A modular systems biology analysis of cell cycle entrance into S-phase

  • Lilia AlberghinaEmail author
  • Riccardo L. Rossi
  • Danilo Porro
  • Marco Vanoni
Part of the Topics in Current Genetics book series (TCG, volume 13)


A modular systems biology approach to the study of the cell cycle of the budding yeast Saccharomyces cerevisiae is presented. Literature on the structure of yeast population and its relevance to the study of yeast cell cycle is reviewed. A model for the control of yeast cell cycle, with emphasis on a threshold mechanism controlling entrance into S-phase is presented. The simple model has been used as a framework to derive a molecular blow-up of the major upstream events controlling the G1 to S transition that involves two sequential thresholds cooperating in carbon source modulation of the critical cell size required to enter S-phase, a hallmark response of the cell cycle to changing growth conditions. The model is discussed as an aid to filter and give structure to post-genomic data. The iterative application of this approach allows to obtain more refined models capturing the major regulatory features and the molecular details of the circuits connecting cell growth to cell cycle.


Yeast Population Yeast Cell Cycle Cell Cycle Entrance Cell Protein Content Average Protein Content 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Authors and Affiliations

  • Lilia Alberghina
    • 1
    Email author
  • Riccardo L. Rossi
    • 1
  • Danilo Porro
    • 1
  • Marco Vanoni
    • 1
  1. 1.University of Milano - Bicocca, Department of Biotechnology and Biosciences, Piazza della Scienza 2, 20126 MilanoItaly

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