholar 

  64. Kitthaweesin K, Riley DE, Leigh RJ. Vergence disorders in progressive supranuclear palsy. Ann N Y Acad Sci 2002;956:504–507.

    PubMed  Google Scholar 

  65. Moses HI, Zee DS. Multi-infarct PSP. Neurology 1987;37:1819.

    Google Scholar 

  66. Bhidayasiri R, Plant GT, Leigh RJ. A hypothetical scheme for the brainstem control of vertical gaze. Neurology 2000;54(10):1985–1993.

    PubMed  CAS  Google Scholar 

  67. Averbuch-Heller L, Paulson G, Daroff R, Leigh R. Whipple’s disease mimicking progressive supranuclear palsy: the diagnostic value of eye movement recording. J Neurol Neurosurg Psychiatry 1999;66:532–535.

    PubMed  CAS  Google Scholar 

  68. Knox DL, Green WR, Troncosa JC, Yardley JH, Hsu J, Zee DS. Cerebral ocular Whipple’s disease: a 62 year-old odyssey from death to diagnosis. Neurology 1995;45:617–625.

    PubMed  CAS  Google Scholar 

  69. Schwartz MA, Selhorst JB, Ochs AL, Beck RW, Campbell WW, Harris JK, et al. Oculomasticatory myorhythmia: a unique movement disorder occurring in Whipple’s disease. Ann Neurol 1986;20:677–683.

    Article  PubMed  CAS  Google Scholar 

  70. Lowsky R, Archer GL, Fyles G, Minden M, Curtis J, Messner H, et al. Diagnosis of Whipple’s disease by molecular analysis of peripheral blood. N Engl J Med 1994;331:1343–1346.

    Article  PubMed  CAS  Google Scholar 

  71. Fleming JL, Wiesner RH, Shorter RG. Whipple’s disease: clinical, biochemical, and histopathological features and assessment of treatment in 29 patients. Mayo Clin Proc 1988;63:539–551.

    PubMed  CAS  Google Scholar 

  72. Riley DE, Fogt N, Leigh RJ. The syndrome of “pure akinesia” and its relationship to progressive supranuclear palsy. Neurology 1994;44:1025–1029.

    PubMed  CAS  Google Scholar 

  73. Vidailhet M, Rivaud-Pechoux S. Eye movement disorders in corticobasal degeneration. Adv Neurol 2000;82:161–167.

    PubMed  CAS  Google Scholar 

  74. Riley DE, Lang AE, Lewis A, Resch L, Ashby P, Hornykiewicz O et al. Cortical-basal ganglionic degeneration. Neurology 1990;40:1203–1212.

    PubMed  CAS  Google Scholar 

  75. Gibb WRG, Luthert PJ, Marsden CD. Corticobasal degeneration. Brain 1989;112:1171–1192.

    Article  PubMed  Google Scholar 

  76. Bhidayasiri R, Riley DE, Somers JT, Lerner AJ, Buttner-Ennever JA, Leigh RJ. Pathophysiology of slow vertical saccades in progressive supranuclear palsy. Neurology 2001;57(11):2070–2077.

    PubMed  CAS  Google Scholar 

  77. Bertholon P, Bronstein A, Davies R, Rudge P, Thilo K. Positional down beating nystagmus in 50 patients: cerebellar disorders and possible anterior semicircular canalithiasis. J Neurol Neurosurg Psychiatry 2002;72:366–372.

    Article  PubMed  CAS  Google Scholar 

  78. Brett F, Henson C, Staunton H. Familial diffuse Lewy body disease, eye movement abnormalities, and distribution of pathology. Arch Neurol 2003;59:464–467.

    Article  Google Scholar 

  79. de Bruin VM, Lees AJ, Daniel SE. Diffuse Lewy body disease presenting with supranuclear gaze palsy, parkinsonism, and dementia: a case report. Mov Disord 1992;7:355–358.

