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Complexation of DNA with biocompatible diblock copolymers

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Surface and Colloid Science

Part of the book series: Progress in Colloid and Polymer Science ((PROGCOLLOID,volume 128))

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Abstract

A novel diblock copolymer, consisting of a biocompatible phosphorylcholine block (MPC) and a pH sensitive dimethylamino ethyl block (DMA), denoted as MPC30DMA60, shows interesting properties of surface adsorption and solution aggregation. These features have been exploited to condense DNA into nanoaggregates in bulk solution and to immobilise DNA onto a substrate surface. These molecular manipulations may find their applications in controlled release and bionanotechnology.

Acknowledgements: We thank Biocompatibles UK Ltd., for financial support to Q.S.M. We also thank EPSRC for the support of the neutron experiments.

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Authors and Affiliations

  1. Physics Department, University of Manchester Institute of Science and Technology, 88, Manchester, M60 1QD, UK

    Q. S. Mu & J. R. Lu

  2. School of Chemistry, Physics and Environmental Science, University of Sussex, Falmer, Brighton, BN1 9QJ, UK

    Y. H. Ma & S. P. Armes

  3. Biocompatibles Ltd., Farnham Business Park, Weydon Lane, Farnham, GU9 8QL, UK

    A. L. Lewis

Authors
  1. Q. S. Mu
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  2. Y. H. Ma
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  3. A. L. Lewis
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  4. S. P. Armes
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  5. J. R. Lu
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Corresponding author

Correspondence to Q. S. Mu .

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© 2004 Springer-Verlag

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Mu, Q.S., Ma, Y.H., Lewis, A.L., Armes, S.P., Lu, J.R. (2004). Complexation of DNA with biocompatible diblock copolymers. In: Surface and Colloid Science. Progress in Colloid and Polymer Science, vol 128. Springer, Berlin, Heidelberg. https://doi.org/10.1007/b97072

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  • DOI: https://doi.org/10.1007/b97072

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-21247-8

  • Online ISBN: 978-3-540-39980-3

  • eBook Packages: Springer Book Archive

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