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Mobilising Flu: The Medical Research Council and the Genesis of British Virus Research

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Modern Flu

Part of the book series: Medicine and Biomedical Sciences in Modern History ((MBSMH))

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Abstract

Contrary to the idea that the 1918–1919 pandemic was ‘forgotten’, this chapter shows how it was used by the British Medical Research Council (MRC) in efforts to scientifically modernise approaches to influenza and other infectious diseases through the development of experimental pathology. At the core of this agenda was a new ‘scheme’ of virus research, established in 1922 to establish ways to determine the role of viruses in diseases that had stymied bacteriology. The pandemic was pivotal. The inability of bacteriologists to settle the aetiology of influenza, coupled with investigations during the pandemic into the possible role of a ‘filterable virus’, served as a rationale for constructing virus research as new medical scientific field. The National Institute of Medical Research (NIMR) was positioned as the hub of the virus scheme, with innovations in experimental pathology at its foundation. By translating the pandemic into a crucial matter for modern medical science and the state, the MRC ensured that influenza figured centrally in the making of virus research as a new field and of virus diseases as a new class of medical problem that were shown to be major factors in the health of nation and empire. A defining characteristic of medical virus research in general, and the NIMR approach in particular, was the essential role of research animals as proxies for studying human diseases. This characteristic required a strongly comparative approach to virus diseases that involved working across species. Despite limited initial success with this approach with influenza, the MRC scheme illustrates how memories and experiences of the pandemic were kept alive and mobilised for the transformation of British medical science in the interwar period.

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Notes

  1. 1.

    NA FD1/1279 Research into Diseases Probably Caused by Filterable Viruses, 3 May 1922 (Hereafter, ‘Virus research’).

  2. 2.

    Medical Research Council, Report of the Medical Research Council for the Year 1921–1922 Report of the Medical Research Council (London: HMSO, 1923), 12.

  3. 3.

    Ibid., 12.

  4. 4.

    Robert E. Kohler, From Medical Chemistry to Biochemistry: The Making of a Biomedical Discipline (Cambridge: Cambridge University Press, 1983), 71–93.

  5. 5.

    Andrew Hull, ‘Teamwork, Clinical Research, and the Development of Scientific Medicines in Interwar Britain: The “Glasgow School” Revisited’, Bulletin of the History of Medicine, 81 (2007), 569–593; Robert E. Kohler, ‘Walter Fletcher, F.G. Hopkins, and the Dunn Institute of Biochemistry: A Case Study in the Patronage of Science’, ISIS, 69 (1978), 331–355; Sturdy and Cooter, ‘Science, Scientific Management, and the Transformation of Medicine in Britain c. 1870–1950’, 421–466.

  6. 6.

    Donald Fisher, ‘The Rockefeller Foundation and the Development of Scientific Medicine in Britain’, Minerva, 16 (1978), 26.

  7. 7.

    Peter Alter, The Reluctant Patron: Science and the State in Britain 1850–1920 (Oxford: Berg, 1987), 127ff.

  8. 8.

    A. Landsborough Thomson, Half a Century of Medical Research. The Programme of the Medical Research Council (UK), Vol. 2, (London: HMSO, 1975), 114.

  9. 9.

    Christopher Lawrence, Rockefeller Money, the Laboratory, and Medicine in Edinburgh, 1919–1930: New Science in an Old Country (Rochester: University of Rochester Press, 2006), 11–23.

  10. 10.

    For the role of scientific experts in interwar Britain, see David Edgerton, Warfare State: Britain, 1920–1970 (Cambridge: Cambridge University Press, 2005), 15–58.

  11. 11.

    For a measure the output, close to three-quarters of the 4,000 publications collected by the London pathologists, David and Robert Thomson, in their comprehensive two-volume annals of influenza research, had been published between 1918 and 1923, mostly on the bacteriological and pathological aspects of the disease. David Thomson and Robert Thomson R. ‘Influenza’, Annals of the Pickett-Thomson Research Laboratory, Parts I & 2 (London: Bailliere, Tindall and Cox, 1933, 1934), v.

  12. 12.

    NA MH 123/498 Relations between the Ministry of Health and the Medical Research Council, 12 February 1924.

  13. 13.

