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Pasteurella multocida toxin as a tool for studying Gq signal transduction

  • B. A. WilsonEmail author
  • M. Ho
Chapter
Part of the Reviews of Physiology, Biochemistry and Pharmacology book series (REVIEWS, volume 152)

Abstract

Pasteurella multocida toxin (PMT) stimulates and subsequently uncouples phospholipase C (PLC) signal transduction through its selective action on the Gαq subunit. This review summarizes what is currently known about the molecular action of PMT on Gq and the resulting cellular effects. Examples are presented illustrating the use of PMT as a powerful tool for dissecting the molecular mechanisms involving pertussis toxin (PT)-insensitive heterotrimeric G proteins.

Keywords

Actin Stress Fiber Formation Atrophic Rhinitis Pasteurella Multocida Toxin 1AAR Activation P115 RhoGEF 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag 2004

Authors and Affiliations

  1. 1.Department of MicrobiologyUniversity of Illinois at Urbana-ChampaignUrbanaUSA

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