Neuropsychopharmacology in Addiction Treatment

  • Lara A. Ray
  • Kelly E. Courtney
  • Daniel Roche
  • Karen Miotto
Chapter

Abstract

There is a great deal of interest in understanding addiction neurobiology and in translating findings from pre-clinical studies to clinical samples. Functional magnetic resonance imaging (fMRI) represents an important tool in translating pre-clinical insights to brain function in humans affected by addictive disorders. While there has been a focus on developing fMRI-based biomarkers for psychiatric disorders in general (Fu & Costafreda, 2013), the field of addictions has yet to identify reliable biomarkers, fMRI based or otherwise. Importantly, diagnostic and prognostic biomarkers are only as useful as their ability to add value to existing clinical and behavioral systems. Perhaps most promising is the notion that understanding addiction neurobiology at the level of the individual’s brain function will allow for the development of more efficacious treatments, including the prediction of relapse and the test of promising behavioral and pharmacological interventions. In particular, it has been argued that therapies for addiction must target brain structures that are altered by the disorder through neuropsychological and pharmacological interventions (Konova et al., 2013b). Further, studies suggest that functional neuroimaging provides an objective and quantifiable measure for evaluating changes associated with treatment beyond what can be gathered from self-report or behavior alone (Menossi et al., 2013).

Keywords

Default Mode Network Ventral Striatum Addiction Treatment Cocaine Dependence Methadone Maintenance Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Bach, P., Vollstädt-Klein, S., Frischknecht, U., Hoerst, M., Kiefer, F., Mann, K., … Hermann, D. (2012). ‘Diminished brain functional magnetic resonance imaging activation in patients on opiate maintenance despite normal spatial working memory task performance’, Clinical Neuropharmacology, 35, 153–60.CrossRefPubMedGoogle Scholar
  2. Beck, A., Wustenberg, T., Genauck, A., Wrase, J., Schlagenhauf, F., Smolka, M. N., … Heinz, A. (2012). ‘Effect of brain structure, brain function, and brain connectivity on relapse in alcohol-dependent patients’, Archives of General Psychiatry, 69, 842–52.CrossRefPubMedGoogle Scholar
  3. Boettiger, C. A., Kelley E. A., Mitchell, J. M., D’Esposito, M., & Fields, H. L. (2009). ‘Now or Later? An fMRI study of the effects of endogenous opioid blockade on a decision-making network’, Pharmacology Biochemistry and Behavior, 93(3), 291–9.CrossRefGoogle Scholar
  4. Brewer J. A., Worhunsky, P. D., Carroll, K. M., Rounsaville, B. J., & Potenza, M. N. (2008). ‘Pretreatment brain activation during Stroop task is associated with outcomes in cocaine-dependent patients’, Biological Psychiatry, 64, 998–1004.CrossRefPubMedPubMedCentralGoogle Scholar
  5. Chase, H. W., Eickhoff, S. B., Laird, A. R., & Hogarth, L. (2011). ‘The neural basis of drug stimulus processing and craving: An activation likelihood estimation meta-analysis’, Biological Psychiatry, 70, 785–93.CrossRefPubMedGoogle Scholar
  6. Clark, V. P., Beatty G. K., Anderson, R. E., Kodituwakku, P., Phillips, J. P., Lane, T. D., … Calhoun, V. D. (2014). ‘Reduced fMRI activity predicts relapse in patients recovering from stimulant dependence’, Human Brain Mapping, 35, 414–28.CrossRefPubMedPubMedCentralGoogle Scholar
