Mechanistic and modular approaches to modeling and inference of cellular regulatory networks

  • Boris N. KholodenkoEmail author
  • Frank J. Bruggeman
  • Herbert M. Sauro
Part of the Topics in Current Genetics book series (TCG, volume 13)


In this chapter we wish to present a vision of systems biology as a discipline that generates new insight and knowledge with quantitative and predictive explanatory power at the system level. We will review work that combines quantitative measurements and mathematical and computational modeling of signaling networks to link molecular mechanisms to physiological responses. An emerging synergistic modeling approach is presented that uses novel approaches to network inference, molecular dynamic simulations, chemical kinetics and reaction-diffusion equations, and functional modularization in biochemical networks.


Cellular Network Epidermal Growth Factor Receptor Signaling Network Inference Receptor Tyrosine Kinase Signaling Connection Coefficient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Authors and Affiliations

  • Boris N. Kholodenko
    • 1
    Email author
  • Frank J. Bruggeman
    • 2
  • Herbert M. Sauro
    • 3
  1. 1.Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust St., Philadelphia, PA 19107USA
  2. 2.Molecular Cell Physiology & Integrative Bioinformatics, Biocentrum & Faculty of Earth and Life Sciences, De Boelelaan 1085, 1081 HV, Vrije Universiteit, AmsterdamThe Netherlands
  3. 3.Keck Graduate Institute, 535 Watson Drive, Claremont, CA 91106, USA, and Control and Dynamical Systems, California Institute of Technology, Pasadena, CA 91125USA

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