Onconstatin M, a multifunctional cytokine

  • M. TanakaEmail author
  • A. Miyahima
Part of the Reviews of Physiology, Biochemistry and Pharmacology book series (REVIEWS, volume 149)


Oncostatin M (OSM) is a multifunctional cytokine that belongs to the Interleukin (IL)-6 subfamily. Among the family members, OSM is most closely related to leukemia inhibitory factor (LIF) and it in fact utilizes the LIF receptor in addition to its specific receptor in the human. While OSM was originally recognized by its unique activity to inhibit the proliferation of tumor cells, accumulating evidence now indicates that OSM exhibits many unique biological activities in inflammation, hematopoiesis, and development. Here, we review the profile of OSM activities, receptors, and signal transduction.


Leukemia Inhibitory Factor A375 Melanoma Cell Fetal Hepatocyte Leukemia Inhibitory Factor Receptor Signal Transducer Gp130 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Granulocyte-colony stimulating factor


Granulocyte-macrophage colony stimulating factor


γ Interferon-activated site


Growth factor receptor-bound protein


Grb-2-associated binder


SH2 domain-containing protein tyrosine phosphatase


Signal transducer and activator of transcription


Translocated ets leukemia


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© Springer-Verlag 2003

Authors and Affiliations

  1. 1.Institue of Molelcular and Cellular BiosciencesUniversity of TokyoTokyoJapan
  2. 2.Kanagawa Academy of Science and TechnologyOsaka UniversityKawasakiJapan

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