The role of SHIP in cytokine-induced signaling

  • J. Kalesnikoff
  • L. M. Sly
  • M. R. Hughes
  • T. Büchse
  • M. J. Rauh
  • L.-P. Cao
  • V. Lam
  • A. Mui
  • M. Huber
  • G. KrystalEmail author
Part of the Reviews of Physiology, Biochemistry and Pharmacology book series (REVIEWS, volume 149)


The phosphatidylinositol (PI)-3 kinase (PI3K) pathway plays a central role in regulating many biological processes via the generation of the key second messenger PI-3,4,5-trisphosphate (PI-3,4,5-P3). This membrane-associated phospholipid, which is rapidly, albeit transiently, synthesized from PI-4,5-P2 by PI3K in response to a diverse array of extracellular stimuli, attracts pleckstrin homology (PH) domain-containing proteins to membranes to mediate its many effects. To ensure that the activation of this pathway is appropriately suppressed/terminated, the ubiquitously expressed tumor suppressor PTEN hydrolyzes PI-3,4,5-P3 back to PI-4,5-P2 while the 145-kDa hemopoietic-restricted SH2-containing inositol 5′-phosphatase, SHIP (also known as SHIP1), the 104-kDa stem cell-restricted SHIP (sSHIP) and the more widely expressed 150-kDa SHIP2 hydrolyze PI-3,4,5-P3 to PI-3,4-P2. In this review we will concentrate on the properties of the three SHIPs, with special emphasis being placed on the role that SHIP plays in cytokine-induced signaling.


Mast Cell Tyrosine Phosphorylation Erythroid Progenitor Steel Factor Inhibitory FcgRIIB 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



B cell receptor


Bone marrow derived mast cells



ES Cells

embryonic stem cells


Granulocyte macrophage colony stimulating factor






Macrophage colony stimulating factor


Pleckstrin homology


Phosphatidylinositol-3 kinase




Src homology 2 containing inositol 5′-phosphatase


Steel Factor


Stem cell SHIP


T cell receptor




Wild type


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© Springer-Verlag 2003

Authors and Affiliations

  • J. Kalesnikoff
    • 1
  • L. M. Sly
    • 1
  • M. R. Hughes
    • 1
  • T. Büchse
    • 1
  • M. J. Rauh
    • 1
  • L.-P. Cao
    • 1
  • V. Lam
    • 1
  • A. Mui
    • 2
  • M. Huber
    • 3
  • G. Krystal
    • 1
    Email author
  1. 1.The Terry Fox LaboratoryB.C. Cancer AgencyVancouverCanada
  2. 2.The Jack Bell Research CentreVancouver Hospital and Health Sciences CentreVancouverCanada
  3. 3.Department of Molecular Immunology, Biology IIIUniversity of Freiburg and Max-Planck-Institute for ImmunobiologyFreiburgGermany

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