New Approaches to Treating Cannabis Dependence: From Neuroscience to Practice
The existence of cannabis dependence has been questioned for a long time (Murray et al., 2007). This debate has partly stemmed from an outdated view on substance use disorders (SUDs; Leshner, 1997), which measured the relative harm of substances of abuse through the severity of physical dependence (tolerance and withdrawal). In 1964, the World Health Organization recognized psychological dependence as the driving force behind SUDs, rather than physical dependence (Eddy et al., 1965). However, the minimal withdrawal symptoms associated with chronic cannabis use still supported the consensus that cannabis was not addictive (Murray et al., 2007).
KeywordsAlcohol Dependence Cognitive Control Attentional Bias Fatty Acid Amide Hydrolase Cannabis User
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- Boggio, P. S., Zaghi, S., Villani, A. B., Fecteau, S., Pascual-Leone, A., & Fregni, F. (2010). ‘Modulation of risk-taking in marijuana users by transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC)’, Drug and Alcohol Dependence, 112, 220–5.CrossRefPubMedGoogle Scholar
- Cornelius, J. R., Chung, T., Martin, C., Wood, D. S., & Clark, D. B. (2008). ‘Cannabis withdrawal is common among treatment-seeking adolescents with cannabis dependence and major depression, and is associated with rapid relapse to dependence’, Addictive Behaviors, 33, 1500–5.CrossRefPubMedPubMedCentralGoogle Scholar
- Cousijn, J., Wiers, R. W., Ridderinkhof, K. R., van den Brink, W, Veltman, D. J., & Goudriaan, A. E. (2013a). ‘Effect of baseline cannabis use and working-memory network function on changes in cannabis use in heavy cannabis users: A prospective fMRI study’, Human Brain Mapping, 35(5), 2470–82.CrossRefPubMedGoogle Scholar
- Cousijn, J., Wiers, R. W., Ridderinkhof, K. R., van den Brink, W., Veltman, D. J., Porrino, L. J., & Goudriaan, A. E. (2013b). ‘Individual differences in decision making and reward processing predict changes in cannabis use: A prospective functional magnetic resonance imaging study’, Addiction Biology, 6, 1013–23.CrossRefGoogle Scholar
- Dekker, N., Smeerdijk, A. M., Wiers, R. W, Duits, J. H., van Gelder, G., Houben, K., … de Haan, L. (2010). ‘Implicit and explicit affective associations towards cannabis use in patients with recent-onset schizophrenia and healthy controls’, Psychological Medicine, 40, 1325–36.CrossRefPubMedGoogle Scholar
- Florez-Salamanca, L., Secades-Villa, R., Budney A. J., Garcia-Rodriguez, O., Wang, S., & Blanco, C. (2013). ‘Probability and predictors of cannabis use disorders relapse: Results of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC)’, Drug and Alcohol Dependence, 132, 127–33.CrossRefPubMedPubMedCentralGoogle Scholar
- Gore, R., & Earleywine, M. (2007). ‘Marijuana’s perceived addictiveness: A survey of clinicians and researchers’. In M. Earleywine (Ed.), Pot politics: Marijuana and the costs of prohibition. (New York, NY: Oxford University Press).Google Scholar
- Heyman, G. M. (2009). Addiction: A disorder of choice. (Boston, MA: Harvard University Press).Google Scholar
- Shafa, R. (2009). ‘COMT-inhibitors may be a promising tool in treatment of marijuana addiction trials’, The American Journal on Addictions, 18, 322.Google Scholar
- Wiers, R. W., Bartholow, B. D., van den Wildenberg, E., Thush, C., Engels, R. C., Sher, K. J., … Stacy, A. W. (2007). ‘Automatic and controlled processes and the development of addictive behaviors in adolescents: A review and a model’, Pharmacology, Biochemistry, and Behavior, 86, 263–83.CrossRefPubMedGoogle Scholar
- Wiers, R. W., Gladwin, T. E., Hofmann, W., Salemink, E., & Ridderinkhof, K. R. (2013). ‘Cognitive bias modification and cognitive control training in addiction and related psychopathology: Mechanisms, clinical perspectives, and ways forward’, Clinical Psychological Science, 1, 192–212.CrossRefGoogle Scholar