    For recent challenges to the idea that the pandemic was ‘forgotten’ see Samuel K. Cohn Jr. Epidemics: Hate and Compassion from the Plague of Athens to AIDS (Oxford: Oxford University Press, 2018), 408–424; Elsytt W. Jones, ‘Recollecting Influenza: Form, remembrance, and interpretation in Canada’s pandemic’, In M. Bresalier (Ed.), One Hundred Years of Influenza: Afterlives of the 1918–19 Pandemic (London: Routledge, Forthcoming).

  14. 14.

    Joan Austoker, ‘Walter Morley Fletcher and the Origins of a Basic Biomedical Research Policy’, In J. Austoker, & L. Bryder (Eds.), Historical Perspectives on the Role of the MRC: Essays in the History of the MRC of the United Kingdom and its Predecessor, the Medical Research Committee, 1913–1953 (Oxford: Oxford University Press, 1989), 24; Linda Bryder, ‘Public Health Research and the MRC’, In Historical Perspectives on the Role of the MRC, 59–81.

  15. 15.

    For Newman, see Steve Sturdy, ‘From Hippocrates to State Medicine: George Newman on the early Policy of the Ministry of Health’, In George Weisz and Christopher Lawrence (Eds.), Greater than the Parts: Holism in Inter-war Medicine (Oxford: Oxford University Press, 1998), 112–134. For Newman’s conflicts with the MRC, see Linda Bryder, ‘Public Health Research and the MRC’, In Historical Perspectives on the Role of the MRC, 59–81.

  16. 16.

    Lawrence, Rockefeller Money, 11–62; D. Cox-Maksimov, ‘The Making of the Clinical Trial in Britain, 1910–1945: Expertise, the State and the Public’, Ph.D. Thesis. Department of History and Philosophy of Science, University of Cambridge, 1998.

  17. 17.

    Ministry of Health, Report on the Pandemic of Influenza, 1918–19 Reports on Public Health and Medical Subjects, No. 4, (London: HMSO, 1920).

  18. 18.

    Sturdy, ‘From Hippocrates to State Medicine’, 115.

  19. 19.

    For Greenwood, see Olga Amsterdamska, ‘Standardizing Epidemics: Infection, Inheritance and Environment in Prewar Experimental Epidemiology’, In Jean-Paul Gaudillière and Ilana Löwy (Eds.), Heredity and Infection: Historical Essays on Disease Transmission in the Twentieth Century (London: Routledge, 2001), 138; and John R. Matthews, Quantification and the Quest for Medical Certainty (Princeton: Princeton University Press, 1995).

  20. 20.

    J. Andrew Mendelsohn, ‘From Eradication to Equilbrium: How Epidemics Became Complex after World War I’, In Greater than the Parts, 303–331; J. Andrew Mendelsohn, ‘Medicine and the Making of Bodily Inequality in Twentieth Century Europe’, In Heredity and Infection, 21–80.

  21. 21.

    Olga Amsterdamska, ‘Demarcating Epidemiology’, Science, Technology, & Human Values, 1 (2005), 17–51.

  22. 22.

    For Bulloch’s association, see Mendelsohn, ‘From Eradication to Equilibrium’, 309–310.

  23. 23.

    Clifford Allchin Gill, The Genesis of Epidemics and Natural History of Disease (London: Bailliere, Tindall and Cox, 1928).

  24. 24.

    For holism in British medicine, see Christopher Lawrence, ‘Edward Jenner’s Jockey Boots and the Great Tradition in English Medicine, 1918–1939’, In Christopher Lawrence and Anna K. Mayer (Eds.), Regenerating England: Science, Medicine and Culture in Inter-War Britain (Amsterdam: Rodopi, 2000), 45–66.

  25. 25.

    Crookshank, Influenza: Essays by Several Authors; William H. Hamer, The Relationship between Influenza, Cerebrospinal Fever, and Poliomyelitis. Appendix to the Report of the County Medical Officer of Health and School Medical Officer for the Year 1918 (London: County Hall, 1922); William H. Hamer, Report on Influenza by the County Medical Officer of Health (London: County Hall, 1919); W.H. Hamer, ‘The Influenzal Constitution’, Proceedings of the Royal Society of Medicine, 20, (1927), 1349–1368.

  26. 26.

    Mendelsohn, ‘From Eradication to Equilibrium’; 311–313; and Mendelsohn, ‘Medicine and the Making of Bodily Inequality in Twentieth Century Europe’, 21–80.

  27. 27.

    Ministry of Health, Report on the Pandemic of Influenza, 1918–19, 29.

  28. 28.

