Abstract
The aim of this work was the design of a pH-sensitive system consisting of an amphiphilic polymer and a β-cyclodextrin coepichlorhydrin water-soluble polymer (pβCD/EP). Different modified dextrans were synthesized from reaction of dextran (M w =40,000) with phthalic anhydride, 2-phenylglutaric anhydride and 1,2-cyclohexane dicarboxylic anhydride with grafting ratio around 2%. The viscometric study of modified dextrans with pendant cyclohexane carboxylic acid groups mixed with pβCD/EP was performed at pH 1 and 7 and showed a small increase of reduced viscosity compared to mixtures of dextran and pβCD/EP. The phase diagram shows association phase-separation at low pH, whereas monophasic mixtures were obtained at pH higher than the pK a . Furthermore this phase-separation is reversible according to the pH. The use of 8-anilinonaphtalene-1-sulfonic acid, as a fluorescent probe, allowed us to determine the inclusion constants of the modified dextrans. Complexation constants higher by 1 order of magnitude for the most hydrophobically modified dextrans were obtained at pH 2.5 compared to pH 7.
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© 2004 Springer-Verlag Berlin Heidelberg
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Gosselet, N.M., Layre, A.M., Wintgens, V., Amiel, C. (2004). Physicochemical study of modified dextrans with a β-cyclodextrin polymer. In: Trends in Colloid and Interface Science XVII. Progress in Colloid and Polymer Science, vol 126. Springer, Berlin, Heidelberg. https://doi.org/10.1007/b93966
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DOI: https://doi.org/10.1007/b93966
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Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-20073-4
Online ISBN: 978-3-540-39761-8
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