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New Approaches to Treating Cannabis Dependence: From Neuroscience to Practice

  • Janna Cousijn
  • Francesca Filbey

Abstract

The existence of cannabis dependence has been questioned for a long time (Murray et al., 2007). This debate has partly stemmed from an outdated view on substance use disorders (SUDs; Leshner, 1997), which measured the relative harm of substances of abuse through the severity of physical dependence (tolerance and withdrawal). In 1964, the World Health Organization recognized psychological dependence as the driving force behind SUDs, rather than physical dependence (Eddy et al., 1965). However, the minimal withdrawal symptoms associated with chronic cannabis use still supported the consensus that cannabis was not addictive (Murray et al., 2007).

Keywords

Alcohol Dependence Cognitive Control Attentional Bias Fatty Acid Amide Hydrolase Cannabis User 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Agosti, V., & Levin, F. R. (2004). ‘Predictors of treatment contact among individuals with cannabis dependence’, The American Journal of Drug and Alcohol Abuse, 30, 121–7.CrossRefPubMedGoogle Scholar
  2. Aracil-Fernandez, A., Almela, P., & Manzanares, J. (2013). ‘Pregabalin and topiramate regulate behavioural and brain gene transcription changes induced by spontaneous cannabinoid withdrawal in mice’, Addiction Biology, 18, 252–62.CrossRefPubMedGoogle Scholar
  3. Asmaro, D., Carolan, P. L., & Liotti, M. (2014). ‘Electrophysiological evidence of early attentional bias to drug-related pictures in chronic cannabis users’, Addictive Behaviors, 39, 114–21.CrossRefPubMedGoogle Scholar
  4. Beraha, E. M., Cousijn, J., Hermanides, E., Goudriaan, A. E., & Wiers, R. W. (2013). ‘Implicit associations and explicit expectancies toward cannabis in heavy cannabis users and controls’, Frontiers in Psychiatry, 4, 59.CrossRefPubMedPubMedCentralGoogle Scholar
  5. Bickel, W. K., Yi, R., Landes, R. D., Hill, P. R, & Baxter, C. (2011). ‘Remember the future: Working memory training decreases delay discounting among stimulant addicts’, Biological Psychiatry, 69, 260–5.CrossRefPubMedPubMedCentralGoogle Scholar
  6. Boggio, P. S., Zaghi, S., Villani, A. B., Fecteau, S., Pascual-Leone, A., & Fregni, F. (2010). ‘Modulation of risk-taking in marijuana users by transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC)’, Drug and Alcohol Dependence, 112, 220–5.CrossRefPubMedGoogle Scholar
  7. Budney, A. J., Vandrey R. G., Hughes, J. R., Thostenson, J. D., & Bursac, Z. (2008). ‘Comparison of cannabis and tobacco withdrawal: Severity and contribution to relapse’, Journal of Substance Abuse Treatment, 35, 362–8.CrossRefPubMedPubMedCentralGoogle Scholar
  8. Chauchard, E., Septfons, A., & Chabrol, H. (2013). ‘Motivations for cannabis cessation, coping and adaptation strategies, and perceived benefits: Impact on cannabis use relapse and abstinence’, Encephale, 39, 385–92.CrossRefPubMedGoogle Scholar
  9. Chung, T., Martin, C. S., Cornelius, J. R., & Clark, D. B. (2008). ‘Cannabis withdrawal predicts severity of cannabis involvement at 1-year follow-up among treated adolescents’, Addiction, 103, 787–99.CrossRefPubMedPubMedCentralGoogle Scholar