  7. Claus, E. D., Feldstein Ewing, S. W., Filbey, F. M., Sabbineni, A., & Hutchison, K. E. (2011). ‘Identifying neurobiological phenotypes associated with alcohol use disorder severity’, Neuropsychopharmacology, 36, 2086–96.CrossRefPubMedPubMedCentralGoogle Scholar
  8. Cosgrove, K. P., Batis, J., Bois, F., Maciejewski, P. K., Esterlis, L, Kloczynski, T., … Staley J. K. (2009). ‘beta2-Nicotinic acetylcholine receptor availability during acute and prolonged abstinence from tobacco smoking’, Archives of General Psychiatry, 66, 666–76.CrossRefPubMedPubMedCentralGoogle Scholar
  9. Courtney, K. E., Ghahremani, D. G., London, E. D., & Ray L. A. (2014). ‘The association between cue-reactivity in the precuneus and level of dependence on nicotine and alcohol’, Drug and Alcohol Dependence, 141, 21–6.CrossRefPubMedPubMedCentralGoogle Scholar
  10. Culbertson, C. S., Bramen, J., Cohen, M. S., London, E. D., Olmstead, R. E., Gan, J. J., … Brody A. L. (2011). ‘Effect of bupropion treatment on brain activation induced by cigarette-related cues in smokers’, Archives of General Psychiatry, 68, 505–15.CrossRefPubMedPubMedCentralGoogle Scholar
  11. Engelmann, J. M., Versace, F., Robinson, J. D., Minnix, J. A., Lam, C. Y., Cui, Y., … Cinciripini, P. M. (2012). ‘Neural substrates of smoking cue reactivity: A metaanalysis of fMRI studies’, NeuroImage, 60, 252–62.CrossRefPubMedPubMedCentralGoogle Scholar
  12. Ersche, K. D., Bullmore, E. T, Craig, K.J., Shabbir, S. S., Abbott, S., Müller, U., … Robbins, T. W. (2010). ‘Influence of compulsivity of drug abuse on dopaminergic modulation of attentional bias in stimulant dependence’, Archives of General Psychiatry, 67, 632–44.CrossRefPubMedPubMedCentralGoogle Scholar
  13. Ersche, K. D., Roiser, J. P., Abbott, S., Craig, K. J., Müller, U., Suckling, J., … Bullmore, E. T. (2011). ‘Response perseveration in stimulant dependence is associated with striatal dysfunction and can be ameliorated by a D(2/3) receptor agonist’, Biological Psychiatry, 70, 754–62.CrossRefPubMedGoogle Scholar
  14. Feldstein Ewing, S. W., & Chung, T. (2013). ‘Neuroimaging mechanisms of change in psychotherapy for addictive behaviors: Emerging translational approaches that bridge biology and behavior’, Psychology of Addictive Behaviors, 27, 329–35.CrossRefGoogle Scholar
  15. Forman, S. D., Dougherty, G. G., Casey, B. J., Siegle, G. J., Braver, T. S., Barch, D. M., … Lorenson, E. (2004). ‘Opiate addicts lack error-dependent activation of rostral anterior cingulate’, Biological Psychiatry, 55, 531–37.CrossRefPubMedGoogle Scholar
  16. Fox, H. C., Seo, D., Tuit, K., Hansen, J., Kimmerling, A., Morgan, P. T., & Sinha, R. (2012). ‘Guanfacine effects on stress, drug craving and prefrontal activation in cocaine dependent individuals: Preliminary findings’, Journal of Psychopharmacology 26, 958–72.CrossRefPubMedPubMedCentralGoogle Scholar
  17. Franklin, T. R., Harper, D., Kampman, K., Kildea-McCrea, S., Jens, W., Lynch, K. G., … Childress, A. R. (2009). ‘The GABA B agonist baclofen reduces cigarette consumption in a preliminary double-blind placebo-controlled smoking reduction study’, Drug and Alcohol Dependence, 103, 30–6.CrossRefPubMedPubMedCentralGoogle Scholar
  18. Franklin, T. R., Shin, J., Jagannathan, K., Suh, J. J., Detre, J. A., O’Brien, C. P., & Childress, A. R. (2012). ‘Acute baclofen diminishes resting baseline blood flow to limbic structures: A perfusion fMRI study’, Drug and Alcohol Dependence, 125, 60–6.CrossRefPubMedPubMedCentralGoogle Scholar
