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Onconstatin M, a multifunctional cytokine

  • M. TanakaEmail author
  • A. Miyahima
Chapter
Part of the Reviews of Physiology, Biochemistry and Pharmacology book series (REVIEWS, volume 149)

Abstract

Oncostatin M (OSM) is a multifunctional cytokine that belongs to the Interleukin (IL)-6 subfamily. Among the family members, OSM is most closely related to leukemia inhibitory factor (LIF) and it in fact utilizes the LIF receptor in addition to its specific receptor in the human. While OSM was originally recognized by its unique activity to inhibit the proliferation of tumor cells, accumulating evidence now indicates that OSM exhibits many unique biological activities in inflammation, hematopoiesis, and development. Here, we review the profile of OSM activities, receptors, and signal transduction.

Keywords

Leukemia Inhibitory Factor A375 Melanoma Cell Fetal Hepatocyte Leukemia Inhibitory Factor Receptor Signal Transducer Gp130 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

G-CSF

Granulocyte-colony stimulating factor

GM-CSF

Granulocyte-macrophage colony stimulating factor

GAS

γ Interferon-activated site

Grb

Growth factor receptor-bound protein

Gab

Grb-2-associated binder

SHP

SH2 domain-containing protein tyrosine phosphatase

STAT

Signal transducer and activator of transcription

TEL

Translocated ets leukemia

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© Springer-Verlag 2003

Authors and Affiliations

  1. 1.Institue of Molelcular and Cellular BiosciencesUniversity of TokyoTokyoJapan
  2. 2.Kanagawa Academy of Science and TechnologyOsaka UniversityKawasakiJapan

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