    Article  PubMed  Google Scholar 

  80. Saver JL, Liu GT, Charness ME. Idiopathic striopallidodentate calcification with prominent supranuclear abnormality of eye movement. J Neuro-ophthalmology 1994;14:29–33.

    CAS  Google Scholar 

  81. Wszolek ZK, Pfeiffer RF, Bhatt MH, Schelper RL, Cordes M, Snow BJ, et al. Rapidly progressive autosomal dominant parkinsonism and dementia with pallido-ponto-nigral degeneration. Ann Neurol 1992;32:312–320.

    Article  PubMed  CAS  Google Scholar 

  82. Lepore FE, Steele JC, Cox TA, Tillson G, Calne DB, Duvoisin RC, et al. Supranuclear disturbances of ocular motility in Lytico-Bodig. Neurology 1988;38:1849–1853.

    PubMed  CAS  Google Scholar 

  83. Averbuch-Heller L, Helmchen C, Horn AKE, Leigh RJ, Büttner-Ennever JA. Slow vertical saccades in motor neuron disease: correlation of structure and function. Ann Neurol 1998;44:641–648.

    Article  PubMed  CAS  Google Scholar 

  84. Caparros-Lefebvre D, Sergeant N, Lees A, Camuzat A, Daniel S, Lannuzel A, et al. Guadeloupean parkinsonism: a cluster of progressive supranuclear palsy-like tauopathy. Brain 2002;125:801–811.

    Article  PubMed  Google Scholar 

  85. Grant MP, Cohen M, Petersen RB, Halmagyi GM, McDougall A, Tusa RJ, et al. Abnormal eye movements in Creutzfeldt-Jakob disease. Ann Neurology 1993;34:192–197.

    Article  CAS  Google Scholar 

  86. Helmchen C, Büttner U. Centripetal nystagmus in a case of Creutzfeldt-Jakob disease. Neuro-ophthalmology 1995;15:187–192.

    Google Scholar 

  87. Leigh RJ, Foley JM, Remler BF, Civil RH. Oculogyric crisis: a syndrome of thought disorder and ocular deviation. Ann Neurol 1987;22:13–17.

    Article  PubMed  CAS  Google Scholar 

  88. Lees A, Kim Y, Lyoo C. Oculogyric crisis as an initial manifestation of Wilson’s disease. Neurology 1999;52:1714–1715.

    Google Scholar 

  89. Swoboda K, Hyland K, Goldstein D, Kuban K, Arnold L, Holmes C, et al. Clinical and therapeutic observations in aromatic L-amino decarboxylase deficiency. Neurology 1999;53:1205–1211.

    PubMed  CAS  Google Scholar 

  90. Liu GT, Carrazana EJ, Macklis JD, Mikati MA. Delayed oculogyric crises associated with striatocapsular infarction. J Clin Neuro-ophthalmol 1991;11:198–201.

    CAS  Google Scholar 

  91. Frankel M, Cummings JL. Neuro-ophthalmic abnormalities in Tourette’s syndrome. Functional and anatomical implications. Neurology 1984;34:359–361.

    PubMed  CAS  Google Scholar 

  92. FitzGerald PM, Jankovic J, Glaze DG, Schultz R, Percy AK. Extrapyramidal involvement in Rett’s syndrome. Neurology 1990;40:293–295.

    PubMed  CAS  Google Scholar 

  93. Hoyt CS, Mousel DK. Transient supranuclear disturbances of gaze in healthy neonates. Am J Ophthalmol 1980;89: 708–713.

    PubMed  CAS  Google Scholar 

  94. FitzGerald PM, Jankovic J. Tardive oculogyric crisis. Neurology 1989;39:1434–1437.

    PubMed  CAS  Google Scholar 

  95. Sachdev P. Tardive and chronically recurrent oculogyric crises. Mov Disord 1993;8:93–97.

    Article  PubMed  CAS  Google Scholar 

  96. Kim JS, Kim HK, Im JH, Lee MC. Oculogryic crisis and abnormal magnetic resonance imaging signals in bilateral lentiform nuclei. Mov Disord 1996;11:756–758.