  19. Franklin, T. R., Wang, Z., Sciortino, N., Harper, D., Li, Y., Hakun, J., … Childress, A. R. (2011). ‘Modulation of resting brain cerebral blood flow by the GABA B agonist, baclofen: A longitudinal perfusion fMRI study’, Drug and Alcohol Dependence, 117, 176–83.CrossRefPubMedPubMedCentralGoogle Scholar
  20. Franklin, T. R., Wang, Z., Suh, J. J., Hazan, R., Cruz, J., Li, Y., … Childress, A. R. (2011). ‘Effects of varenicline on smoking cue-triggered neural and craving responses’, Archives of General Psychiatry, 68, 516–26.CrossRefPubMedPubMedCentralGoogle Scholar
  21. Fu, C. H., & Costafreda, S. G. (2013). ‘Neuroimaging-based biomarkers in psychiatry: Clinical opportunities of a paradigm shift’, Canadian Journal of Psychiatry, 58(9), 499–508.PubMedGoogle Scholar
  22. Ghahremani, D. G., Tabibnia, G., Monterosso, J., Hellemann, G., Poldrack, R. A., & London, E. D. (2011). ‘Effect of modafinil on learning and task-related brain activity in methamphetamine-dependent and healthy individuals’, Neuropsychopharmacology, 36(5), 950–9.CrossRefPubMedPubMedCentralGoogle Scholar
  23. Gilman, J. M., Ramchandani, V. A., Davis, M. B., Bjork, J. M., & Hommer, D. W. (2008). ‘Why we like to drink: A functional magnetic resonance imaging study of the rewarding and anxiolytic effects of alcohol’, The Journal of Neuroscience, 28, 4583–91.CrossRefPubMedPubMedCentralGoogle Scholar
  24. Goldstein, R. Z., & Volkow, N. D. (2011). ‘Dysfunction of the prefrontal cortex in addiction: Neuroimaging findings and clinical implications’, Nature Reviews Neuroscience, 12, 652–69.CrossRefPubMedPubMedCentralGoogle Scholar
  25. Goldstein, R. Z., Woicik, P. A., Maloney T, Tomasi, D., Alia-Klein, N., Shan, J., … Volkow, N. D. (2010). ‘Oral methylphenidate normalizes cingulate activity in cocaine addiction during a salient cognitive task’, Proceedings of the National Academy of Sciences of the United States of America, 107, 16667–72.CrossRefPubMedPubMedCentralGoogle Scholar
  26. Gotti, C., Zoli, M., & Clementi, F. (2006). ‘Brain nicotinic acetylcholine receptors: Native subtypes and their relevance’, Trends in Pharmacological Sciences, 27, 482–91.CrossRefPubMedGoogle Scholar
  27. Goudriaan, A. E., Veltman, D. J., van den Brink, W., Dom, G., & Schmaal, L. (2013). ‘Neurophysiological effects of modafinil on cue-exposure in cocaine dependence: A randomized placebo-controlled cross-over study using pharmacological fMRI’, Addictive Behaviors, 38, 1509–17.CrossRefPubMedGoogle Scholar
  28. Gradin, V B., Baldacchino, A., Balfour, D., Matthews, K., Steele, J. D. (2014). ‘Abnormal brain activity during a reward and loss task in opiate-dependent patients receiving methadone maintenance therapy’, Neuropsychopharmacology, 39, 885–94.CrossRefPubMedPubMedCentralGoogle Scholar
  29. Grüsser, S. M., Wrase, J., Klein, S., Hermann, D., Smolka, M. N., Ruf, M., … Heinz, A. (2004). ‘Cue-induced activation of the striatum and medial prefrontal cortex is associated with subsequent relapse in abstinent alcoholics’, Psychopharmacology (Berlin, Germany), 175, 296–302.CrossRefGoogle Scholar
  30. Han, D. H., Kim, S. M., Choi, J. E., Min, K. J., & Renshaw, P. F. (2013). ‘Adjunctive aripiprazole therapy with escitalopram in patients with co-morbid major depressive disorder and alcohol dependence: Clinical and neuroimaging evidence’, Journal of Psychopharmacology, 27, 282–91.CrossRefPubMedPubMedCentralGoogle Scholar
