History and Overview of Orexin/Hypocretin Research

From Orphan GPCR to Integrative Physiology
  • Michihiro Mieda
  • Takeshi Sakurai
Part of the Contemporary Clinical Neuroscience book series (CCNE)


Since its discovery in 1998, the field of orexin/hypocretin biology has grown rapidly. In the last 6 yr, more than 900 articles on orexin/hypocretin research have been published. Information on the role of the orexin/hypocretin system in narcolepsy-cataplexy has had a huge impact on the study of sleep and wakefulness. Scientists are now using a multidisciplinary approach to understand various aspects of the physiological functions of orexins/hypocretins in order to apply orexin/hypocretin biology to the diagnosis and treatment of sleep-related disorders.


Sodium Oxybate Rostral Ventromedial Medulla Rostral Ventrolateral Medulla Orexin Neuron Inhibitory Area 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Humana Press Inc., Totowa, NJ 2006

Authors and Affiliations

  • Michihiro Mieda
    • 1
  • Takeshi Sakurai
    • 2
    • 3
  1. 1.Department of Molecular Neuroscience, Medical Research InstituteTokyo Medical and Dental UniversityTokyoJapan
  2. 2.Department of Pharmacology, Institute of Basic Medical SciencesUniversity of TsukubaIbarakiJapan
  3. 3.ERATO Yanagisawa Orphan Receptor ProjectJapan Science and Technology AgencyTokyoJapan

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