  10. Clapper, J. R., Mangieri, R. A., & Piomelli, D. (2009). ‘The endocannabinoid system as a target for the treatment of cannabis dependence’, Neuropharmacology, 56 Suppl 1, 235–43.CrossRefPubMedPubMedCentralGoogle Scholar
  11. Cornelius, J. R., Chung, T., Martin, C., Wood, D. S., & Clark, D. B. (2008). ‘Cannabis withdrawal is common among treatment-seeking adolescents with cannabis dependence and major depression, and is associated with rapid relapse to dependence’, Addictive Behaviors, 33, 1500–5.CrossRefPubMedPubMedCentralGoogle Scholar
  12. Cousijn, J. (2012). ‘A joint approach: Brain structure and function in heavy cannabis users and their relationship with future use’ (Doctoral Dissertation). Retrieved from http://dare.uva.nl/en/record/431855Google Scholar
  13. Cousijn, J., Goudriaan, A. E., Ridderinkhof, K. R., van den Brink, W., Veltman, D. J., & Wiers, R. W. (2012). ‘Approach-bias predicts development of cannabis problem severity in heavy cannabis users: Results from a prospective fMRI study’, PLoS one, 7, e42394.CrossRefGoogle Scholar
  14. Cousijn, J., Goudriaan, A. E., & Wiers, R. W. (2011). ‘Reaching out towards cannabis: Approach-bias in heavy cannabis users predicts changes in cannabis use’, Addiction, 106, 1667–74.CrossRefPubMedPubMedCentralGoogle Scholar
  15. Cousijn, J., Watson, P., Koenders, L., Vingerhoets, W A., Goudriaan, A. E., & Wiers, R. W. (2013). ‘Cannabis dependence, cognitive control and attentional bias for cannabis words’, Addictive Behaviors, 38, 2825–32.CrossRefPubMedGoogle Scholar
  16. Cousijn, J., Wiers, R. W., Ridderinkhof, K. R., van den Brink, W, Veltman, D. J., & Goudriaan, A. E. (2013a). ‘Effect of baseline cannabis use and working-memory network function on changes in cannabis use in heavy cannabis users: A prospective fMRI study’, Human Brain Mapping, 35(5), 2470–82.CrossRefPubMedGoogle Scholar
  17. Cousijn, J., Wiers, R. W., Ridderinkhof, K. R., van den Brink, W., Veltman, D. J., Porrino, L. J., & Goudriaan, A. E. (2013b). ‘Individual differences in decision making and reward processing predict changes in cannabis use: A prospective functional magnetic resonance imaging study’, Addiction Biology, 6, 1013–23.CrossRefGoogle Scholar
  18. Dekker, N., Smeerdijk, A. M., Wiers, R. W, Duits, J. H., van Gelder, G., Houben, K., … de Haan, L. (2010). ‘Implicit and explicit affective associations towards cannabis use in patients with recent-onset schizophrenia and healthy controls’, Psychological Medicine, 40, 1325–36.CrossRefPubMedGoogle Scholar
  19. Eberl, C., Wiers, R. W., Pawelczack, S., Rinck, M., Becker, E. S., & Lindenmeyer, J. (2013). ‘Approach bias modification in alcohol dependence: Do clinical effects replicate and for whom does it work best?’, Developmental Cognitive Neuroscience, 4, 38–51.CrossRefPubMedGoogle Scholar
  20. Eddy, N. B., Halbach, H., Isbell, H., & Seevers, M. H. (1965). ‘Drug dependence: Its significance and characteristics’, Bulletin of the World Health Organization, 32, 721–33.PubMedPubMedCentralGoogle Scholar
  21. Everitt, B. J., & Robbins, T. W. (2005). ‘Neural systems of reinforcement for drug addiction: From actions to habits to compulsion’, Nature Neuroscience, 8, 1481–9.CrossRefPubMedGoogle Scholar
  22. Fadardi, J. S., & Cox, W. M. (2009). ‘Reversing the sequence: Reducing alcohol consumption by overcoming alcohol attentional bias’, Drug and Alcohol Dependence, 101, 137–45.CrossRefPubMedGoogle Scholar
