Abstract
This chapter will describe the current pharmacological treatment of Post-Traumatic Stress Disorder (PTSD) and the classes of pharmacologic agents used in such treatment. However, pharmacotherapy for PTSD with co-occurring psychiatric disorders will also be highlighted and discussed.
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References
Baker, D. G., West, S. A., Nicholson, W. E. et al. (1999) ‘Serial CSF corticotropin-releasing hormone levels and adrenocortical activity in combat veterans with posttraumatic stress disorder’. American Journal of Psychiatry, 156: 585–8.
Berlant, J. and van Kammen, D. P. (2002) ‘Open-label topiramate as primary or adjunctive therapy in chronic civilian posttraumatic stress disorder: a preliminary report’. Journal of Clinical Psychiatry, 63: 15–20.
Brady, K., Pearlstein, T., Asnis, G. M. et al. (2000) ‘Efficacy and safety of sertraline treatment of posttraumatic stress disorder: a randomized controlled trial’. Journal of the American Medical Association, 283: 1837–44.
Braun, P., Greenberg, D., Dasberg, H. et al. (1990) ‘Core symptoms of post-traumatic stress disorder unimproved by alprazolam treatment’. Journal of Clinical Psychiatry, 51: 236–8.
Butterfield, M. I., Becker, M. E., Connor, K. M. et al. (2001) ‘Olanzapine in the treatment of post-traumatic stress disorder: a pilot study’. International Clinical Psychopharmacology, 16: 197–203.
Canive, J. M., Clark, R. D., Calais, L. A. et al. (1998) ‘Bupropion treatment in veterans with posttraumatic stress disorder: an open study’. Journal of Clinical Psychopharmacology, 18: 379–83.
Davidson, J. R., Kudler, H. S., Smith, R. et al. (1990) ‘Treatment of posttraumatic stress disorder with amitriptyline and placebo’. Archives of General Psychiatry, 47: 259–66.
Davidson, J. R., Weisler, R. H., Butterfield, M. I. et al. (2003) ‘Mirtazapine vs placebo in posttraumatic stress disorder: a pilot trial’. Biological Psychiatry, 53: 188–91.
Duffy, J. D. and Malloy, P. F. (1994) ‘Efficacy of buspirone in the treatment of posttraumatic stress disorder: an open trial’. Annals of Clinical Psychiatry, 6: 33–7.
Famularo, R., Kinscherff, R. and Fenton, T. (1988) ‘Propranolol treatment for childhood posttraumatic stress disorder, acute type: a pilot study’. American Journal of Diseases of Children, 142: 1244–7.
Fesler, F. A. (1991) ‘Valproate in combat-related posttraumatic stress disorder’. Journal of Clinical Psychiatry, 52: 361–4.
Forster, P. L., Schoenfeld, F. B., Marmar, C. R. et al. (1995) ‘Lithium for irritability in post-traumatic stress disorder’. Journal of Traumatic Stress, 8: 143–9.
Frank, J. B., Kosten, T., Giller, E. L. Jr et al. (1988) ‘A randomized clinical trial of phenylzine and imipramine for posttraumatic stress disorder’. American Journal of Psychiatry, 145: 1289–91.
Gelpin, E., Bonne, O., Peri, T. et al. (1996) ‘Treatment of recent trauma survivors with benzodiazepines: a prospective study’. Journal of Clinical Psychiatry, 57: 390–4.
Goddard, A. W., Woods, S. W., Sholomskas, D. E. et al. (1993) ‘Effects of the serotonin reuptake inhibitor fluvoxamine on yohimbine-induced anxiety in panic disorder’. Psychiatry Research, 48: 119–33.
Gregorian, R. S., Golden, K. A., Bache, A. et al. (2002) ‘Antidepressant-induced sexual dysfunction’. Annals of Pharmacotherapy, 36: 1577–89.
Grillon, C., Morgan, C. A., Southwick, S. M. et al. (1996) ‘Baseline startle amplitude and prepulse inhibition in Vietnam veterans with posttraumatic stress disorder’. Psychiatry Research, 64: 169–78.
Hamner, M. B., Brodrick, P. S. and Labbate, L. A. (2001) ‘Gabapentin in PTSD: a retrospective, clinical series of adjunctive therapy’. Annals of Clinical Psychiatry, 13: 141–6.
Hamner, M. B., Deitsch, S. E. and Brodrick, P. S. (2003) ‘Quetiapine treatment in patients with posttraumatic stress disorder: an open adjunctive therapy’. Journal of Clinical Psychopharmacology, 23: 15–20.