  31. Hasin, D. S., O’Brien, C. P., Auriacombe, M., Borges, G., Bucholz, K., Budney A., … Grant, B. F. (2013). ‘DSM-5 criteria for substance use disorders: Recommendations and rationale. American Journal of Psychiatry, 170, 834–51.CrossRefPubMedPubMedCentralGoogle Scholar
  32. Hermann, D., Smolka, M. N., Wrase, J., Klein, S., Nikitopoulos, J., Georgi, A., … Heinz, A. (2006). ‘Blockade of cue-induced brain activation of abstinent alcoholics by a single administration of amisulpride as measured with fMRI’, Alcoholism: Clinical and Experimental Research, 30, 1349–54.CrossRefGoogle Scholar
  33. Hutchison, K. E. (2008). ‘Alcohol dependence: Neuroimaging and the development of translational phenotypes’, Alcoholism: Clinical and Experimental Research, 32, 1111–12.CrossRefGoogle Scholar
  34. Janes, A. C., Pizzagalli, D. A., Richardt, S., Frederick, B. deB., Chuzi, S., Pachas, G., … Kaufman, M. J. (2010). ‘Brain reactivity to smoking cues prior to smoking cessation predicts ability to maintain tobacco abstinence’, Biological Psychiatry, 67, 722–29.CrossRefPubMedPubMedCentralGoogle Scholar
  35. Jasinska, A. J., Chua, H. F., Ho, S. S., Polk, T. A., Rozek, L. S., & Strecher, V. J. (2012). ‘Amygdala response to smoking-cessation messages mediates the effects of serotonin transporter gene variation on quitting’, Neuroimage, 60, 766–73.CrossRefPubMedPubMedCentralGoogle Scholar
  36. Jasinska, A. J., Stein, E. A., Kaiser, J., Naumer, M. J., & Yalachkov, Y. (2014). ‘Factors modulating neural reactivity to drug cues in addiction: A survey of human neuroimaging studies’, Neuroscience & Biobehavioral Reviews, 38, 1–16.CrossRefGoogle Scholar
  37. Jasinska, A. J., Stein, E. A., Kaiser, J., Naumer, M. J., & Yalachkov, Y. (2014). ‘Factors modulating neural reactivity to drug cues in addiction: A survey of human neuroimaging studies’, Neuroscience & Biobehavioral Reviews, 38, 1–16.CrossRefGoogle Scholar
  38. Jiang, G. H., Qiu, Y. W., Zhang, X. L., Han, L. J., Lv, X. F., Li, L. M., … Tian, J. Z. (2011). ‘Amplitude low-frequency oscillation abnormalities in the heroin users: A resting state fMRI study’, Neuroimage, 57, 149–54.CrossRefPubMedGoogle Scholar
  39. Kalivas, P. W., & Volkow, N. D. (2005). ‘The neural basis of addiction: A pathology of motivation and choice’, American Journal of Psychiatry, 162, 1403–13.CrossRefPubMedGoogle Scholar
  40. Konova, A. B., Moeller, S. J., & Goldstein, R. Z. (2013). ‘Common and distinct neural targets of treatment: Changing brain function in substance addiction’, Neuroscience & Biobehavioral Reviews, 37, 2806–17.CrossRefGoogle Scholar
  41. Konova, A. B., Moeller, S. J., Tomasi, D., Volkow, N. D., & Goldstein, R. Z. (2013). ‘Effects of methylphenidate on resting-state functional connectivity of the mesocorticolimbic dopamine pathways in cocaine addiction’, JAMA Psychiatry, 70, 857–68.CrossRefPubMedPubMedCentralGoogle Scholar
  42. Kosten, T. R., Scanley B. E., Tucker, K. A., Oliveto, A., Prince, C., Sinha, R., … Wexler, B. E. (2006). ‘Cue-induced brain activity changes and relapse in cocaine-dependent patients’, Neuropsychopharmacology, 31, 644–50.CrossRefPubMedGoogle Scholar
  43. Langleben, D. D., Ruparel, K., Elman, I., Busch-Winokur, S., Pratiwadi, R., Loughead, J., … Childress, A. R. (2008). ‘Acute effect of methadone maintenance dose on brain fMRI response to heroin-related cues’, American Journal of Psychiatry, 165, 390–4.CrossRefPubMedGoogle Scholar