    Article  PubMed  CAS  Google Scholar 

  97. Collewijn H, Went LN, Tamminga EP, Vegter-Van der Vlis M. Oculomotor defects in patients with Huntington’s disease and their offspring. J Neurol Sci 1988;86:307–320.

    Article  PubMed  CAS  Google Scholar 

  98. Lasker AG, Zee DS. Ocular motor abnormalities in Huntington’s disease. Vision Res 1997;37:3639–3645.

    Article  PubMed  CAS  Google Scholar 

  99. Lasker AG, Zee DS, Hain TC, Folstein SE, Singer HS. Saccades in Huntington’s disease: initiation defects and distractability. Neurology 1987;37:364–370.

    PubMed  CAS  Google Scholar 

  100. Leigh RJ, Newman SA, Folstein SE, Lasker AG, Jensen BA. Abnormal ocular motor control in Huntington’s disease. Neurology 1983;33:1268–1275.

    PubMed  CAS  Google Scholar 

  101. Zangemeister WH, Mueller-Jensen A. The coordination of gaze movements in Huntington’s disease. Neuro-ophthalmology 1985;5:193–206.

    Google Scholar 

  102. Rubin AJ, King WM, Reinbold KA, Shoulson I. Quantitative longitudinal assessment of saccades in Huntington’s disease. J Clin Neuro-opthalmol 1993;13:59–66.

    CAS  Google Scholar 

  103. Kirkwood SC, Siemers E, Bond C, Conneally PM, Christian JC, Foroud T. Confirmation of subtle motor changes among presymptomatic carriers of the Huntington disease gene. Arch Neurol 2000;57(7):1040–1044.

    Article  PubMed  CAS  Google Scholar 

  104. Rothlind JC, Brandt J, Zee D, Codori AM, Folstein S. Verbal memory and oculomotor control are unimpaired in asymptomatic adults with the genetic marker for Huntington’s disease. Arch Neurol 1993;50:799–802.

    PubMed  CAS  Google Scholar 

  105. Reveley MA, Dursun SM, Andrews H. Improvement of abnormal saccadic eye movements in Huntington’s disease by sulpiride: a case study. Journal of Psychopharmacology 1994;8:262–265.

    Article  Google Scholar 

  106. Lasker AG, Zee DS, Hain TC, Folstein SE, Singer HS. Saccades in Huntington’s disease: initiation defects and distractibility. Neurology 1987;37:364–370.

    PubMed  CAS  Google Scholar 

  107. Hikosaka O, Takikawa Y, Kawagoe R. Role of the basal ganglia in the control of purposive saccadic eye movements. Physiol Rev 2000;80(3):953–978.

    PubMed  CAS  Google Scholar 

  108. Oyanagi K, Takeda S, Takahashi H, Ohama E, Ikuta F. A quantitative investigation of the substantia nigra in Huntington’s disease. Ann Neurol 1989;26:13–19.

    Article  PubMed  CAS  Google Scholar 

  109. Koeppen AH. The nucleus pontis centralis caudalis in Huntington’s disease. J Neurol Sci 1989;91:129–141.

    Article  PubMed  CAS  Google Scholar 

  110. Leigh RJ, Parhad IM, Clark AW, Buettner-Ennever JA, Folstein SE. Brainstem findings in Huntington’s disease. J Neurol Sci 1985;71:247–256.

    Article  PubMed  CAS  Google Scholar 

  111. Rinne JO, Daniel SE, Scaravilli F, Pires M, Harding AE, Marsden CD. The neuropathological features of neuroacanthocytosis. Mov Disord 1994;9:297–304.

    Article  PubMed  CAS  Google Scholar 

  112. Burke JR, Wingfield MS, Lewis KE, Roses AD, Lee JE, Hulette C, et al. The haw river syndrome: dentatorubropallidoluysian atrophy (DRPLA) in an African-American family. Nat Genet 1994;7:521–524.