    Ministry of Health, Report on the Pandemic of Influenza, xvii.

  29. 29.

    Ministry of Health, Report on the Pandemic of Influenza, xxi.

  30. 30.

    Tomkins, ‘Britain and the Influenza Epidemic’, 105.

  31. 31.

    A number of historical studies have shown that governments and local authorities which prioritised nursing care reduced mortality rates among their populations. See Nancy Bristow, American Pandemic: The Lost Worlds of the 1918 Influenza Epidemic (Oxford: Oxford University Press, 2012), 122–151; Sandra Opdycke, ‘A Caregiver’s Nightmare: Trying to Treat Influenza’, In idem., The Influenza Epidemic of 1918: America’s Experience in a Global Health Crisis (London: Routledge 2014), 63–85; A. Keeling, ‘“Alert to the Necessities of the Emergency”: U.S. Nursing During the 1918 Influenza Pandemic’. Public Health Reports, Suppl 3.125 (2010), 105–12. G. Rice and L. Bryder, Black November: The 1918 influenza Epidemic in New Zealand (Wellington, N.Z.: Allen & Unwin, 1988).

  32. 32.

    NA FD1/546 Summary of Influenza Measures, 9 January 1920. Ministry of Health, Influenza: Hints and Precautions (London: HMSO, 1920).

  33. 33.

    Ministry of Health, Influenza: Hints and Precautions (London: HMSO, 1920).

  34. 34.

    Ministry of Health, Influenza: Hints and Precautions (London: HMSO, 1920).

  35. 35.

    Ministry of Health, Influenza Vaccine: Instructions to Medical Officers of Health, Signed by George Newman (London: HMSO, 1919); ‘Prevention of Influenza’, Lancet, (3 January 1920), 41; ‘Preparations for an Influenza Epidemic’ Lancet, (31 January 1920), 270–271.

  36. 36.

    Ministry of Health, Report on the Pandemic of Influenza, xxi; NA FD1/546 Summary of Influenza Measures, 9 January 1920.

  37. 37.

    NA FD1/535 Influenza Committee Agenda, 3 February 1920.

  38. 38.

    NA MH 113 51 Reports by the Delegate of Great Britain on the Sessions of the Committee of the Office International d’Hygiène Publique, Paris and of the Health Committee of the League of Nations (Reports 1–12), 1920.

  39. 39.

    Ministry of Health Report on the Pandemic of Influenza, xx.

  40. 40.

    NA FD1/545 Cooperation between ‘field’ and laboratory, Letters sent to researchers, physicians and Ministry of Health Officials, 31 January 1920; NA FD1/546 Influenza epidemic: reports and correspondence; Medical Research Council, Annual Report of the Medical Research Council, 1919–1920 (London: HMSO, 1920), 49.

  41. 41.

    NA FD1/545 Notes of an informal conference on the requirements of research workers in the event of an influenza epidemic, 6 February 1920. In attendance were: Fletcher, Leishman (Chair), William Bulloch (University of London), Thomas Carnwath (Ministry of Health), S.L. Cummins (RAMC), Douglas (MRC/NIMR), Fildes (London Hospital), Alexander Fleming (St. Mary’s Hospital), F. Griffiths (Ministry of Health), McIntosh (Middlesex Hospital), Twort (Brown Institution).

  42. 42.

    NA FD1/545 Cooperation between ‘field’ and laboratory.

  43. 43.

    NA FD1/545 Cooperation between ‘field’ and laboratory.

  44. 44.

    NA FD1/545 Cooperation between ‘field’ and laboratory.

  45. 45.

    Linda Bryder, ‘Public Health Research and the MRC’, 68.

  46. 46.

    Lise Wilkinson, ‘The Development of the Virus Concept as Reflected in Corpora of Studies on Individual Pathogens. 4. Rabies—Two Millennia of Ideas and Conjecture on the Aetiology of a Virus Disease’, Medical History, 21 (1977), 22–24.

  47. 47.

    Sally Smith-Hughes, The Virus: A History of a Concept (London: Heineman, 1977)

  48. 48.

    Lise Wilkinson, ‘Animal Viruses, Veterinary Pathology, and the Formulation of Ideas Concerning Filterable Viruses’, Historia Medicinae Veterinariae, 3 (1978), 1–15.

  49. 49.

    Wilkinson, ‘The Development of the Virus Concept, 4—Rabies’, 30.

  50. 50.