  44. Langosch, J. M., Spiegelhalder, K., Jahnke, K., Feige, B., Regen, W., Kiemen, A., … Olbrich, H. M. (2012). ‘The impact of acamprosate on cue reactivity in alcohol dependent individuals: A functional magnetic resonance imaging study’, Journal of Clinical Psychopharmacology, 32, 661–5.CrossRefPubMedGoogle Scholar
  45. Li, C. S., Morgan, P. T, Matuskey, D., Abdelghany, O., Luo, X., Chang, J. L., … Malison, R. T. (2010). ‘Biological markers of the effects of intravenous methylphenidate on improving inhibitory control in cocaine-dependent patients’, Proceedings of the National Academy of Sciences of the United States of America, 107, 14455–9.CrossRefPubMedPubMedCentralGoogle Scholar
  46. Litten, R. Z., Egli, M., Heilig, M., Cui, C., Fertig, J. B., Ryan, M. L., … Noronha, A. (2012). ‘Medications development to treat alcohol dependence: A vision for the next decade’, Addiction Biology, 17, 513–27.CrossRefPubMedPubMedCentralGoogle Scholar
  47. Loughead, J., Ray R., Wileyto, E. P., Ruparel, K., O’Donnell, G. P., Senecal, N., … Lerman, C. (2013). ‘Brain activity and emotional processing in smokers treated with varenicline’, Addiction Biology, 18, 732–8.CrossRefPubMedGoogle Scholar
  48. Loughead, J., Ray R., Wileyto, E. P., Ruparel, K., Sanborn, P., Siegel, S., … Lerman C. (2010). ‘Effects of the α4β2 partial agonist varenicline on brain activity and working memory in abstinent smokers’, Biological Psychiatry, 67, 715–21.CrossRefPubMedGoogle Scholar
  49. Lukas, S. E., Lowen, S. B., Lindsey K. P., Conn, N., Tartarini, W., Rodolico, J., … Penetar, D. M. (2013). ‘Extended-release naltrexone (XR-NTX) attenuates brain responses to alcohol cues in alcohol-dependent volunteers: A bold fMRI study’, Neuroimage 78, 176–85.CrossRefPubMedGoogle Scholar
  50. Ma, N., Liu, Y., Li, N., Wang, C. X., Zhang, H., Jiang, X. F., … Zhang, D. R. (2010). ‘Addiction related alteration in resting-state brain connectivity’, Neuroimage, 49, 738–44.CrossRefPubMedPubMedCentralGoogle Scholar
  51. Mann, K., Kiefer, F., Smolka, M., Gann, H., Wellek, S., Heinz, A., & the PREDICT Study Research Team. (2009). ‘Searching for responders to acamprosate and naltrexone in alcoholism treatment: Rationale and design of the PREDICT study’, Alcoholism: Clinical and Experimental Research, 33, 674–83.CrossRefGoogle Scholar
  52. Marhe, R., Luijten, M., van de Wetering, B. J., Smits, M., & Franken, I. H. (2013). ‘Individual differences in anterior cingulate activation associated with attentional bias predict cocaine use after treatment’, Neuropsychopharmacology, 38, 1085–93.CrossRefPubMedPubMedCentralGoogle Scholar
  53. Marvel, C. L., Faulkner, M. L., Strain, E. C., Mintzer, M. Z., & Desmond, J. E. (2012). ‘An fMRI investigation of cerebellar function during verbal working memory in methadone maintenance patients’, Cerebellum, 11, 300–10.CrossRefPubMedPubMedCentralGoogle Scholar
  54. Matuskey, D., Luo, X., Zhang, S., Morgan, P. T, Abdelghany, O., Malison, R. T, & Li, C. S. (2013). ‘Methylphenidate remediates error-preceding activation of the default mode brain regions in cocaine-addicted individuals’, Psychiatry Research, 214, 116–21.CrossRefPubMedGoogle Scholar
  55. McClernon, F. J., Hiott, F. B., Liu, J., Salley A. N., Behm, F. M., & Rose, J. E. (2007). ‘Selectively reduced responses to smoking cues in amygdala following extinction-based smoking cessation: Results of a preliminary functional magnetic resonance imaging study’, Addiction Biology, 12, 503–12.CrossRefPubMedGoogle Scholar
