Integration of metabolic and signaling networks

  • Dirk MüllerEmail author
  • Luciano Aguilera-Vázquez
  • Matthias Reuss
  • Klaus Mauch
Part of the Topics in Current Genetics book series (TCG, volume 13)


This contribution addresses the construction of mathematical models that provide a combined description of metabolic and regulatory processes within cells. In the first part of the article, strategies for reconstruction of metabolic and signaling networks are outlined followed by a discussion of their characteristic properties. The second part focuses on the development of integrated models of metabolism and signal transduction. The case of yeast cyclic AMP (cAMP) signaling and its interaction with energy metabolism and elements of the cell cycle machinery is used to exemplify this approach.


Metabolic Network Signaling Network Functional Module Yeast Cell Cycle Anaphase Promote Complex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Authors and Affiliations

  • Dirk Müller
    • 1
    Email author
  • Luciano Aguilera-Vázquez
    • 1
  • Matthias Reuss
    • 1
  • Klaus Mauch
    • 1
  1. 1.Institute for Biochemical Engineering, Allmandring 31, 70569 StuttgartGermany

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