Skip to main content
SpringerLink
Log in

Adsorption and desorption of interferon onto colloidal hydrophobic surfaces

  • Conference paper
  • First Online:
Trends in Colloid and Interface Science XVII

Part of the book series: Progress in Colloid and Polymer Science ((PROGCOLLOID,volume 126))

  • 66 Accesses

Abstract

Medusa technology for protein delivery is based on the self assembly of amphiphilic polyaminoacids and proteins. The well controlled synthesis of random poly(1-leucin-b-1-glutamate) leads to nanoparticles which adsorb interferon alpha 2b in water. Preclinical results in dogs demonstrate a sustained release of the non denaturated protein over more than 5 days.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Author information

Authors and Affiliations

  1. Flamel Technologies, 69693, Vénissieux, France

    J. P. Lecomte, O. Soula, R. Meyrueix, A. Constancis, S. Angot & G. Soula

Authors
  1. J. P. Lecomte
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. O. Soula
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. Meyrueix
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. Constancis
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S. Angot
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. G. Soula
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Lecomte, J.P., Soula, O., Meyrueix, R., Constancis, A., Angot, S., Soula, G. (2004). Adsorption and desorption of interferon onto colloidal hydrophobic surfaces. In: Trends in Colloid and Interface Science XVII. Progress in Colloid and Polymer Science, vol 126. Springer, Berlin, Heidelberg. https://doi.org/10.1007/b94011

Download citation

  • DOI: https://doi.org/10.1007/b94011

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-20073-4

  • Online ISBN: 978-3-540-39761-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation