Metabolic Control Analysis
Metabolic Control Analysis (MCA) is a theoretical framework for investigating and understanding control and regulation of metabolism. In particular, it relates the properties of metabolic systems to the kinetic characteristics of the component enzymes. However, not all of the properties of enzymes strongly influence the be-haviour of metabolic systems, some of which is generic and is reviewed here. It is argued that MCA is an important component of systems biology that still has much to offer in the development of predictive and integrative biology and the linking of genome to phenotype.
KeywordsSystem Biology Metabolic Network Metabolite Concentration Metabolic Flux Metabolic System
Unable to display preview. Download preview PDF.
- 9. Fell DA (1997) Understanding the Control of Metabolism. Portland Press, LondonGoogle Scholar
- 10. Fell DA (2000) Signal transduction and the control of expression of enzyme activity. Ad-van Enzym Regul 40:35-46Google Scholar
- 14. Groen AK, van der Meer R, Westerhoff HV, Wanders RJA, Akerboom TPM, Tager JM (1982) Control of metabolic fluxes. Metabolic Compartmentation, ed. Sies H, Aca-demic Press, London, pp. 9-37Google Scholar
- 23. Kacser H, Burns JA (1973) The control of flux. Symp Soc Exp Biol 27:65-104. Reprinted in Biochem Soc Trans (1995) 23:341-366Google Scholar
- 29. Korzeniewski B, Harper ME, Brand MD (1995) Proportional activation coefficients during stimulation of oxidative phosphorylation by lactate and pyruvate or vasopressin. Bio-chim Biophys Acta 1229:315-322Google Scholar
- 31. Newsholme EA, Start C (1973) Regulation in Metabolism. Wiley and Sons, LondonGoogle Scholar
- 34. Raamsdonk LM, Teusink B, Broadhurst D, Zhang NS, Hayes A, Walsh MC, Berden JA, Brindle KM, Kell DB, Rowland JJ, Westerhoff HV, Dam KV, Oliver SG (2001) A functional genomics strategy that uses metabolome data to reveal the phenotype of si-lent mutations. Nat Biotechnol 19:45-50CrossRefPubMedGoogle Scholar
- 36. Savageau MA (1976) Biochemical Systems Analysis: a Study of Function and Design in Molecular Biology. Addison-Wesley, Reading, MassGoogle Scholar
- 45. Weibel ER (2000) Symmorphosis. On Form and Function in Shaping Life. Harvard Uni-versity Press, CambridgeGoogle Scholar