Controlling Biochemical Weapons pp 91-115 | Cite as
Behaviour Under Control: the Malign Misuse of Neuroscience
Abstract
Only in the last few centuries has the link between the brain and behaviour become clear, and only at the end of the nineteenth century was it demonstrated that the nervous system was made up of billions of separate nerve cells or neurons. We now know that during evolution complex networks of such neurons have developed in order to effect certain behaviours. Whilst the neurons of the central, peripheral and autonomic nervous systems vary enormously in form and function, they can be classed into three broad groups: sensory neurons which convey information into the central nervous system; effector neurons which carry information out of the central nervous system to muscles and other effector organs; and interneurons within the central nervous system which link the sensory and effector neurons and also have links with one another.
Keywords
Locus Coeruleus Excessive Daytime Sleepiness Memory Consolidation Nerve Agent Paradoxical SleepPreview
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Notes and References
- 1.SIPRI, The Problem of Chemical and Biological Warfare, Volume II of CB Weapons Today (Stockholm: Almqvist and Wiksell, 1973), pp.288–308 on novel chemical agents.Google Scholar
- 2.M. R. Dando, ‘Scientific and technological change and the future of the CWC: The problem of non-lethal weapons’, Disarmament Forum, 4, 2002, 33–44.Google Scholar
- 3.M. R. Dando, The Danger to the Chemical Weapons Convention from Incapacitating Chemicals, CWC Review Conference Paper No. 4, Department of Peace Studies, University of Bradford, 2003, available at: http://www.brad.ac.uk/acad/scwc.
- 4.H. Kitano, ‘Systems biology: a brief overview’, Introduction to a special section on systems biology: the Genome, Ligome and Beyond, Science, 295, 2002, 1662–4.CrossRefGoogle Scholar
- 5.E. J. Davidov, et al., ‘Advancing drug discovery through systems biology’, Drug Discovery Today, 8 (4), 2003, 175–83.CrossRefGoogle Scholar
- 6.C. M. Henry, ‘Systems biology: Integrative approach to drug discovery’, Chemical and Engineering News, 19 May 2003, 45–55.Google Scholar
- 7.L. Hood, ‘Leroy Hood expounds the principles, practice and future of systems biology’, Drug Discovery Today, 8 (10), 2003, 436–8.CrossRefGoogle Scholar
- 8.M. R. Dando, A New Form of Warfare: the Rise of Non-Lethal Weapons (London: Brassey’s, 1996), especially pp.136–68 (chapter 8, ‘An Assault on the Brain’).Google Scholar
- 9.J. M. Lakoski, et al., The Advantages and Limitations of Calmatives for Use as a Non-Lethal Technique, Applied Research Laboratory, College of Medicine, Pennsylvania State University, 2000.Google Scholar
- 10.A. Longstaff, Instant Notes: Neuroscience, 2nd edition (New York: Taylor and Francis, 2005).Google Scholar
- 11.Editorial, ‘New vistas for an old neurotransmitter’, Biological Psychiatry, 46 (9), 1999, 1121–3. (Introduction to a special issue covering pages 1121–320.)Google Scholar
- 12.G. Aston-Jones, et al., ‘Role of locus coeruleus in attention and behavioural flexibility’, Biological Psychiatry, 46 (9), 1999, 1309–20.CrossRefGoogle Scholar
- 13.B. Fernandez-Pastor, and J. J. Meana, ‘In vivo tonic modulation of the noradrenaline release in the rat cortex by locus coeruleus somatodendritic alpha2 adrenoceptors’, European Journal of Pharmacology, 442, 2002, 225–9.CrossRefGoogle Scholar
- 14.Edgewood RDEC, Scientific Conference in Chemical and Biological Defense Research: Abstract Digest, US Army Chemical and Biological Defense Command, Aberdeen Proving Ground, Maryland, 1989–94.Google Scholar
- 15.See Dando, A New Form of Warfare, note 8.Google Scholar
- 16.J. R. Docherty, ‘Subtypes of functional α1- and α2-adrenoceptors’, European Journal of Pharmacology, 361 (1), 1998, 1–15.CrossRefGoogle Scholar
- 17.M. M. Biicheler et al., ‘Two α2-adrenergic receptor subtypes, α2A and α2C, inhibit transmitter release in the brain of gene-targeted mice’, Neuroscience, 109 (4), 2002, 819–26.CrossRefGoogle Scholar
- 18.K. M. Small et al. ‘Pharmacology and physiology of human adrenergic receptor polymorphisms’, Annu. Rev. Pharmacol. Toxicol, 43, 2003, 381–411.CrossRefGoogle Scholar