  56. McHugh, M. J., Deniers, C. H., Salmeron, B. J., Devous Sr., M. D., Stein, E. A., & Adinoff, B. (2014). ‘Cortico-amygdala coupling as a marker of early relapse risk in cocaine-addicted individuals’, Front Psychiatry, 5.Google Scholar
  57. Mei, W., Zhang, J. X., & Xiao, Z. (2010). ‘Acute effects of sublingual buprenorphine on brain responses to heroin-related cues in early-abstinent heroin addicts: An uncontrolled trial’, Neuroscience, 170, 808–15.CrossRefPubMedGoogle Scholar
  58. Menossi, H. S., Goudriaan, A. E., de Azevedo-Marques Périco, C., Nicastri, S., de Andrade, A. G., D’Elia, G., … Castaldelli-Maia, J. M. (2013). ‘Neural bases of pharmacological treatment of nicotine dependence — insights from functional brain imaging: A systematic review’, CNS Drugs, 27, 921–41.CrossRefPubMedGoogle Scholar
  59. Mihalak, K. B., Carroll, F. I., & Luetje, C. W. (2006). ‘Varenicline is a partial agonist at α4β2 and a full agonist at α7 neuronal nicotinic receptors’, Molecular Pharmacology, 70, 801–5.CrossRefPubMedGoogle Scholar
  60. Mitchell, J. M., Tavares, V. C., Fields, H. L., D’Esposito, M., & Boettiger, C. A. (2007). ‘Endogenous opioid blockade and impulsive responding in alcoholics and healthy controls’, Neuropsychopharmacology 32, 439–49.CrossRefPubMedGoogle Scholar
  61. Mitchell, M. R., Balodis, I. M., DeVito, E. E., Lacadie, C. M., Yeston, J., Scheinost, D., … Potenza, M. N. (2013). ‘A preliminary investigation of Stroop-related intrinsic connectivity in cocaine dependence: Associations with treatment outcomes’, The American Journal of Drug and Alcohol Abuse, 39, 392–402.CrossRefPubMedGoogle Scholar
  62. Moeller, R G., Steinberg, J. L., Schmitz, J. M., Ma, L., Liu, S., Kjome, K. L., … Narayana, P. A. (2010). Working memory fMRI activation in cocaine-dependent subjects: Association with treatment response’, Psychiatry Research, 181, 174–82.CrossRefPubMedPubMedCentralGoogle Scholar
  63. Monti, P. M., Tidey J., Czachowski, C. L., Grant, K. A., Rohsenow, D. J., Sayette, M., … Pierre, P. (2004). ‘Building bridges: The transdisciplinary study of craving from the animal laboratory to the lamppost’, Alcoholism: Clinical and Experimental Research, 28, 279–87.CrossRefGoogle Scholar
  64. Myrick, H., Anton, R. R, Li, X., Henderson, S., Drobes, D., Voronin, K., & George, M. S. (2004). ‘Differential brain activity in alcoholics and social drinkers to alcohol cues: Relationship to craving’, Neuropsychopharmacology, 29, 393–402.CrossRefPubMedGoogle Scholar
  65. Myrick, H., Anton, R. R, Li, X., Henderson, S., Randall, P. K., & Voronin, K. (2008). ‘Effect of naltrexone and ondansetron on alcohol cue-induced activation of the ventral striatum in alcohol-dependent people’, Archives of General Psychiatry, 65, 466–75.CrossRefPubMedPubMedCentralGoogle Scholar
  66. Myrick, H., Li, X., Randall, P. K., Henderson, S., Voronin, K., & Anton, R. R (2010). ‘The effect of aripiprazole on cue-induced brain activation and drinking parameters in alcoholics’, Journal of Clinical Psychopharmacology, 30, 365–72.CrossRefPubMedPubMedCentralGoogle Scholar
  67. Parvaz, M. A., Alia-Klein, N., Woicik, P. A., Volkow, N. D., & Goldstein, R. Z. (2011). ‘Neuroimaging for drug addiction and related behaviors’, Reviews in the Neurosciences, 22, 609–24.CrossRefPubMedPubMedCentralGoogle Scholar