Harmon, R. J. and Riggs, P. (1996) ‘Clonidine for posttraumatic stress disorder in preschool children’. Journal of the American Academy of Child and Adolescent Psychiatry, 35: 1247–9.
Hertzberg, M. A., Butterfield, M. I., Feldman, M. E. et al. (1999) ‘A preliminary study of lamotrigine for the treatment of posttraumatic stress disorder’. Biological Psychiatry, 45: 1226–9.
Hertzberg, M. A., Feldman, M. E., Beckham, J. C. et al. (1996) ‘Trial of trazodone for posttraumatic stress disorder using a multiple baseline group design’. Journal of Clinical Psychopharmacology, 16: 294–8.
Hidalgo, R., Hertzberg, M. A., Mellman T. et al. (1999) ‘Nefazodone in post-traumatic stress disorder: results from six open-label trials’. International Clinical Psychopharmacology, 14: 61–8.
Horrigan, J. P. and Barnhill, L. J. (1996) ‘The suppression of nightmares with guanfacine’. Journal of Clinical Psychiatry, 57: 371.
Kaplan, H. I. and Sadock, B. (1998) Synopsis of Psychiatry, 8th edn. Baltimore: Lippincott Williams & Wilkins.
Keck, P. E. Jr, McElroy, S. L. and Friedman, L. M. (1992) ‘Valproate and carbamazepine in the treatment of panic and posttraumatic stress disorders, withdrawal states, and behavioral dyscontrol syndrome’. Journal of Clinical Psychopharmacology, 12: 36S–41S.
Kinzie, J. D. (1998) ‘Therapeutic approaches to traumatized Cambodian refugees’. Journal of Traumatic Stress, 2: 75–91.
Kinzie, J. D. and Leung, P. (1989) ‘Clonidine in Cambodian patients with posttraumatic stress disorder’. Journal of Nervous and Mental Disease, 177: 546–50.
Kitchner, I. and Greenstein, R. (1983) ‘Low-dose lithium carbonate in the treatment of posttraumatic stress disorder’. Hospital and Community Psychiatry, 34: 683–91.
Kolb, L. C., Burris, B. C. and Griffiths, S. (1984) ‘Propranolol and clonidine in the treatment of the chronic post traumatic stress disorders of war’, in Post-Traumatic Stress Disorder: Psychological and Biological Sequelae, ed, B. A. Van der Kolk. Washington DC: American Psychiatric Press.
Krashin, D. and Oates, E. W. (1999) ‘Risperidone as an adjunct therapy for post-traumatic stress disorder’. Military Medicine, 164: 605–6.
Lipper, S., Davidson, J. R., Grady, T. A. et al. (1986) ‘Preliminary study of carbamazepine in post-traumatic stress disorder’. Psychosomatics, 27: 849–54.
Marmar, C. R., Schoenfeld, F. B., Weiss, D. S. et al. (1996) ‘Open trial of fluvoxamine treatment for combat-related posttraumatic stress disorder’. Journal of Clinical Psychiatry, 57(suppl. 8): 66–72.
Marshall, R. D., Beebe, K. L., Oldham, M. et al. (2001) ‘Efficacy and safety of paroxetine treatment for chronic PTSD: a fixed-dose, placebo-controlled study’. American Journal of Psychiatry, 158: 1982–8.
Mellman, T. A., David, D. and Barza, L. (1999) ‘Nefazodone treatment and dream reports in chronic PTSD’. Depression and Anxiety, 9: 146–8.
Monnelly, E. P., Ciraulo, D. A., Knapp, C. et al. (2003) ‘Low-dose risperidone as adjunctive therapy for irritable aggression in posttraumatic stress disorder’. Journal of Clinical Psychopharmacology, 23: 193–6.
Neal, L. A., Shapland, W. and Fox, C. (1997) ‘An open trial of moclobemide in the treatment of post-traumatic stress disorder’. International Clinical Psychopharmacology, 12: 231–7.
Orr, S. P., Metzger, L. J., Lasko, N. B. et al. (2000) ‘De novo conditioning in trauma-exposed individuals with and without posttraumatic stress disorder’. Journal of Abnormal Psychology, 109: 290–8.
Petty, F., Brannan, S., Casada, J. et al. (2001) ‘Olanzapine treatment for post-traumatic stress disorder: an open-label study’. International Clinical Psychopharmacology, 16: 331–7.