- 19.See Dando, The Danger to the Chemical Weapons Convention, note 3.Google Scholar
- 20.SIPRI, The Problem of Chemical and Biological Warfare, note 1.Google Scholar
- 21.A. Frances and M. B. First, Your Mental Health: a Layman’s Guide to the Psychiatrists’ Bible (New York: Scribner, 1998), especially pp.109–16 (chapter 5, ‘Exposure to Traumatic Events’).Google Scholar
- 22.Longstaff, Instant Notes: Neuroscience, note 10.Google Scholar
- 23.J. LeDoux, ‘The power of emotions’, in R. Conlon (ed.), States of Mind: New Discoveries About How Our Brains Make Us Who We Are (New York: John Wiley and Sons 1999), pp.123–50.Google Scholar
- 24.J. L. McGough et al., ‘Amygdala modulation of memory consolidation: Interaction with other brain systems’, Neurobiology of Learning and Memory, 78, 2002, 539–52.CrossRefGoogle Scholar
- 25.B. Ferry and J. L. McGough, ‘Role of amygdala norepinephrine in mediating stress hormone regulation of memory storage’ Acta Pharmacol. Sin., 21 (6), 2000, 481–93.Google Scholar
- 26.J. L. McGough and B. Roozendaal, ‘Role of adrenal stress hormones in forming lasting memories in the brain’, Current Opinion in Neurobiology, 12, 2002, 205–10.CrossRefGoogle Scholar
- 27.B. Ferry et al., ‘Basolateral amygdala noradrenergic influences on memory storage are mediated by an interaction between β- and α1-adrenoceptors’, Journal of Neuroscience, 19 (2), 1999, 5119–123.Google Scholar
- B. Roozendaal, ‘Glucocortcoids and the regulation of memory consolidation’, Psychoneuroendocrinology, 25, 2000, 213–18.CrossRefGoogle Scholar
- 28.E. Vermetten and J. D. Bremner, ‘Circuits and systems in stress: I Preclinical Studies’, Depression and Anxiety, 15, 2002, 126–47.CrossRefGoogle Scholar
- 29.R. Grossman et al., ‘Neuroimaging studied on post-traumatic stress disorder’, Psychiatr. Clin. N. America, 25, 2002, 317–40.CrossRefGoogle Scholar
- 30.S. M. Southwick et al., ‘Role of norepinephrine in the pathophysiology and treatment of post-tramumatic stress disorder’, Biological Psychiatry, 46 (9), 1999, 1192–204.CrossRefGoogle Scholar
- 31.E. Baard, ‘The guilt-free soldier: New science raises the spectre of a world without regret’, The Village Voice, 22–8 January 2003.Google Scholar
- 32.F. C. Conahan, Human Experimentation: an Overview on Cold War Era Programs, Testimony before the Legislative and National Security Subcommittee, Committee on Government Operations, House of Representatives, September 28th. GAO/T-NSIAD-94-266 (Washington, DC: General Accounting Office 1994).Google Scholar
- 33.SIPRI, The Problem of Chemical and Biological Warfare, pp.302–03.Google Scholar
- 34.US Army Intelligence Agency, Letter Report: Incapacitating Agents, European Communist Countries, AST-1620R-100-90, US Army Foreign Science and Technology Center, 16 July 1990.Google Scholar
- 35.J. S. Ketchum and F. R. Sidell, ‘Incapacitating Agents’, in F. R. Sidell, E. T. Takafuji and D. R. Franz (eds), Medical Aspects of Chemical and Biological Warfare (Washington, DC: Office of the Surgeon General, 1997), pp.287–306.Google Scholar
- 36.See M. R. Dando, The Danger of the Chemical Weapons Convention from Incapacitating Chemicals.Google Scholar
- 37.M. R. Dando, A New Form of Warfare: the Rise of Non-Lethal Weapons (London: Brassey’s, 1996), pp.136–68.Google Scholar
- 38.E. Kagan, ‘Bioregulators as instruments of terror’, Clinics in Laboratory Medicine, 21 (3), 2001, 607–18.Google Scholar
- 39.B. Knickerbocker, ‘Military looks to drugs for battle readiness: As combat flights get longer, pilot use of amphetamines grows, as do side effects’, The Christian Science Monitor, 9 August 2002.Google Scholar
- 40.D-J. Dyk and S. W. Lockley, ‘Functional genomics of sleep and circadian rhythm’, J. Appl. Physiol., 92, 2002, 852–62.CrossRefGoogle Scholar
- G. K. Wang and A. Sehgal, ‘Signalling components that drive circadian rhythms’, Current Opinion in Neurobiology, 12, 2002, 331–8.CrossRefGoogle Scholar
- R. N. Van Gelder et al., ‘Circadian rhythms: in the loop at last’, Science, 300, 2003, 152–3.Google Scholar
- 41.M. R. Dando, The New Biological Weapons: Threat, Proliferation and Control (Boulder, CO: Lynne Rienner, 2001), pp.103–16.Google Scholar
- 42.‘Scope/Information’, Nature Reviews: Neuroscience, available at: http://www.nature.com/nrn/info/scope.html.
