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Regulating membrane curvature

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Book cover Regulatory Mechanisms of Intracellular Membrane Transport

Part of the book series: Topics in Current Genetics ((TCG,volume 10))

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Abstract

Membranes of living cells are subject to a variety of shape changes. Membrane deformation is essential for cell division, locomotion, organelle biogenesis, and creation of the high-curvature vesicles and tubules that mediate cargo transport along the endo- and exocytic pathways. Yet membrane bilayers are stabilized against deformations by a powerful hydrophobic effect. Moreover, the various membrane-bound organelles of a cell are composed of different mixtures of lipids, with each lipid species contributing differently to membrane elasticity and shape. So how do cells adopt the desired radii of curvature in their bilayers? A long-standing concept is that membrane curvature can be induced by assembly of a protein coat onto one side of the bilayer. Recent studies indicate that lipids too can serve as the molecular workers in accomplishing the structural changes needed to deform cellular membranes.

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  1. Department of Membrane Enzymology, Faculty of Chemistry, Padualaan 8, 3584 CH Utrecht, The Netherlands

    Joost C.M. Holthuis

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Sirkka Keränen Jussi Jäntti

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Holthuis, J.C. Regulating membrane curvature. In: Keränen, S., Jäntti, J. (eds) Regulatory Mechanisms of Intracellular Membrane Transport. Topics in Current Genetics, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/b98566

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  • DOI: https://doi.org/10.1007/b98566

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