Pasteurella multocida toxin as a tool for studying Gq signal transduction
Pasteurella multocida toxin (PMT) stimulates and subsequently uncouples phospholipase C (PLC) signal transduction through its selective action on the Gαq subunit. This review summarizes what is currently known about the molecular action of PMT on Gq and the resulting cellular effects. Examples are presented illustrating the use of PMT as a powerful tool for dissecting the molecular mechanisms involving pertussis toxin (PT)-insensitive heterotrimeric G proteins.
KeywordsActin Stress Fiber Formation Atrophic Rhinitis Pasteurella Multocida Toxin 1AAR Activation P115 RhoGEF
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