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Fine-Tuning of RNA Functions by Modification and Editing pp 309–340Cite as

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  2. Fine-Tuning of RNA Functions by Modification and Editing
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Translational Recoding and RNA Modifications

Translational Recoding and RNA Modifications

  • Olivier Namy1,
  • François Lecointe2,
  • Henri Grosjean2 &
  • …
  • Jean-Pierre Rousset1 
  • Chapter
  • First Online: 01 January 2005

  • 1518 Accesses

  • 8 Citations

Part of the Topics in Current Genetics book series (TCG,volume 12)

Abstract

During protein synthesis, codons in mRNA are translated sequentially in frame on the ribosome following strict decoding rules. This process is usually very accurate. However, in some cases, recoding events occur at selected codons, leading to a high frequency of frameshifting or stop codon readthrough. The factors influencing these noncanonical decoding events are very diverse; among them are the codon usage and context, the presence of a stable mRNA secondary structure downstream of the decoding sites and the type and relative abundance of normally modified tRNA. Here, we discuss the role of certain modified nucleotides of tRNAs in a few cases of frameshifting and readthrough that occur in Bacteria and Eukarya. While in some cases the effect of a given modified nucleotide in a tRNA is to increase accuracy of the recoding process, in a few other cases the reverse has been observed. This review illustrates the power of using well characterized recoding systems, coupled with specific defects of RNA modification enzymes to assay for translational fidelity under in vivo conditions.

Keywords

  • Modify Nucleotide
  • Shine Dalgarno
  • Ribosomal Frameshifting
  • tRNA Modification
  • Translational Readthrough

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Authors and Affiliations

  1. Institut de Génétique et Microbiologie, Université Paris-Sud, F-91405 Orsay cedex, France

    Olivier Namy & Jean-Pierre Rousset

  2. Laboratoire d’Enzymologie et Biochimie Structurales, CNRS, F-91198 Gif-sur-Yvette, France

    François Lecointe & Henri Grosjean

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Henri Grosjean

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Namy, O., Lecointe, F., Grosjean, H., Rousset, JP. Translational Recoding and RNA Modifications. In: Grosjean, H. (eds) Fine-Tuning of RNA Functions by Modification and Editing. Topics in Current Genetics, vol 12. Springer, Berlin, Heidelberg. https://doi.org/10.1007/b106847

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