Pitman, R. K. (1989) ‘Post-traumatic stress disorder, hormones, and memory’. Biological Psychiatry, 26: 221–3.
Pitman, R. K., Sanders, K. M., Zusman, R. M. et al. (2002) ‘Pilot study of secondary prevention of posttraumatic stress disorder with propranolol’. Biological Psychiatry, 51: 189–92.
Raskind, M. A., Peskind, E. R., Kanter, E. D. et al. (2003) ‘Reduction of nightmares and other PTSD symptoms in combat veterans by prazosin: a placebo controlled study’. American Journal of Psychiatry, 160: 371–3.
Reist, C., Kauffmann, C. D., Haier, R. J. et al. (1989) ‘A controlled trial of desipramine in 18 men with posttraumatic stress disorder’. American Journal of Psychiatry, 146: 513–16.
Risse, S. C., Whitters, A., Burke, J. et al. (1990) ‘Severe withdrawal symptoms after discontinuation of alprazolam in eight patients with combat-induced posttraumatic stress disorder’. Journal of Clinical Psychiatry, 51: 206–9.
Schoenfeld, F., Marmar, C. and Neylan, T. (2004) ‘Current concepts in pharmacotherapy for posttraumatic stress disorder’. Psychiatric Services, 55: 519–31.
Seedat, S., Stein, D. J., Ziervogel, C. et al. (2002) ‘Comparison of response to a selective serotonin reuptake inhibitor in children, adolescents, and adults with posttraumatic stress disorder’. Journal of Child and Adolescent Psychopharmacology, 12: 37–46.
Smajkic, A., Weine, S., Duric-Bijedic, Z. et al. (2001) ‘Sertraline, paroxetine, and venlafaxine in refugee posttraumatic stress disorder with depression symptoms’. Journal of Traumatic Stress, 14: 445–52.
Sokolski, K. N., Denson, T. F., Lee, R. T. et al. (2003) ‘Quetiapine for treatment of refractory symptoms of combat-related post-traumatic stress disorder’. Military Medicine, 168: 486–9.
Southwick, S., Paige, S., Morgan, C. et al. (1999) ‘Neurotransmitter alterations in PTSD: catecholamines and serotonin’. Seminars in Clinical Neuropsychiatry, 4: 242–8.
Southwick, S. M., Yehuda, R., Giller, E. et al. (1994) ‘Use of tricyclics and monoamine oxidase inhibitors in the treatment of post traumatic stress disorder: a quantitative review’, in Catecholamine Function in Post-Traumatic Stress Disorder: Emerging Concepts, ed. M. M Murburg. Washington DC: American Psychiatric Press.
Stein, M. B., Kline, N. A. and Matloff, J. L. (2002) ‘Adjunctive olanzapine for SSRI-resistant combat-related PTSD: a double-blind, placebo-controlled study’. American Journal of Psychiatry, 159: 1777–9.
Vaiva, G., Docrocq, F., Jezequel, K. et al. (1994) ‘Immediate treatment with proparanolol decreases posttraumatic stress disorder two months after trauma’. Biological Psychiatry, 54: 947–9.
Van der Kolk, B. A. (1991) ‘Psychopharmacological issues in posttraumatic stress disorder’. American Journal of Psychiatry, 148: 1086–7.
Van der Kolk, B. A. Dreyfuss, D., Michaels, M. et al. (1994) ‘Fluoxetine in post-traumatic stress disorder’. Journal of Clinical Psychiatry, 55: 517–22.
Wang, S., Mason, J., Southwick, S. et al. (1995) ‘Relationships between thyroid hormones and symptoms in combat-related posttraumatic stress disorder’. Psychosomatic Medicine, 57: 398–402.
Yehuda, R., Southwick, S. M., Krystal, J. H. et al. (1993) ‘Enhanced suppression of cortisol following dexamethasone administration in posttraumatic stress disorder’. American Journal of Psychiatry, 150: 83–6.
Zohar, J., Amital, D., Miodownik, C. et al. (2002) ‘Double-blind placebo-controlled pilot study of sertraline in military veterans with posttraumatic stress disorder’. Journal of Clinical Psychopharmacology, 22: 190–5.
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© 2007 Iyad Khreis and Rula Khreis
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Khreis, I., Khreis, R. (2007). Responding to Traumatized Children: a Psychopharmacological Focused Treatment Approach. In: Hosin, A.A. (eds) Responses to Traumatized Children. Palgrave Macmillan, London. https://doi.org/10.1057/9780230625808_7
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DOI: https://doi.org/10.1057/9780230625808_7
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