    A. Waterson and L. Wilkinson, An Introduction to the History of Virology (Cambridge: Cambridge University Press, 1978), 30–33.

  51. 51.

    Ilana Löwy, Virus, Moustiques et Modernite: La Fievre Jaune au Brasail entre Science et Politique (Paris: Editions des archives contemporaines, 2001).

  52. 52.

    Anne Hardy, ‘Poliomyelitis and the Neurologists: The View from England, 1896–1966’, Bulletin of the History of Medicine, 71 (1997), 249–272; Waterson and Wilkinson, An Introduction to the History of Virology, 50–51.

  53. 53.

    G.W. Corner, The Rockefeller Institute: Origins and Growth, 1901–1953, New York: Rockefeller Institute Press; Ilana Löwy and Patrick Zylberman, ‘Medicine as a Social Instrument: Rockefeller Foundation, 1913–45’, Studies in History and Philosophy of the Biological and Biomedical Sciences, 31 (2000), 365–379.

  54. 54.

    Ton van Helvoort, ‘History of Virus Research in the Twentieth Century: The Problem of Conceptual Continuity’, History of Science, XXXII (1994), 185–235.

  55. 55.

    John McFaydean, ‘The Ultravisible Viruses’, Journal of Comparative Pathology and Therapeutics, XXI (1908), 66.

  56. 56.

    F.W. Twort, ‘The Ultramicroscopic Viruses’, The Journal of State Medicine, 31 (1923), 351–366; T.M. Rivers, ‘Filterable Viruses: A Critical Review’, Journal of Bacteriology, 14 (1927), 217–258; T.M. Rivers, ‘Some General Aspects of Filterable Viruses’, In T.M. Rivers Filterable Viruses (London: Bailliere, Tindall & Cox, 1928), 3–52; T.M. Rivers, ‘Filterable Viruses’, In E.O. Jordan and I.S. Falk (Eds.), The New Knowledge of Bacteriology and Immunology, (Chicago: University of Chicago Press, 1928).

  57. 57.

    For the use of these prefixes, see Ton van Helvoort, ‘History of Virus research in the Twentieth Century: The Problem of Conceptual Continuity’, History of Science, XXXII, (1994), 185–235.

  58. 58.

    Rivers, Filterable Viruses, 6

  59. 59.

    Iain Pattison, John McFadyean, Founder of Modern Veterinary Research (London: JA Allen, 1981).

  60. 60.

    John McFadyean, ‘African Horse Sickness’, Journal of Comparative Pathology and Therapeutics, XIII (1900), 1–20.

  61. 61.

    John McFadyean, ‘The Ultravisible Viruses’, Journal of Comparative Pathology and Therapeutics, XXI (1908), 58–68, 168–175, 232–242.

  62. 62.

    Lise Wilkinson, Animals and Disease: An Introduction to the History of Comparative Medicine (Cambridge: Cambridge University Press, 1992); Rachel Mason Dentinger and Abigail Woods. ‘Introduction to Working Across Species.’ History and Philosophy of the Life Sciences 40.2 (2018), 30–41.

  63. 63.

    William F. Bynum, ‘“C’est une Malade!” Animal Models and Concepts of Human Diseases’ Journal of the History of Medicine and Allied Sciences 45 (1990), 397–413; Cheryl Logan, ‘Before there Were Standards: The Role of Test Animals in the Production of Empirical Generality in Physiology’, Journal of the History of Biology 35 (2002), 329–363; Michael Worboys. ‘Germ Theories of Disease and British Veterinary Medicine, 1860–1890’, Medical History 35 (1991): 308–327; Christoph Gradmann. ‘Robert Koch and the Invention of the Carrier State: Tropical Medicine, Veterinary Infections and Epidemiology around 1900’, Studies in History and Philosophy of Biological and Biomedical Sciences 41 (2010): 232–240.

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    R.D. French, Antivivisection and Medical Science in Victorian Society (Princeton, NJ and London: Princeton University Press, 1975); Paul Elliot, ‘Vivisection and the Emergence Of Experimental Physiology in Nineteenth-century France’, In N. Rupke (Ed.), Vivisection in Historical Perspective (London, Croom Helm, 1987), 48–77; M.A. Finn and J.F. Stark, ‘Medical Science and the Cruelty to Animals Act 1876: A Re-examination of Anti-vivisectionism in Provincial Britain’, Studies in History and Philosophy of Biological & Biomedical Sciences 49 (2015), 12–23.