    Article  PubMed  CAS  Google Scholar 

  113. Lennox G, Jones R. Gaze distractibility in Wilson’s disease. Ann Neurol 1989;25:415–417.

    Article  PubMed  CAS  Google Scholar 

  114. Kirkham TH, Kamin DF. Slow saccadic eye movements in Wilson’s disease. J Neurol Neurosurg Psychiatry 1974;37:191–194.

    Article  PubMed  CAS  Google Scholar 

  115. Keane JR. Lid-opening apraxia in Wilson’s disease. J Clin Neuro-ophthalmol 1988;8:31–33.

    Article  CAS  Google Scholar 

  116. Lewis RF. Ocular motor apraxia and ataxia-telangiectasia. Arch Neurol 2001;58(8):1312.

    Article  PubMed  CAS  Google Scholar 

  117. Lewis RF, Crawford TO. Ocular motor abnormalities in ataxia telangiectasia. Neurology 1998;50(Suppl).

    Google Scholar 

  118. Lewis RF, Crawford TO. Slow target-directed eye movements in ataxia-telangiectasia. Invest Ophthalmol Vis Sci 2002;43(3):686–691.

    PubMed  Google Scholar 

  119. Stell R, Bronstein AM, Plant GT, Harding AE. Ataxia telangiectasia: a reappraisal of the ocular motor features and their value in the diagnosis of atypical cases. Mov Disord 1989;4:320–329.

    Article  PubMed  CAS  Google Scholar 

  120. Rottach KG, von Maydell RD, Das VE, Zivotofsky AZ, DiScenna AO, Gordon JL, et al. Evidence for independent feedback control of horizontal and vertical saccades from Niemann-Pick type C disease. Vision Res 1997;37:3627–3638.

    Article  PubMed  CAS  Google Scholar 

  121. Garbutt S, Harris CM. Abnormal vertical optokinetic nystagmus in infants and children. Br J Ophthalmol 2000;84(5):451–455.

    Article  PubMed  CAS  Google Scholar 

  122. Higgins JJ, Patterson MC, Dambrosia JM, Pikus AT, Pentchev PG, Sato S, et al. A clinical staging classification for type C Niemann-Pick disease. Neurology 1992;42:2286–2290.

    PubMed  CAS  Google Scholar 

  123. Stein RW, Kase CS, Hier DB, Caplan LR, Mohr JP. Caudate hemorrhage. Neurology 1984;34:1549–1554.

    PubMed  CAS  Google Scholar 

  124. Vermersch AI, RM M, Rivaud S, Vidailhet M, Gaymard B, Agid Y, et al. Saccade disturbances after bilateral lentiform nucleus lesions in humans. J Neurol Neurosurg Psychiatry 1996;60:179–184.

    PubMed  CAS  Google Scholar 

  125. Lekwuwa GU, Barnes GR. Cerebral control of eye movements. II. Timing of anticipatory eye movements, predictive pursuit and phase errors in focal cerebral lesions. Brain 1996;119:491–505.

    Article  PubMed  Google Scholar 

  126. Dursun SM, Burke JG, Reveley MA. Antisaccade eye movement abnormalities in Tourette syndrome: evidence for cortico-striatal network dysfunction? J Psychopharmacol 2000;14(1):37–39.

    Article  PubMed  CAS  Google Scholar 

  127. LeVasseur AL, Flanagan JR, Riopelle RJ, Munoz DP. Control of volitional and reflexive saccades in Tourette’s syndrome. Brain 2001;124(Pt 10):2045–2058.

    Article  PubMed  CAS  Google Scholar 

  128. Mostofsky SH, Lasker AG, Singer HS, Denckla MB, Zee DS. Oculomotor abnormalities in boys with Tourette syndrome with and without ADHD. J Am Acad Child Adolesc Psychiatry 2001;40(12):1464–1472.

    Article  PubMed  CAS  Google Scholar 

  129. Munoz DP, Le Vasseur AL, Flanagan JR. Control of volitional and reflexive saccades in Tourette’s syndrome. Prog Brain Res 2002;140:467–481.