  23. Fernandez-Serrano, M. J., Perez-Garcia, M., & Verdejo-Garcia, A. (2011). ‘What are the specific vs. generalized effects of drugs of abuse on neuropsychological performance?’, Neuroscience and Biobehavioral reviews, 35, 377–406.CrossRefPubMedGoogle Scholar
  24. Field, M., Eastwood, B., Bradley, B. P., & Mogg, K. (2006). ‘Selective processing of cannabis cues in regular cannabis users’, Drug and Alcohol Dependence, 85, 75–82.CrossRefPubMedGoogle Scholar
  25. Florez-Salamanca, L., Secades-Villa, R., Budney A. J., Garcia-Rodriguez, O., Wang, S., & Blanco, C. (2013). ‘Probability and predictors of cannabis use disorders relapse: Results of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC)’, Drug and Alcohol Dependence, 132, 127–33.CrossRefPubMedPubMedCentralGoogle Scholar
  26. Goldstein, R. Z., & Volkow, N. D. (2002). ‘Drug addiction and its underlying neurobiological basis: Neuroimaging evidence for the involvement of the frontal cortex’, The American Journal of Psychiatry, 159, 1642–52.CrossRefPubMedPubMedCentralGoogle Scholar
  27. Gore, R., & Earleywine, M. (2007). ‘Marijuana’s perceived addictiveness: A survey of clinicians and researchers’. In M. Earleywine (Ed.), Pot politics: Marijuana and the costs of prohibition. (New York, NY: Oxford University Press).Google Scholar
  28. Gray, K. M., Larowe, S. D., Watson, N. L., & Carpenter, M.J. (2011). ‘Reactivity to in vivo marijuana cues among cannabis-dependent adolescents’, Addictive Behaviors, 36, 140–3.CrossRefPubMedPubMedCentralGoogle Scholar
  29. Gray, K. M., Watson, N. L., Carpenter, M. J., & Larowe, S. D. (2010). ‘N-acetylcysteine (NAC) in young marijuana users: An open-label pilot study’, The American Journal on Addictions, 19, 187–9.CrossRefPubMedPubMedCentralGoogle Scholar
  30. Haney M., Hart, C. L., Vosburg, S. K., Comer, S. D., Reed, S. C., & Foltin, R. W. (2008). ‘Effects of THC and lofexidine in a human laboratory model of marijuana withdrawal and relapse’, Psychopharmacology (Berlin, Germany), 197, 157–68.CrossRefGoogle Scholar
  31. Haney, M., Ward, A. S., Comer, S. D., Hart, C. L., Foltin, R. W., & Fischman, M. W. (2001). ‘Bupropion SR worsens mood during marijuana withdrawal in humans’, Psychopharmacology (Berlin, Germany), 155, 171–9.CrossRefGoogle Scholar
  32. Huestis, M. A., Gorelick, D. A., Heishman, S. J., Preston, K. L., Nelson, R. A., Moolchan, E. T., & Frank, R. A. (2001). ‘Blockade of effects of smoked marijuana by the CB1-selective cannabinoid receptor antagonist SR141716’, Archives of General Psychiatry, 58, 322–8.CrossRefPubMedGoogle Scholar
  33. Heyman, G. M. (2009). Addiction: A disorder of choice. (Boston, MA: Harvard University Press).Google Scholar
  34. Houben, K., Havermans, R. C., Nederkoorn, C., & Jansen, A. (2012). ‘Beer a no-go: Learning to stop responding to alcohol cues reduces alcohol intake via reduced affective associations rather than increased response inhibition’, Addiction, 107, 1280–7.CrossRefPubMedGoogle Scholar
  35. Houben, K., Nederkoorn, C., Wiers, R. W., & Jansen, A. (2011). ‘Resisting temptation: Decreasing alcohol-related affect and drinking behavior by training response inhibition’, Drug and Alcohol Dependence, 116, 132–6.CrossRefPubMedGoogle Scholar
  36. Houben, K., Wiers, R. W., & Jansen, A. (2011). ‘Getting a grip on drinking behavior: Training working memory to reduce alcohol abuse’, Psychological Science, 22, 968–75.CrossRefPubMedGoogle Scholar