  65. 65.

    Robert G.W. Kirk, ‘Wanted—Standard Guinea Pigs’: Standardisation and the Experimental Animal Market in Britain ca. 1919–1947, Studies in History and Philosophy of Biological and Biomedical Sciences 39.3 (2008), 280–291.

  66. 66.

    Harriet Chick, M. Hume and M. MacFarlane, War on Disease: A History of the Lister Institute (London: A. Deutsch, 1971), 187ff; 212ff.

  67. 67.

    Paul Fildes, ‘Frederick William Twort, 1877–1950’, Obituary Notices of Fellows of The Royal Society, 7 (1951), 507–517; Ton van Helvoort, ‘The Construction of Bacteriophage as Bacterial Virus: Linking Endogenous and Exogenous Thought Styles’, Journal of the History of Biology, 27 (1994), 91–139.

  68. 68.

    F.W. Twort, ‘An Investigation of the Nature of Ultramicroscopic Viruses’, Lancet, (4 December 1915), 1241–1243.

  69. 69.

    Ton van Helvoort, ‘Bacteriology and Physiological Research Styles in the Early Controversy on the Nature of the Bacteriophage Phenomenon’, Medical History, 36 (1992), 243–270; William C. Summers, Felix d'Herelle and the Origins of Molecular Biology (New Haven; London: Yale University Press, 1999).

  70. 70.

    A. Twort, In Focus, Out of Step: A Biography of Frederick William Twort F.R.S., 1877–1950 (Dover, NH: A. Sutton, 1993).

  71. 71.

    Scott H. Podolsky, ‘The Role of the Virus in Origin-of-Life Theorizing’, Journal of the History of Biology, 29 (1996) 87; Lise Wilkinson, ‘Review: In Focus, Out of Step: A Biography of Frederick William Twort, F.R.S.’ Medical History, 38 (1994), 340–341.

  72. 72.

    For a brief overview of these connections, see Barbara C. Canavan, ‘Collaboration Across the Pond: Influenza Virus Research’, Rockefeller Archive Center Research Reports Online, 2014. Accessed 15 October 2019. http://rockarch.org/publications/resrep/canavan.pdf.

  73. 73.

    NA FD1/533 Fletcher to Fildes, 28 October 1918. Medical Research Committee, Studies of Influenza in Hospitals of the British Armies in France, 1918 (London: HMSO, 1919).

  74. 74.

    Wilhelm Kruse, ‘Die Erreger v. Husten und Schnupfen’, Münchener medizinische Wochenschrift, 65 (1914), 1228.

  75. 75.

    Rene Dujarric de la Riviere, ‘La grippe est-elle une maladie a virus filtrant?’ Comptes Rendus de l'Academie des Sciences. Paris, 167 (1918), 606–607; Charles Nicolle and Charles Lebailly, ‘Quelques notions experimentales sur le virus de la grippe’, Comptes Rendus de l’Academie des Sciences Paris, 167 (1918), 607–610. For a brief discussion of de la Riviere’s work, see Ilana Löwy, ‘Influenza and Historians: A Difficult Past’ In T. Giles-Vernick and S. Craddock (Eds.), Influenza and Public Health: Learning from Past Pandemics (London and Washington: Earthscan, 2010), 92.

  76. 76.

    C. Nicolle and C. Lebailly, ‘Quelques notions experimentales sur le virus de la grippe’, Comptes Rendus de l’Academie des Sciences Paris, 167 (1918), 607–610.

  77. 77.

    Op.cit., D. Thomson and R. Thomson, ‘Influenza (Part I)’, Annals of the Pickett-Thomson Research Laboratory, (London: Bailliere, Tindall and Cox, 1933), 607.

  78. 78.

    H.G. Gibson, F.B. Bowman and J.I. Connor, ‘The Etiology of Influenza: A Filterable Virus as the Cause’. In Medical Research Committee, Studies of Influenza in Hospitals of the British Armies in France, 1918 (London: HMSO, 1919), 19–36.

  79. 79.

    S.L. Cummins, ‘Major H.G. Gibson’, British Medical Journal, 8 March (1919), 294–295. Gibson had joined the RAMC in 1907, trained in bacteriology and developed an anti dysenteric serum-vaccine at the College’s Vaccine Department in 1917, after which he joined the AMS an assistant advisor in pathology.

  80. 80.