  68. Paulus, M. P., Tapert, S. R, & Schuckit, M. A. (2005). ‘Neural activation patterns of methamphetamine-dependent subjects during decision making predict relapse’, Archives of General Psychiatry, 62, 761–8.CrossRefPubMedGoogle Scholar
  69. Prisciandaro, J. J., Myrick, H., Henderson, S., McRae-Clark, A. L., Santa Ana, E. J., Saladin, M. E., … Brady, K. T. (2013). ‘Impact of DCS-facilitated cue exposure therapy on brain activation to cocaine cues in cocaine dependence’, Drug and Alcohol Dependence, 132, 195–201.CrossRefPubMedPubMedCentralGoogle Scholar
  70. Qiu, Y. W., Han, L. J., Lv, X. F., Jiang, G. H., Tian, J. Z., Zhuo, F. Z., … Zhang, X. L. (2011). ‘Regional homogeneity changes in heroin-dependent individuals: Resting-state functional MR imaging study’, Radiology, 261, 551–9.CrossRefPubMedGoogle Scholar
  71. Ray L. A., Barr, C. S., Blendy J. A., Oslin, D., Goldman, D., & Anton, R. F. (2012). ‘The role of the Asn40Asp polymorphism of the mu opioid receptor gene (OPRM1) on alcoholism etiology and treatment: A critical review’, Alcoholism: Clinical and Experimental Research, 36, 385–94.CrossRefGoogle Scholar
  72. Ray, L. A., Courtney, K. E., Ghahremani, D. G., Miotto, K., Brody A., & London, E. D. (2014). ‘Varenicline, naltrexone, and their combination for heavy-drinking smokers: Preliminary neuroimaging findings’, The American Journal of Drug and Alcohol Abuse, 20, 1–10.Google Scholar
  73. Robinson, T. E., & Berridge, K. C. (1993). ‘The neural basis of drug craving: An incentive-sensitization theory of addiction’, Brain Research Reviews, 18, 247–91.CrossRefPubMedGoogle Scholar
  74. Rollema, H., Chambers, L. K., Coe, J. W., Glowa, J., Hurst, R. S., Lebel, L. A., … Williams, K. E. (2007). ‘Pharmacological profile of the α4α2 nicotinic acetylcholine receptor partial agonist varenicline, an effective smoking cessation aid’, Neuropharmacology, 52, 985–94.CrossRefPubMedGoogle Scholar
  75. Rollema, H., Hajos, M., Seymour, P. A., Kozak, R., Majchrzak, M. J., Guanowsky V., … Williams K. E. (2009). ‘Preclinical pharmacology of the α4β2 nAChR partial agonist varenicline related to effects on reward, mood and cognition’, Biochemical Pharmacology, 78, 813–24.CrossRefPubMedGoogle Scholar
  76. Sarter, M., Parikh, V., & Howe, W. M. (2009). ‘nAChR agonist-induced cognition enhancement: Integration of cognitive and neuronal mechanisms’, Biochemical Pharmacology, 78, 658–67.CrossRefPubMedPubMedCentralGoogle Scholar
  77. Schacht, J. P., Anton, R. F., & Myrick, H. (2013). ‘Functional neuroimaging studies of alcohol cue reactivity: A quantitative meta-analysis and systematic review’, Addiction Biology, 18, 121–33.CrossRefPubMedPubMedCentralGoogle Scholar
  78. Schacht, J. P., Anton, R. F., Randall, P. K., Li, X., Henderson, S., & Myrick, H. (2013). ‘Effects of a GABA-ergic medication combination and initial alcohol withdrawal severity on cue-elicited brain activation among treatment-seeking alcoholics’, Psychopharmacology (Berlin, Germany), 227, 627–37CrossRefGoogle Scholar
  79. Schacht, J. P., Anton, R. F., Voronin, K. E., Randall, P. K., Li, X., Henderson, S., & Myrick, H. (2012). ‘Interacting effects of naltrexone and OPRM1 and DAT1 variation on the neural response to alcohol cues’, Neuropsychopharmacology, 38, 414–22.CrossRefPubMedPubMedCentralGoogle Scholar
