Non-Salen Metal-Catalyzed Asymmetric Dihydroxylation and Asymmetric Aminohydroxylation of Alkenes. Practical Applications and Recent Advances
Over the past two decades the asymmetric dihydroxylation (AD) and asymmetric aminohydroxylation (AA) of alkenes has attracted a great deal of attention. Many literature examples have demonstrated that good to excellent ees and yields can be obtained with a diverse range of alkenes. The ability to perform reactions on small to moderate scale has led to increased utilization in larger scale applications. This review highlights recent advances in the AD and AA pertaining to practical, large-scale and industrial applications.
KeywordsAsymmetric dihydroxylation Asymmetric aminohydroxylation Cinchona alkaloids Process development Scale up
List of Abbreviations
Chemzyme membrane reactor
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