    NA FD1/529 MRC, Influenza Research by Colonel Cummins with British Forces in France. S.L. Cummins, Studies of Influenza in Hospitals of the British Armies in France, Medical Research Committee, Special Report Series No. 36 (London: HMSO, 1919); Gibson, Bowman and Connor, ‘The Etiology of Influenza’, 645–646.

  81. 81.

    Gibson, Bowman and Connor, ‘The Etiology of Influenza’, 646.

  82. 82.

    Gibson, Bowman and Connor, ‘The Etiology of Influenza’, 24.

  83. 83.

    F.W. Andrewes, ‘The Bacteriology of Influenza’, In Report on the Pandemic of Influenza, 1918–1919, 110–125.

  84. 84.

    J.A. Arkwright, ‘A Criticism of Certain Recent Claims to Have Discovered and Cultivated the Filter-passing Virus of Trench Fever and of Influenza’, BMJ (23 August 1919), 233–235; W.J. Bishop, ‘Arkwright, Sir Joseph Arthur (1864–1944)’, Oxford Dictionary of National Biography. Retrieved 10 December 2019, www.oxforddnb.com/view/10.1093/ref:odnb/9780198614128.001.0001/odnb-9780198614128-e-30442.

  85. 85.

    John Rose Bradford ‘Notes on Dr. Arkwright’s Article’, BMJ (23 August 1919), 236–237.

  86. 86.

    J.A. Wilson, ‘Notes on Dr. Arkwright’s Article’, BMJ (23 August 1919), 237.

  87. 87.

    Fildes and McIntosh, ‘The Aetiology of Influenza’, 159–174.

  88. 88.

    Fildes and McIntosh, ‘The Aetiology of Influenza’, 164.

  89. 89.

    H.B. Maitland, M.L. Cowan and H.K. Detweiler, The Aetiology of Epidemic Influenza: Experiments in Search of a Filter-passing Virus (Toronto: The University Library [Toronto], 1921).

  90. 90.

    Fildes and McIntosh, ‘The Aetiology of Influenza', 159.

  91. 91.

    R. Pfeiffer, ‘Das Influenzaproblem’ [The influenza problem] Ergebnisse der Hygiene, Bakteriologie, Immunitätsforschung und experimentellen Therapie 5 (1922), 1–18.

  92. 92.

    ‘The Pathology of Influenza’, Lancet, (31 March 1923), 665–666; J.G. Adami ‘Influenza’, 413–466.

  93. 93.

    Francis G. Blake and Russell L. Cecil, ‘Studies in Experimental Pneumonia. IX. Production in Monkeys of an Acute Respiratory Disease Resembling Influenza by Inoculation with Bacillus Influenzae’ Journal of Experimental Medicine 32.6 (1920), 691–717; ibid., ‘Studies in Experimental Pneumonia. X. Pathology of Experimental Influenza and of the Bacillus Influenzae Pneumonia in Monkeys’, Journal of Experimental Medicine 32.6 (1920), 719–744.

  94. 94.

    J.W. Edington, ‘An Investigation into the Causal Organism of Influenza’, Lancet, (14 August 1920), 340.

  95. 95.

    W.M. Scott, ‘Observations on the Distribution and Serological Characters of Influenza Bacilli’, Ministry of Health Reports on Public Health and Medical Subjects, No. 13 (London: HSMO 1922), 76.

  96. 96.

    C.F.T. East, ‘Pneumococcal Influenza’, BMJ, 2 (1922), 1117.

  97. 97.

    R. Donaldson, ‘The Bacteriology of Influenza—With Special Reference to Pfeiffer’s Bacillus’, In Influenza: Essays by Several Authors, 139–213.

  98. 98.

    H.B. Maitland and G.C. Cameron, ‘The Aetiology of Epidemic Influenza: A Critical Review’, Canadian Medical Association Journal, XI, (1921), 492.

  99. 99.

    Donaldson, 'The Bacteriology of Influenza’, 158.

  100. 100.

    For a discussion of Donaldson’s analysis of Pfeiffer’s bacillus, see Tan von Helvoort, ‘A Bacteriological Paradigm in Influenza Research in the First Half of the Twentieth Century', History and Philosophy of the Life Sciences, 15 (1993), 8–10.

  101. 101.

    NA MH/55 57 Memorandum on Influenza (Revised Edition), 1927; MH/55 57 Influenza and Common Colds, 1920.

  102. 102.