    Article  PubMed  Google Scholar 

  130. Narita AS, Shawkat FS, Lask B, Taylor DS, Harris CM. Eye movement abnormalities in a case of Tourette syndrome. Dev Med Child Neurol 1997;39:270–273.

    Article  PubMed  CAS  Google Scholar 

  131. Straube A, Mennicken J-B, Riedel M, Eggert T, Müller N. Saccades in Gilles de la Tourette’s syndrome. Movement Disorders 1997;12:536–546.

    Article  PubMed  CAS  Google Scholar 

  132. Binyon S, Prendergast M. Eye-movement tics in children. Dev Med Child Neurol 1991;33:343–355.

    Google Scholar 

  133. Shawkat FS, Harris CM, Jacobs M, Taylor D, Brett EM. Eye movement tics. Brit J Ophthalmol 1992;76:697–699.

    Article  CAS  Google Scholar 

  134. Jinnah HA, Lewis RF, Visser JE, Eddey GE, Barabas G, Harris JC. Ocular motor dysfunction in Lesch-Nyhan disease. Pediatr Neurol 2001;24(3):200–204.

    Article  PubMed  CAS  Google Scholar 

  135. Demer JL, Holds JB, Hovis LA. Ocular movements in essential blepharospasm. Am J Ophthalmol 1990;110:674–682.

    PubMed  CAS  Google Scholar 

  136. Aramideh M, Bour LJ, Koelman JHTM, Speelman JD, Ongerboer de Visser BW. Abnormal eye movements in blepharospasm and involuntary levator palpebrae inhibition. Brain 1994;117:1457–1474.

    Article  PubMed  Google Scholar 

  137. Bollen E, Van Exel E, van der Velde EA, Buytels P, Bastiaanse J, van Dijk JG. Saccadic eye movements in idiopathic blepharospasm. Movement Disorders 1996;11:678–682.

    Article  PubMed  CAS  Google Scholar 

  138. Averbuch-Heller L, Rottach KG, Zivotofsky AZ, Suarez JI, Pettee AD, Remler BF et al. Torsional eye movements in patients with skew deviation and spasmodic torticollis: responses to static and dynamic head roll. Neurology 1997;48:506–514.

    PubMed  CAS  Google Scholar 

  139. Stell R, Bronstein AM, Marsden CD. Vestibulo-ocular abnormalites in spasmodic torticollis before and after botulinum toxin injections. J Neurol Neurosurg Psychiatry 1989;52:57–62.

    PubMed  CAS  Google Scholar 

  140. Anastasopoulos D, Nasios G, Psilas K, Mergner T, Maurer C, Lücking C-H. What is straight ahead to a patient with torticollis? Brain 1998;121:91–101.

    Article  PubMed  Google Scholar 

  141. Thaker GK, Nguyen JA, Tamminga CA. Increased saccadic distractibility in tardive dyskinesia: functional evidence for subcortical GABA dysfunction. Biol Psychiatry 1989;25:49–59.

    Article  PubMed  CAS  Google Scholar 

  142. Cardosa F, Eduardo C, Silva AP, Mota CCC. Chorea in fifty consecutive patients with rheumatic fever. Mov Disord 1997;12:701–703.

    Article  Google Scholar 

  143. Helmchen C, Hagenow A, Miesner J, Sprenger A, Rambold H, Wenzelburger R et al. Eye movement abnormalities in essential tremor may indicate cerebellar dysfunction. Brain 2003;126:1319–1392.

    Article  PubMed  CAS  Google Scholar 

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Leigh, R.J., Zee, D.S. (2005). Role of Ocular Motor Assessment in Diagnosis and Research. In: Litvan, I. (eds) Atypical Parkinsonian Disorders. Current Clinical Neurology. Humana Press. https://doi.org/10.1385/1-59259-834-X:235

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  • DOI: https://doi.org/10.1385/1-59259-834-X:235

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