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Granulocyte colony-stimulating factor and its receptor in normal hematophoietic cell development and myeloid disease

  • G. J. M. van de Geijn
  • L. H. J. Aarts
  • S. J. Erkeland
  • J. M. Prasher
  • L. P. Touw
Chapter
Part of the Reviews of Physiology, Biochemistry and Pharmacology book series (REVIEWS, volume 149)

Abstract

Hematopoiesis, the process of blood cell formation, is orchestrated by cytokines and growth factors that stimulate the expansion of different progenitor cell subsets and regulate their survival and differentiation into mature blood cells. Granulocyte colony-stimulating factor (G-CSF) is the major hematopoietic growth factor involved in the control of neutrophil development. G-CSF is now applied on a routine basis in the clinic for treatment of congenital and acquired neutropenias. G-CSF activates a receptor of the hematopoietin receptor superfamily, the G-CSF receptor (G-CSF-R), which subsequently triggers multiple signaling mechanisms. Here we review how these mechanisms contribute to the specific responses of hematopoietic cells to G-CSF and how perturbations in the function of the G-CSF-R are implicated in various types of myeloid disease.

Keywords

Acute Myeloid Leukemia Myeloid Progenitor Cell Severe Congenital Neutropenia Severe Chronic Neutropenia Cytokine Receptor Homology Domain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • G. J. M. van de Geijn
    • 1
  • L. H. J. Aarts
    • 1
  • S. J. Erkeland
    • 1
  • J. M. Prasher
    • 1
  • L. P. Touw
    • 1
  1. 1.Department of HematologyErasmus University Medical CenterRotterdamThe Netherlands

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