  37. Jansen, J. M., Daams, J. G., Koeter, M. W., Veltman, D. J., van den Brink, W., & Goudriaan, A. E. (2013). ‘Effects of non-invasive neurostimulation on craving: A meta-analysis’, Neuroscience and Biobehavioral Reviews, 37, 2472–80.CrossRefPubMedGoogle Scholar
  38. Kane, M. J., & Engle, R. W. (2002). ‘The role of prefrontal cortex in working-memory capacity, executive attention, and general fluid intelligence: An individual-differences perspective’, Psychonomic Bulletin & Review, 9, 637–71.CrossRefGoogle Scholar
  39. Keren, G., & Schul, Y. (2009). ‘Two is not always better than one: A critical evaluation of two-system theories’, Perspectives on Psychological Science, 4, 533–50.CrossRefPubMedGoogle Scholar
  40. Leshner, A. I. (1997). ‘Addiction is a brain disease, and it matters’, Science, 278, 45–7.CrossRefPubMedGoogle Scholar
  41. Levin, F. R., & Kleber, H. D. (2008). ‘Use of dronabinol for cannabis dependence: Two case reports and review’, The American Journal of Addictions, 17, 161–4.CrossRefGoogle Scholar
  42. Lundahl, L. H., & Johanson, C. E. (2011). ‘Cue-induced craving for marijuana in cannabis-dependent adults’, Experimental and Clinical Psychopharmacology, 19, 224–30.CrossRefPubMedGoogle Scholar
  43. McRae-Clark, A. L., Carter, R. E., Killeen, T. K., Carpenter, M. J., Wahlquist, A. E., Simpson, S. A., & Brady, K. T. (2009). A placebo-controlled trial of buspirone for the treatment of marijuana dependence’, Drug and Alcohol Dependence, 105, 132–8.CrossRefPubMedPubMedCentralGoogle Scholar
  44. Morrison, A. B., & Chein, J. M. (2011). ‘Does working memory training work? The promise and challenges of enhancing cognition by training working memory’, Psychonomic Bulletin & Review, 18, 46–60.CrossRefGoogle Scholar
  45. Murray, R. M., Morrison, P. D., Henquet, C., & Di Forti, M. (2007). ‘Cannabis, the mind and society: The hash realities’, Nature Reviews Neuroscience, 8, 885–95.CrossRefPubMedGoogle Scholar
  46. Nutt, D. J., King, L. A., & Phillips, L. D. (2010). ‘Drug harms in the UK: A multicriteria decision analysis’, Lancet, 376, 1558–65.CrossRefPubMedGoogle Scholar
  47. Ochsner, K. N., Silvers, J. A., & Buhle, J. T. (2012). ‘Functional imaging studies of emotion regulation: A synthetic review and evolving model of the cognitive control of emotion’, Annals of the New York Academy of Sciences, 1251, E1–24.CrossRefGoogle Scholar
  48. Orford, J. (2001). ‘Addiction as excessive appetite’, Addiction, 96, 15–31.CrossRefPubMedGoogle Scholar
  49. Rahioui, H., Benyamina, A., & Reynaud, M. (2005). ‘Treatment of cannabis dependence’, La Revue du Praticien, 55, 64–70; discussion 71–2.PubMedGoogle Scholar
  50. Rinck, M., & Becker, E. S. (2007). ‘Approach and avoidance in fear of spiders’, Journal of Behavior Therapy and Experimental Psychiatry, 38, 105–20.CrossRefPubMedGoogle Scholar
  51. Robinson, T. E., & Berridge, K. C. (2003). ‘Addiction’, Annual Review of Psychology, 54, 25–53.CrossRefPubMedGoogle Scholar
  52. Schoenmakers, T., De Bruin, M., Lux, I. R, Goertz, A. G., van Kerkhof, D. H., & Wiers, R. W. (2010). ‘Clinical effectiveness of attentional bias modification training in abstinent alcoholic patients’, Drug and Alcohol Dependence, 109, 30–6.CrossRefPubMedGoogle Scholar