    W.M. Scott, ‘The Influenza Group of Bacteria’, In P. Fildes, P. & J.C.G. Ledingham (Eds.), A System of Bacteriology in Relation to Medicine (London: HSMO, 1929), 326–394.

  103. 103.

    Scott, ‘The Influenza Group of Bacteria’ and Scott, ‘Observations on the Distribution and Serological Characters of Influenza Bacilli’, 76–89.

  104. 104.

    Ministry of Health, Memorandum on Influenza, 1927 (revised 1929).

  105. 105.

    A. Fleming, ‘On Some Simply Prepared Culture Media for B. Influenzae, with a note regarding the agglutination reaction of sera from patients suffering from influenza to this bacillus’, Lancet (25 January 1919), 138–39; A. Fleming and F.J. Clemenger, ‘An Experimental Research into the Specificity of the Agglutinins Produced by Pfeiffer’s bacillus.” Lancet (15 November 1919), 869–871.

  106. 106.

    Wei Chen, ‘The Laboratory as Business: Sir Almorth Wright’s Vaccine Programme and the Construction of Penicillin’, In A. Cunningham and P. Williams (Eds.), The Laboratory Revolution in Medicine (Cambridge: Cambridge University Press, 1992), 277.

  107. 107.

    A. Fleming, ‘On the Antibacterial Action of Cultures of a Penicillum, with special Reference to Their Use in the Isolation of B. influenzae’, British Journal of Experimental Pathology, X (1929), 226–234; W. Chen, ‘The Laboratory as Business’, 287–292.

  108. 108.

    W. Chen, ‘The Laboratory as Business’, 245–292.

  109. 109.

    Austoker, ‘Walter Morley Fletcher and the Origins of a Basic Biomedical Research Policy’, 22–33.

  110. 110.

    Medical Research Council, Report of the Medical Research Council for the Year 1922–1923 (London: HMSO, 1924), 14–22.

  111. 111.

    Medical Research Council, Report of the Medical Research Council for the Year 1919–1920 (London: HMSO, 1921), 1–12.

  112. 112.

    R.E. Kohler, ‘Bacterial Physiology: The Medical Context’, Bulletin of the History of Medicine, 59 (1985), 55–56.

  113. 113.

    Alter, The Reluctant Patron, pp. 127ff.

  114. 114.

    Steve Sturdy, ‘The Political Economy of Scientific Medicine: Science, Education and the Transformation of Medical Practice in Sheffield, 1890–1922’, Medical History, 36 (1992), 125–159.

  115. 115.

    Medical Research Council, Report of the Medical Research Council for the Year 1922–1923, 16; Mark Weatherall, Gentlemen, Scientists, and Doctors: Medicine at Cambridge, 1800–1940 (Rochester, NY: Boydell Press 2000), 169–172.

  116. 116.

    Austoker and Bryder, ‘The National Institute for Medical Research’, 39–52; C.H. Harrington, ‘The Work of the National Institute for Medical Research’, Proceedings of the Royal Society of London, 136 (1950), 333–349. Thomson, Half a Century of Medical Research, Vol. 2, 110–11.

  117. 117.

    Austoker, ‘Walter Morley Fletcher and the Origins of a Basic Biomedical Research Policy’, 27; Fisher, ‘The Rockefeller Foundation and the Development of Scientific Medicine in Britain'; L. Wilkinson, ‘Burgeoning Visions of Global Public Health: The Rockefeller Foundation, the London School of Hygiene and Tropical Medicine, and the ‘Hookworm Connection’, Studies in History and Philosophy of Biological and Biomedical Sciences, 31 (2000), 397–407.

  118. 118.

    Alter, The Reluctant Patron, p. 127.

  119. 119.

    For teamwork as an organisational principle in interwar British medicine, see Andrew Hull, ‘Teamwork, Clinical Research, and the Development of Scientific Medicines in Interwar Britain: The “Glasgow School” Revisited’, Bulletin of the History of Medicine, 81 (2007), 569–593; Roger Cooter, ‘Keywords in the History of Medicine: “Teamwork”’, Lancet, 363 (2004), 1245; Steve Sturdy, ‘Scientific Method for Medical Practitioners: The Case Method of Teaching Pathology in Early Twentieth-Century Edinburgh’, Bulletin of the History of Medicine, 81 (2007), 760–792.

  120. 120.

    Medical Research Council, Report of the Medical Research Council for the Year 1921–1922 (London: HMSO, 1923), 23.

