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Parallel Reactor Systems for Bioprocess Development

  • Dirk Weuster-BotzEmail author
Chapter
Part of the Advances in Biochemical Engineering book series (ABE, volume 92)

Abstract

Controlled parallel bioreactor systems allow fed-batch operation at early stages of process development. The characteristics of shaken bioreactors operated in parallel (shake flask, microtiter plate), sparged bioreactors (small-scale bubble column) and stirred bioreactors (stirred-tank, stirred column) are briefly summarized. Parallel fed-batch operation is achieved with an intermittent feeding and pH-control system for up to 16 bioreactors operated in parallel on a scale of 100 ml. Examples of the scale-up and scale-down of pH-controlled microbial fed-batch processes demonstrate that controlled parallel reactor systems can result in more effective bioprocess development. Future developments are also outlined, including units of 48 parallel stirred-tank reactors with individual pH- and pO2-controls and automation as well as liquid handling system, operated on a scale of ml.

Bioprocess development Parallel bioreactors Intermittent feeding Parallel control Scale-up/scale-down 

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Authors and Affiliations

  1. 1.Lehrstuhl für BioverfahrenstechnikTechnische Universität MünchenGarchingGermany

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