- 43.T. Ideker, T. Galitski and L. Hood, ‘A new approach to decoding life: Systems biology’, Ann. Rev. Genomics Hum. Genet., 2, 2001, 343–72.CrossRefGoogle Scholar
- 44.M. M. Francis, J. E. Mellem and A. Villu Mericq, ‘Bridging the gap between genes and behaviour: recent advances in the electophysiological analysis of neural function’, Caenorhabditis elegans. Trends in Neuroscience, 26 (2), 2003, 90–9.CrossRefGoogle Scholar
- 45.United Kingdom, Background Paper on New Scientific and Technological Developments. Fifth Review Conference of the States Parties to the Convention on the Prohibition of the Development, Production and Stockpiling of Bacteriological (Biological) and Toxin Weapons and on their Destruction. BWC/CONF.V/4/Add.1 (Geneva, 26 October 2001).Google Scholar
- 46.M. R. Dando, A New Form of Warfare: the Rise of Non-Lethal Weapons (London: Brassey’s, 1996), especially chapter 6, ‘The Human Nervous System’.Google Scholar
- 47.R. R. Lliñas, I of the Vortex: From Neurons to Self (Cambridge, MA: MIT Press, 2002).Google Scholar
- 48.M. W. Dubin, How the Brain Works (Oxford: Blackwell, 2002).Google Scholar
- 49.R R. Sidell, ‘Nerve Agents’, in R R. Sidell, E. T. Takafuji and D. R. Franz (eds), Medical Aspects of Chemical and Biological Warfare (Washington, DC: Office of the Surgeon General, US Army, 1997), pp.129–80.Google Scholar
- 50.J. S. Ketchum, and R R. Sidell, ‘Incapacitating Agents’, note 32.Google Scholar
- 51.E. J. Nestler et al., Molecular Neuropharmacology: a Foundation for Clinical Neuroscience (New York: McGraw-Hill Medical, 2001).Google Scholar
- 52.C. C. Felder et al., ‘Therapeutic opportunities for muscarinic receptors in the central nervous system’, J. Medical Chemistry, 43 (23), 2000, 4333–53.CrossRefGoogle Scholar
- 53.N. J. M. Birdsall, ‘Muscarinic acetylcholine receptors’, The IUPHAR Receptor Compendium (London: IUPHAR Media, 1998), pp.37–45.Google Scholar
- 54.R P. Bymaster et al., ‘Use of M1-M5 muscarinic receptor knockout mice as novel tools to delineate the physiological roles of the muscarinic choliergic system’, Neurochem. Res., 28 (3–4), 2003, 437–42.CrossRefGoogle Scholar
- 55.W. Zhang et al., ‘Characterization of central inhibitory muscarinic autoreceptors by the use of muscarinic acetylcholine receptor knock-out mice’, J. Neuroscience, 22 (5), 2002, 1709–17.Google Scholar
- 56.J. E. Lachowicz et al., ‘Discovery of SCH211803, a high affinity, selective M2 receptor antagonist and a novel approach to treatment of Alzheimer’s Disease’, Soc. Neurosci. Abstr., 27, 2001, 679.Google Scholar
- 57.Y. Wang, et al., ‘Improving the oral efficacy of CNS drug candidates: Discovery of highly orally efficacious piperidinyl piperidine M2 muscarinic receptor antagonists’, J. Medical Chemistry, 45 (25), 2002, 5415–18.CrossRefGoogle Scholar
- 58.A. Lonsgstaff, Instant Notes: Neuroscience. 2nd edition (New York: Taylor and Francis, 2000), especially section M4, ‘Brain Biological Clocks’.Google Scholar
- 59.H. Okamura, ‘Integration of mammalian circadian clock signals: from molecule to behaviour’, Journal of Endocrinology, 177, 2003, 3–6.CrossRefGoogle Scholar
- 60.H. D. Piggins and D.J. Cutler, ‘The roles of vasocactive intestinal polypeptide in the mammalian circadian clock’, Journal of Endocrinology, 177, 2003, 7–15.CrossRefGoogle Scholar
- 61.A. Longstaff, ‘Sleep’, Section 04, in note 58.Google Scholar
- 62.W. McDowell Anderson, ‘Top ten list in sleep’, Chest, 122 (4), 2002, 1457–60.CrossRefGoogle Scholar
- 63.S. Taheri et al., ‘The role of hypocretins (orexins) in sleep regulation and narcolepsy’, Annu. Rev. Neurosci., 25, 2002, 283–313.CrossRefGoogle Scholar
- 64.L. de Lecea, et al., ‘The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity’, Proc. Nat. Acad. Sci., 95, 1998, 322–7.CrossRefGoogle Scholar
- 65.T. Sakurai et al., ‘Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour’, Cell, 92, 1998, 573–85.CrossRefGoogle Scholar
- 66.P. Bourgin et al., ‘Hypocretin-1 modulates rapid eye movement sleep through activation of locus coeruleus neurons’, J. Neurosci., 20, 2000, 7760–7.Google Scholar
- 67.Ibid.Google Scholar