  53. Shafa, R. (2009). ‘COMT-inhibitors may be a promising tool in treatment of marijuana addiction trials’, The American Journal on Addictions, 18, 322.Google Scholar
  54. Sugarman, D. E., Poling, J., & Sofuoglu, M. (2011). ‘The safety of modafinil in combination with oral 9-tetrahydrocannabinol in humans’, Pharmacololgy, Biochemistry, and Behavior, 98, 94–100.CrossRefGoogle Scholar
  55. Tirado, C. F., Goldman, M., Lynch, K., Kampman, K. M., & O’Brien, C. P. (2008). ‘Atomoxetine for treatment of marijuana dependence: A report on the efficacy and high incidence of gastrointestinal adverse events in a pilot study’, Drug and Alcohol Dependence, 94, 254–7.CrossRefPubMedGoogle Scholar
  56. United Nations Office on Drugs and Crime. (2009). World Drug Report. Retrieved from http://www.unodc.org/documents/wdr/WDR_2009/WDR2009_eng_web.pdfGoogle Scholar
  57. van der Pol, P., Liebregts, N., de Graaf, R., Ten Have, M., Korf, D. J., van den Brink, W., & van Laar, M. (2013). ‘Mental health differences between frequent cannabis users with and without dependence and the general population’, Addiction, 108, 1459–69.CrossRefPubMedGoogle Scholar
  58. Vandrey R., & Haney M. (2009). ‘Pharmacotherapy for cannabis dependence: How close are we?’ CNS Drugs, 23, 543–53.CrossRefPubMedPubMedCentralGoogle Scholar
  59. Vandrey, R., Stitzer, M. L., Mintzer, M. Z., Huestis, M. A., Murray, J. A., & Lee, D. (2013). ‘The dose effects of short-term dronabinol (oral THC) maintenance in daily cannabis users’, Drug and Alcohol Dependence, 128, 64–70.CrossRefPubMedPubMedCentralGoogle Scholar
  60. Wachtel, S. R., & de Wit, H. (2000). ‘Naltrexone does not block the subjective effects of oral Delta(9)-tetrahydrocannabinol in humans’, Drug and Alcohol Dependence, 59, 251–60.CrossRefPubMedGoogle Scholar
  61. Weinstein, A. M., & Gorelick, D. A. (2011). ‘Pharmacological treatment of cannabis dependence’, Current Pharmaceutical Design, 17, 1351–8.CrossRefPubMedPubMedCentralGoogle Scholar
  62. Wiers, R. W., Bartholow, B. D., van den Wildenberg, E., Thush, C., Engels, R. C., Sher, K. J., … Stacy, A. W. (2007). ‘Automatic and controlled processes and the development of addictive behaviors in adolescents: A review and a model’, Pharmacology, Biochemistry, and Behavior, 86, 263–83.CrossRefPubMedGoogle Scholar
  63. Wiers, R. W., Eberl, C., Rinck, M., Becker, E. S., & Lindenmeyer, J. (2011). ‘Retraining automatic action tendencies changes alcoholic patients’ approach bias for alcohol and improves treatment outcome’, Psychological Science, 22, 490–7.CrossRefPubMedGoogle Scholar
  64. Wiers, R. W., Gladwin, T. E., Hofmann, W., Salemink, E., & Ridderinkhof, K. R. (2013). ‘Cognitive bias modification and cognitive control training in addiction and related psychopathology: Mechanisms, clinical perspectives, and ways forward’, Clinical Psychological Science, 1, 192–212.CrossRefGoogle Scholar
  65. Zumdick, S., Schneider, U., Leweke, M., Julicher, A., Tossmann, P., & Bonnet, U. (2006). ‘A survey on trials focussing on the treatment of cannabis-dependence’, Fortschritte der Neurologie-Psychiatrie, 74, 211–25.CrossRefPubMedGoogle Scholar

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© Janna Cousijn and Francesca Filbey 2015

Authors and Affiliations

  • Janna Cousijn
  • Francesca Filbey

There are no affiliations available

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