  121. 121.

    Austoker and Bryder, ‘The National Institute for Medical Research’, 35–38; Thomson, Half a Century of Medical Research, Vol. 1. 108–109.

  122. 122.

    It is likely that Wright’s clashes with the War Office and MRC over the treatment of war wounds, and his own commercial interests, lead to a mutual agreement to withdraw the offer. A.L. Thomson Half a Century of Medical Research, Vol. 1. Origins and policy of the Medical Research Council (UK) (London: MRC, 1973) 112, 115–116.

  123. 123.

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    The first editorial board included Fildes, McIntosh, J.A. Murray, and W.E. Gye.

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    Mervyn H. Gordon, ‘On Experimental Investigations in Relation to Mumps or Epidemic Parotitis, Reports of Local Government Board, Public Health, New Series, 96 (London: Local Government Board, 1914).

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    P. Olitsky and F.L. Gates, ‘Experimental Study of the Nasopharyngeal Secretions from Influenza patients: Preliminary Report’, Journal of the American Medical Association, 74 (1920), 1497–1499.

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    Hideyo Noguchi, ‘A Method for the Pure Cultivation of Pathogenic Treponema Pallidum (Spirochata Pallida)’, Journal of Experimental Medicine, 14 (August 1911), 99–108.

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    Peter Olitsky and F.L. Gates, ‘Methods for the Isolation of Filter-passing Anaerobic Organisms: From Nasopharyngeal Secretions’, Journal of the American Medical Association, 78 (April 1922), 1020–1022.

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    Mervyn H. Gordon, ‘The Filter Passer of Influenza’, Journal of the Royal Army Medical Corps, 39 (1 July 1922), 6.

  140. 140.

    Gordon, ‘The Filter Passer of Influenza’, 7, 10.

  141. 141.

    NA, FD1/1297 Gordon to Thomson, 11 January 1922; Gordon to Fletcher, 3 February 1922.

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    Gordon, ‘The Filter Passer of Influenza’, 9.

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    M.H. Gordon, ‘The Filter Passer of Influenza’, Journal of the Royal Army Medical Corps, 39, (1922), 400.

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    Creager, Life of a Virus, 19, 32–38.

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    F.W. Twort, ‘An Investigation of the Nature of Ultramicroscopic Viruses’, Lancet, (4 December 1915), 1241–1243.

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    Creager Life of a Virus, 32–33.

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  149. 149.

    Gordon, 'The Filter Passer of Influenza', 11.

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    Medical Research Council, Report of the Medical Research Council for the Year 1922–1923, 11

  151. 151.

    A.L. Thomson, Half a Century of Medical Research. Origins and Policy of the Medical Research Council (UK), Vol. 1, (London: HMSO, 1973), 120–123; A.L. Thomson, Half a Century of Medical Research. The Programme of the Medical Research Council (UK), Vol. 2, (London: HMSO, 1975), 114–129.

  152. 152.

    NA FD1/1279 Virus research; Medical Research Council, Report of the Medical Research Council for the Year 1921–1922, 11–13.

  153. 153.

    NA FD1/1279 ‘Virus research’, 3 May 1922.

  154. 154.

    H.H. Dale, ‘Patrick Playfair Laidlaw’, Obituary Notices of Fellows of The Royal Society, 3 (1941), 430.

  155. 155.

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  156. 156.

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  157. 157.

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  158. 158.

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  159. 159.

    NA FD1/1297 Virus research, 3 May 1922.

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  161. 161.

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  162. 162.

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  163. 163.

    NA MH 123/498 Relations between the Ministry of Health and the Medical Research Council, 12 February 1924.

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    Helen Valier and Carsten Timmermann, ‘Clinical Trials and the Reorganization of Medical Research in post-Second World War Britain’, Medical History, 52 (2008), 497.

  165. 165.

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    Creager, Life of a Virus, 33.

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    Creager and Gaudillière, ‘Experimental Arrangements and Technologies of Visualisation’; Daniel J. Kevles and Gerald L. Geison, ‘The Experimental Life Sciences in the Twentieth Century’, Osiris, 10 (1995), 108–120.

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Bresalier, M. (2023). Mobilising Flu: The Medical Research Council and the Genesis of British Virus Research. In: Modern Flu. Medicine and Biomedical Sciences in Modern History. Palgrave Macmillan, London. https://doi.org/10.1057/978-1-137-33954-6_5

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