  80. Stewart, J. L., Connolly, C. G., May, A. C., Tapert, S. F., Wittmann, M., & Paulus, M. P. (2014). ‘Striatum and insula dysfunction during reinforcement learning differentiates abstinent and relapsed methamphetamine-dependent individuals’, Addiction, 109, 460–71.CrossRefPubMedPubMedCentralGoogle Scholar
  81. Sutherland, M. T, Carroll, A. J., Salmeron, B. J., Ross, T. J., Hong, L. E., & Stein, E. A. (2013). ‘Down-regulation of amygdala and insula functional circuits by varenicline and nicotine in abstinent cigarette smokers’, Biological Psychiatry, 74, 538–46.CrossRefPubMedPubMedCentralGoogle Scholar
  82. Versace, F., Engelmann, J. M., Robinson, J. D., Jackson, E. R, Green, C. E., Lam, C. Y., … Cinciripini, P. M. (2014). ‘Prequit fMRI responses to pleasant and cigarette cues predict smoking cessation outcome’, Nicotine & Tobacco Research, 16, 697–708.CrossRefGoogle Scholar
  83. Volkow, N. D., Wang, G. J., Fowler, J. S., & Tomasi, D. (2012). ‘Addiction circuitry in the human brain’, Annual Review of Pharmacology and Toxicology, 52, 321–36.CrossRefPubMedPubMedCentralGoogle Scholar
  84. Vollstädt-Klein, S., Loeber, S., Kirsch, M., Bach, P., Richter, A., Buhler, M., … Kiefer, F. (2011). ‘Effects of cue-exposure treatment on neural cue reactivity in alcohol dependence: A randomized trial’, Biological Psychiatry, 69, 1060–6.CrossRefPubMedGoogle Scholar
  85. Walter, M., Denier, N., Gerber, H., Schmid, O., Lanz, C., Brenneisen, R., … Borgwardt, S. (2014). ‘Orbitofrontal response to drug-related stimuli after heroin administration’, Addiction Biology.Google Scholar
  86. Wang, W., Li, Q., Wang, Y, Tian, J., Yang, W., Li, W., … Liu, J. (2011). ‘Brain fMRI and craving response to heroin-related cues in patients on methadone maintenance treatment’, The American Journal of Drug and Alcohol Abuse, 37, 123–30.CrossRefPubMedGoogle Scholar
  87. Wilson, S.J., Sayette, M. A., & Fiez, J. A. (2004). ‘Prefrontal responses to drug cues: A neurocognitive analysis’. Nature Neuroscience, 7, 211–14.CrossRefPubMedPubMedCentralGoogle Scholar
  88. Worhunsky P. D., Stevens, M. C., Carroll, K. M., Rounsaville, B. J., Calhoun, V. D., Pearlson, G. D., & Potenza, M. N. (2013). ‘Functional brain networks associated with cognitive control, cocaine dependence, and treatment outcome’, Psychology of Addictive Behaviors, 27, 477–88.CrossRefPubMedPubMedCentralGoogle Scholar
  89. Xu, K., Seo, D., Hodgkinson, C., Hu, Y, Goldman, D., & Sinha, R. (2013). ‘A variant on the kappa opioid receptor gene (OPRK1) is associated with stress response and related drug craving, limbic brain activation and cocaine relapse risk’, Translational Psychiatry 3, e292.CrossRefGoogle Scholar
  90. Young, K. A., Franklin, T. R., Roberts, D. C., Jagannathan, K., Suh, J. J., Wetherill, R. R., … Childress, A. R. (2014). ‘Nipping cue reactivity in the bud: Baclofen prevents limbic activation elicited by subliminal drug cues’, The Journal of Neuroscience, 34, 5038–43.CrossRefPubMedPubMedCentralGoogle Scholar
  91. Yücel, M., Lubman, D. I., Harrison, B. J., Fornito, A., Allen, N. B., Wellard, R. M., … Pantelis, C. (2007). ‘A combined spectroscopic and functional MRI investigation of the dorsal anterior cingulate region in opiate addiction’, Molecular Psychiatry, 12, 691–702.CrossRefGoogle Scholar

Copyright information

© Lara A. Ray, Kelly E. Courtney, Daniel Roche, and Karen Miotto 2015

Authors and Affiliations

  • Lara A. Ray
  • Kelly E. Courtney
  • Daniel Roche
  • Karen Miotto

There are no affiliations available

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